Job date: 2015-05-08
End Date:
Company : Wellcome Trust Sanger Institute Country : Role : Postdoc
Salary range: £30196 to £38088 per annum plus excellent benefits
An exciting opportunity has become available at the Wellcome Trust Sanger Institute for a highly-motivated, self-driven Senior Research Assistant (SRA)/Lab Manager to set up and manage the high throughput screening laboratory in a newly established group led by Dr. Leopold Parts.
Our group’s broader goal is to measure, model, and modulate cellular state. Our previous research has attacked problems in diverse areas of genomics: developing models for mRNA expression genetics, quantifying and mapping small RNA abundance, inferring cellular traits, measuring and mapping protein levels, quantifying genetic screens, and mapping complex phenotypes. These studies have led to the ongoing work on CRISPR/Cas9 based screens. The first aim of our new group is to apply this approach to cellular traits in a mammalian system.
Your goal as a successful SRA is to work with other team members to develop and apply high throughput screening protocols, and to perform follow-up experiments on the results. These tasks include cloning and transfecting reporter constructs, creating genetically modified cell lines for screening, cloning and transducing lentiviral libraries, performing cell culture, establishing screening protocols, and testing new approaches. The successful candidate will be responsible for setting up and organising all facets of the laboratory environment, supervising general workflow for high throughput experiments on a day-to-day basis, and ensuring high quality scientific output is produced while adhering to the safety requirements
We are seeking someone with strong research interests who will be actively involved in planning large-scale experiments, and leading their execution. You will possess the ability to get things done quickly and efficiently, while budgeting sufficient time for documenting the work, and keeping up with relevant literature. To function effectively in our multidisciplinary, collaborative setting, you have to be able to communicate well with scientists from diverse backgrounds, including trainees and computational researchers, and be a pleasant colleague.
The position offers an opportunity to work at one of the world-leading genomic research centres and to participate in the development and application of experimental techniques at the forefront of current genomic research. We are part of a dynamic and collaborative environment at the Genome Campus and you will work closely with the group leader and a Postdoctoral Fellow. You will have the chance to interact with other researchers across the Institute, especially in the Cellular Genetics and Human Genetics programmes.
Essential Skills
Interest in science; ability to get things done. Degree in Biological Sciences, or equivalent qualification. Substantial previous work experience in a molecular biology laboratory, ideally in transgenics and high-throughput screening environments. Extensive experience of core molecular and cell biology techniques: molecular cloning, DNA/RNA extraction, RT & qPCR, mammalian cell culture, creating stable transgenic lines, transfection and viral transduction, high throughput genetic screens, and ideally, high throughput microscopy and robotics setups. Ability to independently develop, optimize and deploy research support, as a member of a closely collaborative team. Good degree of computer literacy; competence with Microsoft office packages. Effective and self-motivated team worker, communicator, and task manager.Other information
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.
The Institute is located near Cambridge, UK on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.
To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.
Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Please provide a CV and cover letter.
Informal enquiries to: leopold.parts@sanger.ac.uk
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