Research Post Doctoral Fellow\: Computational Biology and Bioinformatics with Cancer Emphasis

Job Description:
The laboratory headed by Ajay Goel, PhD focuses on understanding the interplay between genetic and epigenetic alterations in colorectal, pancreatic, gastric and esophageal cancers. We are a multidisciplinary research group, undertaking a number of collaborative projects involving large international consortia. The projects will involve any/all of the following research focuses.

• Exploration of the role of aberrant DNA methylation, histone modifications and non-coding RNA's (miRNA, lncRNAs, snoRNAs, piRNAs etc.) in gastrointestinal cancers.
• Establishment of innovative methodologies for the development of epigenetic and non-coding RNA's-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
• A better understanding of the translational and clinical role ofgenetic and epigenetic signatures in gastrointestinal cancers.
• Understanding the genetic basis of early-onset and familial colorectal cancers.
• Chemoprevention of gastrointestinal cancers using dietary nutraceuticals, non-steroidal anti-inflammatory drugs (NSAIDs), and other drugs.
• Molecular mechanisms of cancer chemotherapy, stem cells, chemo-resistance and chemo-sensitization.
• Gut microbiome, and its influence on gastrointestinal cancers.

The position is largely computational but involves substantial collaboration with wet-lab researchers providing data and is focused on fundamental biology. This interdisciplinary position offers opportunities to address important questions in computational biology and cancer genomics with first access to large novel data sets from various genomic/epigenomic platforms. We have a strong preference for bioinformaticians/computational biologists with a deep appreciation of biological phenomena or, alternatively, experimentalists with a solid background in bioinformatics/computational biology analysis of transcriptomic and genomic data with regard to detection of differentially expressed genes, noncoding RNA's, DNA methylation and differential processing profiles.

This individual will also have the opportunity to develop original statistical and machine learning methodologies and analytical and computational tools to extract knowledge from complex and big data.

The Ideal Candidate Will Possess:

• An excellent track record of analyzing nextgeneration sequencing data in cancer, particularly whole genome, RNASeq and methylation sequencing analysis including: Differential expression analysis, SNV calling, indel calling, rearrangement/translocation calling, CNV identification and analysis.
• A good knowledge and understanding of cancer biology
• Passion for science and reproducible scientific work
• Proficient in spoken and written English
• Being comfortable in interacting with colleagues in an interdisciplinary setting

Doctorate Degree required in Bioinformatics, Computer Science, Data Science, Mathematics, Statistics, Physics or Equivalent

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Requeriments :

• Doctorate Degree

Skills :

• Bioinformatics
• Biology
• Cancer biology
• Cancer Genomics
• Computational Biology
• Machine Learning
• Next Generation Sequencing
• RNA-seq
• Statistics
• Transcriptomics

Areas :

• Bioinformatics

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Additional Info:
Location/Facility Baylor Research Institute, Dallas TX

For more information on the facility, please click our Locations link.

Specialty/Department/Practice Research

Shift/Schedule Full Time, M-F

Benefits Our competitive benefits package includes*:

Immediate eligibility for health and welfare benefits

401(k) savings plan with dollar-for-dollar match up to 5%

Tuition Reimbursement

PTO accrual beginning Day 1

Note: Benefits may vary based upon position type and/or level.

Baylor Scott & White Health (BSWH) is the largest not-for-profit health care system in Texas and one of the largest in the United States. With a commitment to and a track record of innovation, collaboration, integrity and compassion for the patient, BSWH stands to be one of the nation's exemplary health care organizations. Our mission is to serve all people by providing personalized health and wellness through exemplary care, education and research as a Christian ministry of healing. Joining our team is not just accepting a job, it's accepting a calling!

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