Job Area: Computational Biology
Moderna is seeking an exceptionally talented and highly motivated bioinformatician with a broad skill base to work as part of a highly collaborative, multi-disciplinary, and fast-paced team. Moderna s mission to develop mRNA therapeutics means that this position will be responsible for a wide range of projects, from comprehensive investigation of individual targets to efficient and concise analysis of large data sets. The successful candidate will work closely with the team to develop and apply bioinformatics tools and resources in support of numerous R&D projects and therapeutic programs. [More]
Modified DNA bases play an important epigenetic role in the regulation of gene expression in development and disease. In mammals there are four different cytidine modifications in genomic DNA known to have an epigenetic function, most prominently 5-hydroxymethylcotosine. There are many more known DNA modifications, whose function remain unknown and await characterization, including of the cellular enzymes that affect these modifications, which will be the aim of the project. Our lab has a broad expertise not only in molecular cell biology and bioinformatics, but in bioanalytical chemistry, where we are using LC/MS/MS detection for modified nucleobases. Beyond mass spectrometry analysis, we will knockout candidate genes in mouse embryonic stem cells (mESCs) by the CRISPR/Cas9 genome editing technique and analyze the physiological relevance of these genes in pluripotency and during mESC in vitro differentiation by e.g. RNA sequencing. Given the biological importance of the new DNA modification, the project promises to be ground breaking, opening unexplored fields in epigenetics. This PhD project will be particularly suited for students with interest in biochemistry and/or bioorganic analytical methods, particularly mass spectrometry. [More]
Applications are invited for two Postdoctoral positions in the Ismagilov group at the California Institute of Technology. Appointees will work on an NIHfunded collaborative project between the Ismagilov and Guttman labs to study the 3-dimensional structure of nuclei in single cells across time using a combination of microfluidic technologies and molecular biology techniques. PD #1 – MOLECULAR will develop methods to comprehensively map DNA-DNA, DNA-RNA, and RNA-RNA interactions within the nucleus, as well as help implement those methods in microfluidic devices for the study of single cells. Required skills for PD #1 include: molecular biology and biochemistry and familiarity with sequencing and bioinformatics. PD #2 – MICROFLUIDICS will develop and refine microfluidic devices for performing multi-step biochemical protocols on individual cells and nuclei in order to comprehensively map DNA-DNA, DNA-RNA, and RNA-RNA interactions within the nucleus. Required skills for PD #2 include: strong background in fundamentals of microfluidics, with experience in biochemistry and molecular and cell biology in microfluidic devices. All applicants must have demonstrated a published record of creativity, depth, and accomplishment. Experience with single-cell methodologies and associated challenges is considered a plus. Candidates should send toismagilov.postdoc@caltech.edu a CV and a brief statement of research interests. [More]
We are looking for a motivated candidate with an academic background and an interest in developing the skills to manage projects independently. The role requires creative thinking, excellent developer and communication skills in an international environment and a ‘can-do’ philosophy. You will contribute to the planning and development of an integrative single entry point solution for 13 European research infrastructures to offer access to their resources in a cross-platform model. You will co-ordinate with both the developer of the Instruct web-based systems and the technical teams of other related projects. [More]
We are looking for a highly motivated PhD with a strong background in bioinformatics/computational biology. The project concerns the mechanisms underlying the functional diversification of human natural killer cells. Studies of immunological diversity in populations are combined with the integration and analysis of high-dimensional single-cell data generated by RNASeq, flow cytometry and CyTOF. The candidate will work at the interface of immunology, cancer and bioinformatics. Immune informatics is a nascent field with many challenging computational tasks ahead. The candidate, together with colleagues, will particularly focus on computational approaches toward clinically relevant immune profiling of immune-cell repertoires in patients. Depending on qualifications of the applicant, the position may offer the possibility to develop an independent line of research within the overall scope of the groups research program. [More]
Undisclosed: The Department of Bioinformatics and Genomics at the University of North Carolina at Charlotte: We seek applicants wishing to develop a research program in bioinformatics, computational biology and/or computational genomics. Charlotte, North Carolina (US) [More]
Commensurate with Experience: Johns Hopkins University, SKCCC: Seeking Computational Biologist/Bioinformatics for epigenetics projects. RO1 funded lab in epigenetics of pancreatic and colorectal cancer. Baltimore, Maryland (US) [More]
Competitive: St. Jude Children's Research Hospital: The Computational Biology (Comp. Bio) Department at St. Jude Children’s Research Hospital (SJCRH) is seeking a highly motivated Bioinformatics Research Scientist to work on familial cancer studies in conjunction with investigators from Division of Cancer Memphis, Tennessee [More]
Competitive: St. Jude Children's Research Hospital: The Bioinformatics Research Scientist participates in method development, data analysis, statistical analysis, experimental and analytical design and data management for an immunology program working on T cell biology (including TCR repertoire), influenz Memphis, Tennessee [More]
Competitive: St. Jude Children's Research Hospital: We are seeking a Bioinformatics Research Scientist to participate in collaborative projects between the Department of Computational Biology and the laboratory of Dr. Mitchell Weiss in the Department of Hematology. The Weiss Lab focuses on mechanisms of n Memphis, Tennessee [More]