Job ID: 16001131
Job date: 2017-02-21
End Date:
Company : Celgene Corporation Country : Role : Research Scientist
Job date: 2017-02-21
End Date:
Company : Celgene Corporation Country : Role : Research Scientist
Job Description:
The Celgene Protein Homeostasis Thematic Center is seeking a translational investigator with the capability to define and implement preclinical and clinical translational strategies for novel agents entering clinical development. Deep scientific expertise in cancer biology and direct experience with clinical-stage correlative and translational support for novel agents is required. This individual will play a key scientific role in program strategy supporting dose and schedule, indication selection, patient selection, and PD samples and endpoints to inform and enable development of novel agents in Celgene’s Research and Early Development organization. The role will focus on agents targeting protein stability and function. Significant experience evaluating and deploying technologies in genome, transcriptome, and proteome characterization to clinical samples and data, and demonstrated success in deriving novel biological information and insight into clinical outcomes from such data, is required. The position will require an individual with established scientific leadership ability and excellent communication and collaboration skills. Applications are encouraged from those looking to bridge the capabilities and strengths of academic and industrial research environments to enable the development of truly innovative, life-changing therapies. As a member of an integrated discovery research and early development team, this role will also involve collaboration with discovery biology and chemistry researchers, clinicians, and computational biologists. A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful. We are particularly interested to hear from individuals with deep knowledge and skills in genetic and protein interaction networks and pathway dependencies. In particular, a knowledge of pathways relevant to oncology would be helpful. This position will report to the Translational Leader of the Protein Homeostasis Thematic center of Excellence, and will be located in San Diego, California. Exceptional candidates who are geographically constrained to the San Francisco region may also be considered. Key Responsibilities: · Translational science leader in the context of early-phase clinical trials · Manage the selection, validation, and deployment of novel clinical-stage assay methods and analysis of data to accelerate development and provide insight into disease biology and drug mechanisms · Design and interpret experiments to define dose-schedules, patient selection markers and other biomarker readouts, combination strategies and pathways of drug resistance for oncology programs · Design and oversee execution of experiments to test hypotheses from clinical observations in preclinical model systems · Author and oversee writing of study reports, patents, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards · Provide scientific leadership on cross-site and cross-functional teams · Present work at governance committees, internal forums, and external meetings · Lead the planning and execution of collaborative projects with leading academic and commercial research groups worldwide. · Supervise contract research organizations to achieve high standards of productivity and quality. · Manage projects to successful outcomes through scientific leadership, teamwork and influence, and potentially direct reporting relationships · Mentor research staff through instruction, coaching, and guidance · Work across geographies and scientific domains. Qualifications: Ph.D. in a relevant field (Biology, Computational Biology, Biochemistry) with at least 15 years of relevant work experience, required. Pharmaceutical industry experience is preferred. Skills/Knowledge Required: · Expert in clinical translational studies including sampling, analysis, and interpretation of multiple data types including NGS/ omic data ·Experienced translational leader able to define program priorities and strategies ·Comprehensive knowledge of cancer biology and drug development ·Proven ability to derive novel insights from complex data · Ability to interpret and summarize scientific data in an accurate, critical and concise manner · Strong understanding, derived from direct participation, of the design and execution of clinical trials incorporating translational science and correlative endpoints · Expertise in biomarker discovery and development, with advanced skills in assay design, development, validation, and troubleshooting ·Experienced in the integration of preclinical research through to clinical drug development · Highly effective teamwork and interpersonal skills · Exceptional written and verbal communications skills. ·Broad understanding of the R&D process. ·Functional group advisor/go-to person. ·Demonstrate broad understanding of Drug Discovery & Development. · Able to assess risk & develop contingency plans. · Recognized as expert in the field. · Serves as subject matter expert and functional group advisor on science, technology, methods, etc. · Familiar with basic business principles and focus of corporation. · Uses this knowledge to drive projects. Tasks and Responsibilities: • Has accountability for scientific strategies and timelines. • Prioritizes risks and recommend or endorse contingency plans. • Developing others beyond functional expertise. • Viewed as subject matter expert across multiple scientific subjects. • Responsible for internal and external resources. • Coordinate cross functional activities. • Role model for scientific culture. • Develop cross functional strategy. • Communicate and make recommendations to line management. Discretion/Latitude: • Develops cross functional strategies. • Held accountable for cross functional strategies. • May develop cross functional policies. • Make recommendations to Senior Management and larger scientific community. • Guide/mentor/develop others in broad area of influence. • Functional leadership. Creativity and Problem Solving: • Develop scientific directions for projects (strategy). • Acts as a resource to peers in developing new, innovative approaches to experimental design. • Independently (or using collaborations) develop scientific direction for assignments. • Recognize cross-functional issues. • Proposes innovative ideas to enhance Drug Discovery processes. Teamwork and Influence: • Communicates within the larger organization and external community. • Provides expert guidance to multi-disciplinary teams and senior management. Organizational Impact: • Direct impact on the performance of multiple departments. • Impact is achieved through leading workgroups and contributing to cross-functional teams. • Leader who influences culture & values. • Able to conceptualize broad impact of research programs and personal activities in terms of whole organization. Behavioral Competencies: • Champions change • Leads courageously • Networking • Provides directions • Structuring and staffing • Thinks strategically
Additional Info:
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture. Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.[Click Here to Access the Original Job Post]
The Celgene Protein Homeostasis Thematic Center is seeking a translational investigator with the capability to define and implement preclinical and clinical translational strategies for novel agents entering clinical development. Deep scientific expertise in cancer biology and direct experience with clinical-stage correlative and translational support for novel agents is required. This individual will play a key scientific role in program strategy supporting dose and schedule, indication selection, patient selection, and PD samples and endpoints to inform and enable development of novel agents in Celgene’s Research and Early Development organization. The role will focus on agents targeting protein stability and function. Significant experience evaluating and deploying technologies in genome, transcriptome, and proteome characterization to clinical samples and data, and demonstrated success in deriving novel biological information and insight into clinical outcomes from such data, is required. The position will require an individual with established scientific leadership ability and excellent communication and collaboration skills. Applications are encouraged from those looking to bridge the capabilities and strengths of academic and industrial research environments to enable the development of truly innovative, life-changing therapies. As a member of an integrated discovery research and early development team, this role will also involve collaboration with discovery biology and chemistry researchers, clinicians, and computational biologists. A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful. We are particularly interested to hear from individuals with deep knowledge and skills in genetic and protein interaction networks and pathway dependencies. In particular, a knowledge of pathways relevant to oncology would be helpful. This position will report to the Translational Leader of the Protein Homeostasis Thematic center of Excellence, and will be located in San Diego, California. Exceptional candidates who are geographically constrained to the San Francisco region may also be considered. Key Responsibilities: · Translational science leader in the context of early-phase clinical trials · Manage the selection, validation, and deployment of novel clinical-stage assay methods and analysis of data to accelerate development and provide insight into disease biology and drug mechanisms · Design and interpret experiments to define dose-schedules, patient selection markers and other biomarker readouts, combination strategies and pathways of drug resistance for oncology programs · Design and oversee execution of experiments to test hypotheses from clinical observations in preclinical model systems · Author and oversee writing of study reports, patents, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards · Provide scientific leadership on cross-site and cross-functional teams · Present work at governance committees, internal forums, and external meetings · Lead the planning and execution of collaborative projects with leading academic and commercial research groups worldwide. · Supervise contract research organizations to achieve high standards of productivity and quality. · Manage projects to successful outcomes through scientific leadership, teamwork and influence, and potentially direct reporting relationships · Mentor research staff through instruction, coaching, and guidance · Work across geographies and scientific domains. Qualifications: Ph.D. in a relevant field (Biology, Computational Biology, Biochemistry) with at least 15 years of relevant work experience, required. Pharmaceutical industry experience is preferred. Skills/Knowledge Required: · Expert in clinical translational studies including sampling, analysis, and interpretation of multiple data types including NGS/ omic data ·Experienced translational leader able to define program priorities and strategies ·Comprehensive knowledge of cancer biology and drug development ·Proven ability to derive novel insights from complex data · Ability to interpret and summarize scientific data in an accurate, critical and concise manner · Strong understanding, derived from direct participation, of the design and execution of clinical trials incorporating translational science and correlative endpoints · Expertise in biomarker discovery and development, with advanced skills in assay design, development, validation, and troubleshooting ·Experienced in the integration of preclinical research through to clinical drug development · Highly effective teamwork and interpersonal skills · Exceptional written and verbal communications skills. ·Broad understanding of the R&D process. ·Functional group advisor/go-to person. ·Demonstrate broad understanding of Drug Discovery & Development. · Able to assess risk & develop contingency plans. · Recognized as expert in the field. · Serves as subject matter expert and functional group advisor on science, technology, methods, etc. · Familiar with basic business principles and focus of corporation. · Uses this knowledge to drive projects. Tasks and Responsibilities: • Has accountability for scientific strategies and timelines. • Prioritizes risks and recommend or endorse contingency plans. • Developing others beyond functional expertise. • Viewed as subject matter expert across multiple scientific subjects. • Responsible for internal and external resources. • Coordinate cross functional activities. • Role model for scientific culture. • Develop cross functional strategy. • Communicate and make recommendations to line management. Discretion/Latitude: • Develops cross functional strategies. • Held accountable for cross functional strategies. • May develop cross functional policies. • Make recommendations to Senior Management and larger scientific community. • Guide/mentor/develop others in broad area of influence. • Functional leadership. Creativity and Problem Solving: • Develop scientific directions for projects (strategy). • Acts as a resource to peers in developing new, innovative approaches to experimental design. • Independently (or using collaborations) develop scientific direction for assignments. • Recognize cross-functional issues. • Proposes innovative ideas to enhance Drug Discovery processes. Teamwork and Influence: • Communicates within the larger organization and external community. • Provides expert guidance to multi-disciplinary teams and senior management. Organizational Impact: • Direct impact on the performance of multiple departments. • Impact is achieved through leading workgroups and contributing to cross-functional teams. • Leader who influences culture & values. • Able to conceptualize broad impact of research programs and personal activities in terms of whole organization. Behavioral Competencies: • Champions change • Leads courageously • Networking • Provides directions • Structuring and staffing • Thinks strategically
Requeriments :
Skills :
Areas :
Additional Info:
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture. Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.[Click Here to Access the Original Job Post]