Job Description:
Would you like to be a part of team advancing clinical genomics and improving medical care for patients facing life threatening diseases? Partners Personalized Medicine is a leader and innovator helping realize the promise of personalized medicine by accelerating the integration of genetic knowledge into clinical care. We are seeking a senior bioinformatician to focus on continuously advancing the state of the art of research and clinical genetic testing. This position offers an opportunity to become a part of a highly engaged team with multiple interactions across the center, including with members of our translational research core, clinical laboratory, biobank, and IT team. Duties will include building robust scalable pipelines and data mining tools for sequencing applications in addition to providing informatics support for the development of clinical diagnostic tests. Applicant will also support many of the large-scale and collaborative grant-funded activities at the center. We are specifically looking for an independent individual who can contribute to multiple projects as part of a highly-integrated team with frequent interactions. A successful candidate should have a strong scientific and quantitative background with prior exposure to genetics and/or genomics, excellent problem-solving and programmatic skills, and the ability to effectively communicate and interact with multidisciplinary staff in a fast-paced environment. Depending upon experience, the candidate may be considered for a Research Associate appointment at Harvard Medical School. Responsibilities: • Responsible for developing and maintaining bioinformatics capabilities to support the activities of the Laboratory for Molecular Medicine (a CLIA-certified molecular diagnostic laboratory), PPM's Translational Genomics Core, and the Partners BioBank, focusing on the development and support of next-generation sequencing pipelines in the research, translational and clinical settings. • Scope, plan, develop, and troubleshoot new modules and pipelines for molecular genetics data. Assign tasks to Associate Bioinformatician(s) as appropriate. • Provide informatics support in development of clinical diagnostic tests using algorithms, scientific programming, and data structures. • Lead the mining/annotation of clinical data thinking of novel approaches and using programming skills while directly interacting with clinical and research staff, including geneticists and genetic counselors. • Help oversee current clinical operation pipelines and research operation pipelines and serve as the primary responsible party for support of these systems, including implementing new approaches to quality assessment and troubleshooting. • Collaborate with and update IT staff to coordinate software releases. Lead the analysis, acquisition, and loading of new data sources, including learning about new resources and vetting their applicability to the task. • Plan projects that assist the bioinformatics team in improving efficiencies and workflows. • Execute established project plans and incorporate alternatives from others when appropriate. • Work directly with development and operation teams to identify and gather requirements for validation of bioinformatics processes. Scope out the validation strategy and identify required resources for validation. Create testing, validation, and standard operation procedure documentation.
Additional Info:
As a not-for-profit organization, Partners HealthCare is committed to supporting patient care, research, teaching, and service to the community by leading innovation across our system. Founded by Brigham and Women’s Hospital and Massachusetts General Hospital, Partners HealthCare supports a complete continuum of care including community and specialty hospitals, a managed care organization, a physician network, community health centers, home care and other health-related entities. Several of our hospitals are teaching affiliates of Harvard Medical School, and our system is a national leader in biomedical research. We’re focused on a people-first culture for our system’s patients and our professional family. That’s why we provide our employees with more ways to achieve their potential. Partners HealthCare is committed to aligning our employees’ personal aspirations with projects that match their capabilities and creating a culture that empowers our managers to become trusted mentors. We support each member of our team to own their personal development—and we recognize success at every step. Our employees use the Partners HealthCare values to govern decisions, actions and behaviors. These values guide how we get our work done: Patients, Affordability, Accountability & Service Commitment, Decisiveness, Innovation & Thoughtful Risk; and how we treat each other: Diversity & Inclusion, Integrity & Respect, Learning, Continuous Improvement & Personal Growth, Teamwork & Collaboration. EEO Statement Partners HealthCare is an Equal Opportunity Employer & by embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. [Click Here to Access the Original Job Post]
Would you like to be a part of team advancing clinical genomics and improving medical care for patients facing life threatening diseases? Partners Personalized Medicine is a leader and innovator helping realize the promise of personalized medicine by accelerating the integration of genetic knowledge into clinical care. We are seeking a senior bioinformatician to focus on continuously advancing the state of the art of research and clinical genetic testing. This position offers an opportunity to become a part of a highly engaged team with multiple interactions across the center, including with members of our translational research core, clinical laboratory, biobank, and IT team. Duties will include building robust scalable pipelines and data mining tools for sequencing applications in addition to providing informatics support for the development of clinical diagnostic tests. Applicant will also support many of the large-scale and collaborative grant-funded activities at the center. We are specifically looking for an independent individual who can contribute to multiple projects as part of a highly-integrated team with frequent interactions. A successful candidate should have a strong scientific and quantitative background with prior exposure to genetics and/or genomics, excellent problem-solving and programmatic skills, and the ability to effectively communicate and interact with multidisciplinary staff in a fast-paced environment. Depending upon experience, the candidate may be considered for a Research Associate appointment at Harvard Medical School. Responsibilities: • Responsible for developing and maintaining bioinformatics capabilities to support the activities of the Laboratory for Molecular Medicine (a CLIA-certified molecular diagnostic laboratory), PPM's Translational Genomics Core, and the Partners BioBank, focusing on the development and support of next-generation sequencing pipelines in the research, translational and clinical settings. • Scope, plan, develop, and troubleshoot new modules and pipelines for molecular genetics data. Assign tasks to Associate Bioinformatician(s) as appropriate. • Provide informatics support in development of clinical diagnostic tests using algorithms, scientific programming, and data structures. • Lead the mining/annotation of clinical data thinking of novel approaches and using programming skills while directly interacting with clinical and research staff, including geneticists and genetic counselors. • Help oversee current clinical operation pipelines and research operation pipelines and serve as the primary responsible party for support of these systems, including implementing new approaches to quality assessment and troubleshooting. • Collaborate with and update IT staff to coordinate software releases. Lead the analysis, acquisition, and loading of new data sources, including learning about new resources and vetting their applicability to the task. • Plan projects that assist the bioinformatics team in improving efficiencies and workflows. • Execute established project plans and incorporate alternatives from others when appropriate. • Work directly with development and operation teams to identify and gather requirements for validation of bioinformatics processes. Scope out the validation strategy and identify required resources for validation. Create testing, validation, and standard operation procedure documentation.
Qualifications
Required: • Advanced degree (PhD or equivalent) in bioinformatics or related field preferred (computer science, computational biology, etc). MS degree may be considered depending on level of relevant experience •At least 3 years of coding experience with Perl or Python in a UNIX/Linux environment • Proficiency in shell scripting and in submitting jobs in a HPC environment • Experience with creating and managing databases • Experience with common bioinformatics databases and genome browsers • Understanding and usage of biostatistics and bioinformatics tools, including common NGS tools (e.g. BWA, samtools, Picard, GATK) and statistical/visualization packages (e.g. R, Bioperl, MATLAB) • Ability to work with others to set realistic goals and deliver quality work, on schedule, and with minimal supervision Additional Qualifications (Pluses): • Experience with Java and/or building web sites for presenting experimental results • Experience with machine learning algorithms • Experience with automation for analysis of large, complex data sets • Strong interpersonal skills and ability to work as part of a diverse team, while contributing to a high-quality and respectful work environment • Excellent oral and written communication skillsRequeriments :
Skills :
- Bioinformatics Databases
- Biostatistics
- Database design
- Genetics
- genomic
- HPC
- Lunix/Unix
- Machine Learning
- Next Generation Sequencing
- Programing in Python
- Programing Skills
- Programming in Java
- Programming in Matlab
- Programming in PERL
- Programming in R
- Shell scripting
Areas :
Additional Info:
As a not-for-profit organization, Partners HealthCare is committed to supporting patient care, research, teaching, and service to the community by leading innovation across our system. Founded by Brigham and Women’s Hospital and Massachusetts General Hospital, Partners HealthCare supports a complete continuum of care including community and specialty hospitals, a managed care organization, a physician network, community health centers, home care and other health-related entities. Several of our hospitals are teaching affiliates of Harvard Medical School, and our system is a national leader in biomedical research. We’re focused on a people-first culture for our system’s patients and our professional family. That’s why we provide our employees with more ways to achieve their potential. Partners HealthCare is committed to aligning our employees’ personal aspirations with projects that match their capabilities and creating a culture that empowers our managers to become trusted mentors. We support each member of our team to own their personal development—and we recognize success at every step. Our employees use the Partners HealthCare values to govern decisions, actions and behaviors. These values guide how we get our work done: Patients, Affordability, Accountability & Service Commitment, Decisiveness, Innovation & Thoughtful Risk; and how we treat each other: Diversity & Inclusion, Integrity & Respect, Learning, Continuous Improvement & Personal Growth, Teamwork & Collaboration. EEO Statement Partners HealthCare is an Equal Opportunity Employer & by embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. [Click Here to Access the Original Job Post]