Job Company: Helmholtz Zentrum München

Currently there is the opportunity to join our team as a PhD student (m/f) – in Imaging Mass spectrometry 2017/0324. Working in a scientific project funded by the German research Foundation (DFG) with the focus on investigation of therapy prediction of cancer; Applying high resolution imaging mass spectrometry (MALDI TOF IMS und MALDI FTMS IMS) of tissues; Focus on in situ melabolomic analysis...  [More]

The Helmholtz Zentrum München in Munich, Germany, is member of one of the leading research associations in Europe - the Helmholtz Association of German Research Centers. The aim of our research is to proactively detect health risks involving humans and the environment, decoding the mechanisms of pathogenesis and developing concepts for prevention and therapy.  Idiopathic pulmonary fibrosis is characterized by altered cell composition and homeostasis leading to loss of function (Fernandez et al, Lancet 2012;380:680-88). To find anti-fibrotic strategies understanding cellular processes of disease development is crucial. Recently, we started this by identifying dynamics of biological processes and networks on the proteomic level (Schiller et al, Molecular Systems Biology 2015;11:819). Based on our recent works on the analysis of single cell transcriptomics to correct for latent confounders such as cell cycle (Buettner et al, Nature Biotechnology 2015;33:155-160) and to visualize developmental processes (Haghverdi et al, Bioinformatics 2015; 31:2989-2998), we want to model and analyze the transcriptional heterogeneity linked to disease pathomechanisms and disease classification by single-cell analysis.  The Institute of Computational Biology (ICB) offers in cooperation with the Institute for Lung Biology and Disease (Comprehensive Pneumology Center, CPC) a position at the earliest possible date for a  PostDoc in Single-cell Bioinformatics/ Computational Biology (2015/2935)   Job Description: - single-cell-analysis - quantitative description and modeling of disease-related networks - modeling and analysis of heterogeneous gene expression Our Offer: - Working in an innovative, well-equipped and scientifically stimulating   surrounding - Further training opportunities - Initial short-term employment contract for two years with a standard public   service salary (TV EntgO Bund EG 13)  [More]