Job date: 2016-05-08
End Date:
Company : University of Dundee Country : Role : Postdoc | Research Scientist
Screening Scientist University of Dundee - UK National Phenotypic Screening Centre Location: Dundee Salary: £30,738 to £37,768 Hours: Full Time Contract Type: Contract / Temporary Placed on: 9th May 2016 Closes: 6th June 2016 Job Ref: SLSC0087
The National Phenotypic Screening Centre (NPSC) was set up by the Scottish Universities Life Science Alliance (SULSA) with a £8M capital funding from the Scottish Government to provide state-of-the-art capabilities in phenotypic assay development and high content screening for academia and enable close collaboration with industry. The main facility is in newly-refurbed labs within the School of Life Sciences research complex at the University of Dundee, with a second smaller screening facility embed in the High throughput lab at the Target Discovery Institute, part of the Nuffield Department of Medicine, University of Oxford. The NPSC has significant screening capabilities that can be applied to human, animal, and plant health and also aims to advance the science of phenotypic screening by building a highly interdisciplinary team.
Job description:
As part of the Phenomics Discovery Initiative the NPSC is now recruiting for a highly-motivated and experienced screening scientist. The successful candidate will be motivated, dynamic, scientifically-excellent problem solvers, reporting to the Director of Operations at the NPSC in Dundee. They will be highly rigorous with an attention to detail whilst being able experimental workers. The successful candidate will be expected to work with other assay development cell biologists and our Lead Platform engineer to advise and steer the develop of 96/384-well cell-based assays in order to achieve the standard required, and then execute screens of compound decks (of between 1,000 and 100,000 compounds), process, analyse and interpret multi-parametric data in conjunction with data/informatics specialists. The position will also require responsibility to assist in compound management/handling and inventory management. Successful candidates will be part of a growing interdisciplinary team and will have the unique opportunity to work closely with industry scientist and academics/clinicians in a state-of-the-art drug discovery facility embedded within a top flight academic research environment.
Main duties and responsibilities:
• Lead the prosecution of phenotypic assays in live and/or fixed-cell systems in 96 and/or 384 well format, ensuring highest levels of quality control.
• Work closely with cell biologists from NPSC-PDi and external academic groups, and therapeutic area leads in our industry partner(s), and clinicians, to assist in the execution of assay development work and guide the development of robust, screen-able phenotypic assays.
• Providing expert opinion on assay robustness to the consortium project team leaders.
• Oversee the PDI’s compound library storage and maintenance to enable the successful execution of screens and delivery to timelines.
• Work with the NPSC’s Lead Platform Engineer to troubleshoot instrument and workflow issues that might impact on data delivery.
• Take responsibility for quality assurance in the screening process.
• Carrying out data analysis and statistical modelling to enable hit selection.
• Keep appropriate experimental records, help oversee data integrity and confidentiality.
• Assist in the production of high quality reports supporting milestones and deliverables.
Your qualifications:
• A PhD (or first degree and MSc/MRes with additional practical experience) in a relevant biological sciences subject or extensive industry experience in a high throughput screening environment.
This position is available for a fixed period of 12 months in the first instance with possibility of renewal.
Type / Role:
Academic or ResearchSubject Area(s):
Biological Sciences Other Biological SciencesLocation(s):
Scotland
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