Job ID: 359025131
Job date: 2017-06-03
End Date:
Company : MedImmune, LLC Country : Role : Research Scientist
Job date: 2017-06-03
End Date:
Company : MedImmune, LLC Country : Role : Research Scientist
Job Description:
The Research Bioinformatics Scientist is primarily responsible for advancing scientific knowledge through the use and development of Bioinformatics tools and approaches, and applying that knowledge to drug development programs and innovative Research Science. This scientifically passionate individual will apply their experience in the analysis, collection, mining and integration of multiple -omics data sets including proteomics, metabolomics, genomics, transcriptomics, flow cytometry, and microRNA using bioinformatics and system biology approaches to advance our understanding of biological pathways, networks, and genetic interactions. The candidate will have a strong background in analyzing quantitative MS-based proteomics toward target and biomarker discovery and validation. Direct experience developing analytical techniques and data integration methodologies in support of biomedical research and relevant experience in one or more disease areas (i.e. cardiometabolic, oncology, respiratory, inflammation, autoimmune, or infectious diseases) are required. Experience in drug and target discovery, biostatistics, information sciences and patient-disease stratification projects required. The successful candidate will support drug development projects and programs and work closely with both therapeutic area scientists and core informatics scientists to establish integrative informatics technologies and services that accelerate MedImmune’s biologics drug development initiatives. This role will have the opportunity to engage with strategic investments in the areas of target identification, integrative informatics, big data, -omics technologies, scientific portfolio knowledge management, predictive science, precision healthcare, and the use of patient information in biopharmaceutical R&D. The successful candidate, working with members of the bioinformatics team, will be responsible the delivery of data processes, tools, and methods to manage drug project information and knowledge. This role resides within R&D, and will work collaboratively within Research Bioinformatics and across therapeutic area teams to design, develop, and implement tools, systems, and methods to facilitate the mining of large complex multi-platform datasets and advance our understanding of disease. Major Duties And Responsibilities: -Perform expert informatics research, including establishment of scientific hypotheses that can be approached using computational methods and tools. -Be an active embedded participant in research functions, executing bioinformatics projects and analyses to support biopharmaceutical projects both as directed and as opportunities present themselves. -Support biopharmaceutical data mining activities through the design and delivery of novel tools and techniques. -Provide technical support on the design and implementation of large-scale databases of proteomics, metabolomics, genomics and other datasets in conjunction with R&D Information Systems and external partners. -Work with external and internal collaborators to examine, transfer, and index data towards development of automated data processing pipelines. -Provide training and advice to project scientists on optimal use of key data, analysis platforms and the appropriate use of biostatistics. -Build and manage effective relationships to ensure utilization of information resources and services. Assist with the evaluation and implementation of new and existing data and analytical systems. -Provide subject matter expertise and share knowledge on computational biology tools, experimental design, data analysis methodologies, data interpretation, and novel approaches to support target discovery and validation. -Work with biopharmaceutical researchers to communicate requirements for custom informatics resources. -Actively contribute to the establishment of the informatics body of knowledge and technology “toolbox” that is broadly applied to R&D scientific questions. Assist and support the core informatics team with integration of R&D informatics systems to maximize speed to the clinic. -Promote a culture of knowledge sharing across domains to proactively support sharing of best practices among informatics and science teams. -Represent Research Bioinformatics department at scientific conferences and talks, and prepare manuscripts for publication in peer reviewed journals to advance scientific knowledge. -Work effectively with external experts or collaborative groups promoting optimal use of informatics, scientific analysis, data utilization, information and knowledge. -Actively identify and progress opportunities to collaborate externally in support of departmental scientific and technical goals
Additional Info:
If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us. MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As a Bioinformatics Scientist II/Sr. Scientist in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives. We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules. MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent. Next Steps – Apply today! To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.[Click Here to Access the Original Job Post]
The Research Bioinformatics Scientist is primarily responsible for advancing scientific knowledge through the use and development of Bioinformatics tools and approaches, and applying that knowledge to drug development programs and innovative Research Science. This scientifically passionate individual will apply their experience in the analysis, collection, mining and integration of multiple -omics data sets including proteomics, metabolomics, genomics, transcriptomics, flow cytometry, and microRNA using bioinformatics and system biology approaches to advance our understanding of biological pathways, networks, and genetic interactions. The candidate will have a strong background in analyzing quantitative MS-based proteomics toward target and biomarker discovery and validation. Direct experience developing analytical techniques and data integration methodologies in support of biomedical research and relevant experience in one or more disease areas (i.e. cardiometabolic, oncology, respiratory, inflammation, autoimmune, or infectious diseases) are required. Experience in drug and target discovery, biostatistics, information sciences and patient-disease stratification projects required. The successful candidate will support drug development projects and programs and work closely with both therapeutic area scientists and core informatics scientists to establish integrative informatics technologies and services that accelerate MedImmune’s biologics drug development initiatives. This role will have the opportunity to engage with strategic investments in the areas of target identification, integrative informatics, big data, -omics technologies, scientific portfolio knowledge management, predictive science, precision healthcare, and the use of patient information in biopharmaceutical R&D. The successful candidate, working with members of the bioinformatics team, will be responsible the delivery of data processes, tools, and methods to manage drug project information and knowledge. This role resides within R&D, and will work collaboratively within Research Bioinformatics and across therapeutic area teams to design, develop, and implement tools, systems, and methods to facilitate the mining of large complex multi-platform datasets and advance our understanding of disease. Major Duties And Responsibilities: -Perform expert informatics research, including establishment of scientific hypotheses that can be approached using computational methods and tools. -Be an active embedded participant in research functions, executing bioinformatics projects and analyses to support biopharmaceutical projects both as directed and as opportunities present themselves. -Support biopharmaceutical data mining activities through the design and delivery of novel tools and techniques. -Provide technical support on the design and implementation of large-scale databases of proteomics, metabolomics, genomics and other datasets in conjunction with R&D Information Systems and external partners. -Work with external and internal collaborators to examine, transfer, and index data towards development of automated data processing pipelines. -Provide training and advice to project scientists on optimal use of key data, analysis platforms and the appropriate use of biostatistics. -Build and manage effective relationships to ensure utilization of information resources and services. Assist with the evaluation and implementation of new and existing data and analytical systems. -Provide subject matter expertise and share knowledge on computational biology tools, experimental design, data analysis methodologies, data interpretation, and novel approaches to support target discovery and validation. -Work with biopharmaceutical researchers to communicate requirements for custom informatics resources. -Actively contribute to the establishment of the informatics body of knowledge and technology “toolbox” that is broadly applied to R&D scientific questions. Assist and support the core informatics team with integration of R&D informatics systems to maximize speed to the clinic. -Promote a culture of knowledge sharing across domains to proactively support sharing of best practices among informatics and science teams. -Represent Research Bioinformatics department at scientific conferences and talks, and prepare manuscripts for publication in peer reviewed journals to advance scientific knowledge. -Work effectively with external experts or collaborative groups promoting optimal use of informatics, scientific analysis, data utilization, information and knowledge. -Actively identify and progress opportunities to collaborate externally in support of departmental scientific and technical goals
Essential Requirements
Education: Advanced degree (M.S./Ph.D. or equivalent experience preferred) in Bioinformatics, Computational Biology, Systems Biology, Immunology or related field. Essential Skills & Experience: -Scientist II – Masters with 8-10 years of experience or PhD with 5-8 years’ experience -Senior Scientist – Masters with 10+ years’ experience or PhD with 8-10 years’ experience -Experience within a pharmaceutical/biotech company, pharmaceutical information provider, or other relevant biomedical research environment required. Demonstrated knowledge and understanding of the Life Sciences Healthcare industry and how it operates desirable. -Demonstrated understanding in the methods of protein identification and quantitation by mass spectrometry, and proficiency in different statistical models, MS bioinformatics software such as MaxQuant, MASCOT, SEQUEST, MSGF and others for peptide/protein identification and quantitation, and cellular localization, function, and pathway analysis tools such as IPA, Pathway Studio, cytoscape, GSEA, GO, TMHMM, and SignalP. -Solid knowledge of informatics tools and visualization/data mining packages (e.g. R/Shiny, Spotfire, ArrayStudio, genome visualization packages/browsers) and aptitude for adapting to complex new analysis packages and using them to their full potential. -Proficiency in common programming/scripting languages (e.g. R, Python, SQL, JAVA, Perl) and their application in biomedical research. -Proven record of working with biomedical researchers to develop and apply informatics solutions, skills, and tools. -First-hand experience in the analysis and interpretation of large, complex datasets. Familiarity with multiple R&D data types, especially as they relate to therapeutic area research. -Development and delivery of formal and informal training and supporting materials to non-experts. -Demonstrated successful experience working on complex, cross-functional project teams. -Proven capacity to communicate effectively with technical and scientific colleagues alike, in formal presentations and small group meetings. -Excellent written and oral communication skills. Desirable: -Demonstrated contributions in target discovery, indication discovery, and patient-disease stratification initiatives are highly desirable. -Proven track record of publishing relevant bioinformatics or systems biology results in peer-reviewed journals.-Direct experience in the development and implementation of large-scale biological databases and related activities; along with developing interactive web-based interfaces.
-Proficiency in Biostatistics. -Experience developing rich visualizations for complex scientific data sets. -Familiar with machine learning, NoSQL, knowledge capture and other innovations in predictive analytics and data-driven discovery. -Understanding of the regulatory requirements surrounding the handling and analysis of patient related information (GCDMP). -Prior experience working in a therapeutic drug development area or antibody research setting. -Demonstrated scientific knowledge of cell biology, molecular biology, or immunology, especially as it relates to biomedical research and development (targeted therapies, immunotherapies and stem cell therapies). -Direct laboratory experience and working with biologists to design and analyze experiments is advantageous.Requeriments :
Skills :
- Biostatistics
- Cell Biology
- Data Mining
- immunology
- Machine Learning
- molecular biology
- NoSQL
- Programing in Python
- Programing Skills
- Programming in PERL
- Programming in R
- SQL
Areas :
Additional Info:
If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us. MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As a Bioinformatics Scientist II/Sr. Scientist in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives. We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules. MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent. Next Steps – Apply today! To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.[Click Here to Access the Original Job Post]