Job ID:
Job date: 2018-04-03
End Date:
Company : BioMarin Pharmaceutical Inc Country : Role : Research Scientist
Job date: 2018-04-03
End Date:
Company : BioMarin Pharmaceutical Inc Country : Role : Research Scientist
Job Description:
We’re seeking a Scientist / Senior Scientist of Computational Biology - BioInfomatics to join the growing drug discovery research group at BioMarin Pharmaceutical. The candidate will hellp manage the discovery activities to transform human genetics and genomics discoveries to therapeutic hypotheses, and effectively communicate results to impact multiple stages of our drug discovery and development pipeline. The successful candidate will have the opportunity to work in a fast-paced and highly collaborative environment and will be responsible for developing and employing rigorous statistical, computational, and bioinformatics approaches and to engage scientists and project teams to leverage genomics data in achieving project objectives. RESPONSIBILITIES:
Additional Info:
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind. BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.[Click Here to Access the Original Job Post]
We’re seeking a Scientist / Senior Scientist of Computational Biology - BioInfomatics to join the growing drug discovery research group at BioMarin Pharmaceutical. The candidate will hellp manage the discovery activities to transform human genetics and genomics discoveries to therapeutic hypotheses, and effectively communicate results to impact multiple stages of our drug discovery and development pipeline. The successful candidate will have the opportunity to work in a fast-paced and highly collaborative environment and will be responsible for developing and employing rigorous statistical, computational, and bioinformatics approaches and to engage scientists and project teams to leverage genomics data in achieving project objectives. RESPONSIBILITIES:
- Apply and develop robust statistical and computational approaches to analyze and integrate multi-omics data to drive disease/target/biomarker identification, mechanistic investigation, causal inference, and hypothesis generation/testing.
- Work closely with project teams and functional areas to identify and provide computational solutions to address key biological questions, including identifying datasets, formulating hypothesis, developing and implementing analytical solutions.
- Evaluate and develop bioinformatics methods to integrate, summarize and report genetic, genomic, and other omics data, examples include RNA-seq, scRNA-seq, WES/WGS, CHiP-seq, Hi-C and many other high-throughput and emerging genomics, epigenomics, proteomics, and metabolomics data.
- Solid foundation in computation and system biology
- Demonstrated ability to work in cross-functional teams and being a highly collaborative and active team contributor
- Hands-on experience to manage, analyze and interpret large genomics and functional genomics studies (e.g. GTEx, ENCODE, BLUEPRINT, Brain atlas, FANTOM)
- Knowledge and experience of statistical inference and machine learning analysis and software (e.g. differential expression, co-regulated gene networks, cell type stratification, causal inference, functional motif prediction)
- Statistical programming and scripting skills (R and Python/Perl/Shell/etc.), and experience with high performance computing
- Strong scientific curiosity and initiative, knowledge of experimental design
- Excellent problem-solving, teamwork, organization and communication skills
- Working experience of integrating GWAS analysis with molecular profiling data will be a plus (e.g. eQTL, epiQTL)
Requeriments :
Skills :
- Computational Biology
- genomic
- HPC
- Machine Learning
- Programing in Python
- Programing Skills
- Programming in PERL
- Programming in R
- RNA-seq
- Shell scripting
- Statistics
- Systems Biology
Areas :
Additional Info:
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind. BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.[Click Here to Access the Original Job Post]