Job date: 2016-08-18
End Date:
Company : Lantern Pharma Country : Role : Research Scientist
Scientist / Director – Precision cancer medicine and genetic signature development We are currently recruiting for a Sr.Scientist/Director to contribute to Lantern’s personalized medicine effort in oncology. The individual will perform both a critical strategic role, as well as hands-on role, in overseeing the scientific direction of programs involving precision medicine for biomarker development. The qualified individual will be a recognized expert in field of precision medicine, cancer biology, statistical genetics, human genetics, computational biology, biomarker identification, bioinformatics, drug development (with an emphasis on human genetics of complex traits) and have a strong understanding of functional interrogation of genetic findings, systems biology, and drug development. In addition to providing strategic and operational leadership, the incumbent will lead a cross functional team of engineers, scientists, clinicians, business analysts to identify, validate genetic signatures for Lantern’s drugs in the pipeline. Develop and implement biomarker and patient selection strategies for one or more early-stage clinical programs, collaborating closely with Clinical, Research, and Project Team leads. Design and coordinate execution of studies to validate fit-for-purpose biomarker assays, working with internal resources and through CROs. Contribute to biomarker sections of clinical trial protocols and regulatory documents, including informed consent, research specimen manuals, and validation reports. He/she will be expected to operate in a highly collaborative environment, partnering with peers, partners, and consultants on site (all therapeutic areas, pharmacology, chemistry, and experimental medicine) and at other locations in Massachusetts, Maryland and Europe. This position will also require extensive interactions with external partners, including leaders in academia as well as others.
Responsibilities - Participating as part of leadership team in developing, and driving, the strategy to identify and prioritize programs entering the early pipeline across all therapeutic areas. - Managing a budget responsible for the application of human genetics to drive target identification and validation. - Developing new external collaborations with academia and industry partners to leverage tools to exploit human genetics in order to discover new drug targets.- Working on grant submissions and proposals, Identifying new programs and opportunities for Lantern-Deep understanding of cancer biology-Understanding of clinical operations with the ability to implement well-designed experiments within a clinical trial environment.-Deep understanding of cancer biology, clinical oncology, genomic profiling, drug development-An understanding of translational approaches as applied to clinical trial design and regulatory processes, proof-of-concept studies, and the implementation of biomarkers and diagnostics- Integrate diverse ‘omics / biological datasets with human genetic data to identify novel pathways for drug development across all therapeutic areas. - Analyze and integrate large-scale genetic data sets, including next-generation sequencing (WGS, WES, RNA-Seq) and GWAS/RVAS data - Working with other data analysts and experimentalists to identify genes and variants associated with human phenotypes in families with rare Mendelian traits, as well as individuals from the general population, or distinct population cohorts; - Integrating genetic and clinical data with other ‘omics data sets to identify causal alleles, genes and pathways relevant to cancer - Use of interrogation tools to evaluate potential genetic targets for drug discovery - Identify dose-response-relationships between genetic perturbation of putative novel drug targets, and conducting comparative analysis of genetics with pharmacological perturbation; - Written and verbal communication of study results to project team and the scientific community, including proposals for further experiments and publications in leading journals; - In collaboration with strategic operations, manage a portfolio of projects to review and prioritize new and on-going projects
Requirements - PhD, or MD/PhD with 5+ years of experience (or equivalent) in the research and development of therapeutics or similar academic experience, leading biomarker assay development, validation & execution in clinical trials and the development of companion diagnostics experience - Demonstrated expertise in human statistical genetics, genomics, genetic epidemiology, or bioinformatics (peer reviewed publication, history of achievement, patents, etc.) with an appreciation of the role of human genetics for target identification and validation. - Demonstrable leadership skills. Proven ability to create and work within high performance teams and/or matrix organization, strong influencing skills. - Demonstrated ability to conduct research individually and collaboratively and prioritize work against departmental and company goals. - Excellent oral and written communication skills, ability to establish and maintain productive cross-site and high caliber external collaborations. - Proficiency to critically evaluate scientific and therapeutic proposals and adopt novel technologies to facilitate groundbreaking research.
Job Type: Full-time
Job Location:
New York, NYRequired education:
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