Job Company: University Hospital RWTH Aachen

The Institute for Biomedical Engineering – Cell Biology at RWTH Aachen University Medical School is offering a position for a Bioinformatic Scientist (PhD Student or Postdoc; m/f) starting as soon as possible. We offer a position, which is initially limited for 2 years with the option for extension. The salary is based on the German public service salary scale (TV-L). We are analyzing mechanisms of cellular differentiation in various types of stem cells – particularly embryonic stem cells, induced pluripotent stem cells, hematopoetic stem cells, mesenchymal stem cells, and dendritic cells. To this end, we are using own and public datasets that were generated by next generation sequencing (e.g. DNA-Seq, Chip-Seq, RNA-Seq) or microarrays (gene expression arrays and DNA-methylation platforms). The position is for a talented and motivated bioinformatics scientist that interacts closely with Wet-lab scientists of the groups of Prof. Martin Zenke (http://www.molcell.rwth-aachen.de) and Prof. Wolfgang Wagner (www.stemcellbiology.ukaachen.de). Particular focus is on epigenetic changes – e.g. histone modifications or DNA-methylation changes during differentiation, disease and aging. The lab will also validate and address bioinformatics hypotheses by genome editing technologies, such as CRISPR/Cas. Furthermore, bioinformatics research will be performed in collaboration with our colleagues at the IZKF Research Group Computational Biology (Dr. Ivan Costa; http://costalab.org) and the Joined Research Center for Computational Biomedicine at RWTH Aachen University (Professors Andreas Schuppert and Julio Saez-Rodriguez; www.combine.rwth-aachen.de) – thus, there is an excellent environment for your research.  [More]

The Bioinformatics Group RWTH Aachen University performs research on computational epigenomic methods. Over the past years, we have developed methods for prediction of cell specific binding sites from DNAse-Seq data (Gusmao et al., Bioinformatics, 2014; Gusmao et al., Nature Methods, 2016) and epigenetic and regulatory networks driving cell differentiation via integrative analysis of ChIP-Seq and RNA-Seq data (Allhoff et al., Bioinformatics, 2015; Lin et al., NAR, 2015). We invite applicants for Phd Candidate and Postdoctoral positions in Computational Epigenomics. Candidates will perform research on methods for analysis of single cell epigenomics as ATAC-Seq, DNAse-seq and ChIP-Seq. These projects will be performed in collaboration with stem cell and medical specialists from the RWTH Aachen University.  [More]