Job Description:
The candidate for Design Sciences will develop and immediately apply novel machine learning and computational structural biology-based approaches for vaccine R&D at Sanofi Pasteur. The candidate will operate within the newly formed FluNeXt “Biotech” within Sanofi Pasteur. S/he will be responsible for developing novel methods to address state-of-the-art problems in computational structural biology. As an example, the candidate will work closely with internal and external (e.g. government, academic, external contractor) groups to develop structural understanding of the influenza virus, its antigenic and structural proteins (especially hemagglutinin and neuraminidase). The candidate should have a solid understanding of fundamentals in biophysics, thermodynamics, etc. and should be adept at comprehending those data through the lens of machine learning (e.g., how would one quantitatively associate intrinsic dynamics of related proteins to differences in their function). The candidate preferably also has bench experience in Biochemistry, X-ray Crystallography or Electron Microscopy so that s/he can effectively collaborate with the experimental team (s) as part of our internal R&D efforts. S/he will have an advanced understanding and practical experience with developing and applying complex machine learning solutions for structural biology data. S/he will have had hands-on experience covering advanced algorithms, databases, networking, modeling and simulation, as well as those covering biocomputation and bioengineering informatics, as well as essential scientific programming skills (e.g. in languages such as Python/R and the like). It is expected that the candidate is proficient at general computational biology tasks (e.g. to manipulate sequence alignments for homology modeling). S/he is expected to have a broad based scientific training (PhD, MD, BioEngineer, Bioinformatics, Computational Biology or Master’s degree with equivalent experience), to be multidisclipinary in nature, with an interdisciplinary specialization focusing on computational challenges and solutions in the biological and structural biology application areas. Ideally s/he will leverage previously acquired industrial experience, and be ready to hit the ground running in a tight knit, fast paced environment that rewards personal initiative, collaboration, and scientific excellence.
Additional Info:
Sanofi is a global healthcare leader focused on patients' needs, engaged in the research, development, manufacturing and marketing of therapeutic solutions focused on patients’ needs. Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets and Sanofi Genzyme. At Sanofi, our ambition is to be an integrated global healthcare company, focused on patients’ needs. Much more than just a leading pharmaceutical company, Sanofi is committed to transforming scientific innovations into solutions and services that protect health, enhance life, and respond to the needs of the 7 billion people in the world. We trust our ambition to guide and inspire us as we work to create a future with optimal health and wellness for everyone.[Click Here to Access the Original Job Post]
The candidate for Design Sciences will develop and immediately apply novel machine learning and computational structural biology-based approaches for vaccine R&D at Sanofi Pasteur. The candidate will operate within the newly formed FluNeXt “Biotech” within Sanofi Pasteur. S/he will be responsible for developing novel methods to address state-of-the-art problems in computational structural biology. As an example, the candidate will work closely with internal and external (e.g. government, academic, external contractor) groups to develop structural understanding of the influenza virus, its antigenic and structural proteins (especially hemagglutinin and neuraminidase). The candidate should have a solid understanding of fundamentals in biophysics, thermodynamics, etc. and should be adept at comprehending those data through the lens of machine learning (e.g., how would one quantitatively associate intrinsic dynamics of related proteins to differences in their function). The candidate preferably also has bench experience in Biochemistry, X-ray Crystallography or Electron Microscopy so that s/he can effectively collaborate with the experimental team (s) as part of our internal R&D efforts. S/he will have an advanced understanding and practical experience with developing and applying complex machine learning solutions for structural biology data. S/he will have had hands-on experience covering advanced algorithms, databases, networking, modeling and simulation, as well as those covering biocomputation and bioengineering informatics, as well as essential scientific programming skills (e.g. in languages such as Python/R and the like). It is expected that the candidate is proficient at general computational biology tasks (e.g. to manipulate sequence alignments for homology modeling). S/he is expected to have a broad based scientific training (PhD, MD, BioEngineer, Bioinformatics, Computational Biology or Master’s degree with equivalent experience), to be multidisclipinary in nature, with an interdisciplinary specialization focusing on computational challenges and solutions in the biological and structural biology application areas. Ideally s/he will leverage previously acquired industrial experience, and be ready to hit the ground running in a tight knit, fast paced environment that rewards personal initiative, collaboration, and scientific excellence.
Requeriments :
Skills :
- Biochemistry
- Computational Biology
- Machine Learning
- Modeling
- Programing in Python
- Programing Skills
- Programming in R
Areas :
Additional Info:
Sanofi is a global healthcare leader focused on patients' needs, engaged in the research, development, manufacturing and marketing of therapeutic solutions focused on patients’ needs. Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets and Sanofi Genzyme. At Sanofi, our ambition is to be an integrated global healthcare company, focused on patients’ needs. Much more than just a leading pharmaceutical company, Sanofi is committed to transforming scientific innovations into solutions and services that protect health, enhance life, and respond to the needs of the 7 billion people in the world. We trust our ambition to guide and inspire us as we work to create a future with optimal health and wellness for everyone.[Click Here to Access the Original Job Post]