Job Company: Wellcome Trust Sanger Institute
We are looking for a senior C software developer to work on samtools, one of the world's most popular bioinformatics software packages. Our research in DNA and genetics produces a huge volume of data which produces many technical challenges in efficient processing and interpretation. By joining us you will help samtools meet these requirements. [More]
We are looking for a Software Developer (or Senior Software Developer depending on experience) to work in Dr. Gosia Trynka’s team at the Wellcome Trust Sanger Institute. Our group is an interactive mix of experimental and computational researchers. We combine immunology and genomic assays to understand the role of genetic variants in predisposing to development of immune diseases.We use computational and statistical methods to analyze large genomic datasets to better understand the causes of a wide range of human disorders. [More]
We seek a Post-Doctoral Fellow/ Computational Biologist to join the Analytical Genomics of Complex Traits team on an exciting multi-omics project to characterise the biological processes underpinning osteoarthritis progression. In this position you will take a leading scientific role in a large-scale project that will combine methylation, chromatin immunoprecipitation sequencing, capture Hi-C, RNA sequencing, quantitative proteomics and whole genome sequencing data from disease-relevant patient tissue samples [More]
We seek a Post-Doctoral Fellow/ Computational Biologist to join the Analytical Genomics of Complex Traits team on an exciting multi-omics project to characterise the biological processes underpinning osteoarthritis progression. In this position you will take a leading scientific role in a large-scale project that will combine methylation, chromatin immunoprecipitation sequencing, capture Hi-C, RNA sequencing, quantitative proteomics and whole genome sequencing data from disease-relevant patient tissue samples. [More]
The Experimental Cancer Genetics group at the Wellcome Trust Sanger Institute are seeking an experienced Biostatistician/Bioinformatician to contribute to the characterisation of mutational signatures and mutational landscapes from the genomes and epigenomes of lung tumours induced by carcinogen exposure. [More]
The Wellcome Trust Sanger Institute, a world leader in genetic research, is looking for an exceptional Computational Biologist (Staff Scientist) to work on host-pathogen interactions. The successful candidate will join an interdisciplinary team of laboratory scientists, computational biologists and bioinformatics to develop innovative analysis tools and to lead on the biological analysis of large datasets. The role will be based within the Institute’s Malaria Programme (Dr. Oliver Billker), but we are looking for a talented individual who can provide an effective interface with our other Programmes in Cellular Genetics and Computational Biology, in particular the Single Cell Initiative (Dr. Sarah Teichmann and others). Ongoing large-scale projects range from screening libraries of in vitro differentiated stem cells for interactions with a panel of pathogens, to single cell transcriptomics of malaria parasite development and immunity. For informal inquiries you may contact Dr. Oliver Billker (ob4@sanger.ac.uk). [More]
The Wellcome Genome Campus has been at the forefront of genetic and genomic research since its inception, when it played a key role in the successful completion of the Human Genome Project. The Human Cell Atlas is a new generation of international collaborative genome-scale project focused on comprehensive sequencing of human cells and tissues at the resolution of individual cells with single cell transcriptomics. This is an exceptional opportunity, at a scientifically fascinating moment in time, to build a team focused on profiling human cells and tissues using single cell genomics techniques coupled with computational analysis. Exciting recent advances in high-throughput single cell genomics have made a systematic, high-resolution map of cell in the human body a realistic prospect. This will offer unprecedented insights into biological processes and provide a new level of understanding of human health and disease. The project lends itself to a modular workflow consisting of three elements: sample collection (including cell disaggregation and sorting), genomics and bioinformatics. These three elements will be supported by a team of wet and dry lab staff, brought together by an overarching management structure comprised of a Principal Staff Scientist who will be assisted by a Project Coordinator. Communication skills in order to ensure fruitful interactions with faculty within and outside Sanger/UK will be key to the success of the Principal Staff Scientist in this role. You will be passionate about science and research, able to lead and develop a team of wet and dry lab scientists, and a natural collaborator who can build new partnerships and networks. You will play a key role in driving forward this exciting and ambitious genomics project over the next five to ten years. [More]
Postdoctoral Fellow - Senior Bioinformatician Salary range: £30655 to £38428pa plus excellent benefits Fixed-term for 3 years We are looking for a creative, motivated and collaborative bioinformatician/postdoctoral scientist to join the Host-Microbiota Interactions Laboratory (www.lawleylab.com) investigating interactions between host and microbiota during health and disease. The group has projects focused on infectious diseases, antibiotic therapies, autoimmune diseases and early life colonization. The lab is very collaborative and consists of microbiologists, bioinformaticians, cell biologists and mouse biologists so there is ample capacity for the individual to develop new skill sets. The group is well resourced giving the individual access to cutting edge genomic and proteomic tools (host and microbiota), human organoids, transgenic mice, germ free mice, a human microbiota bacterial culture collection and state of the art anaerobic culturing facility. The lab is focused on translational science with links to the biotech industry. The Lawley Lab has developed unique capabilities to culture the majority of bacteria in the human intestinal microbiota (Browne et al. 2016. Nature). The Lab maintains an extensive bacterial culture collection of >300 species and has sequenced all species to generate reference genome database (Forster et al. 2016. NAR). The individual will use advanced genomic analysis methods and generally focus on establishing the phylogenies and accessory genomes of dominant bacterial clades the human intestinal microbiota to assist in identifying functional attributes of bacteria that promote health. This is a unique position as the project leverages a comprehensive human microbiota culture collection and associated genomic data combined with cutting edge laboratory culturing and animal model facilities in a world leading genome research institute. The applicant should have a strong background in bioinformatics, a knowledge of microbiology and have an interest in learning about host-pathogen interactions and the biology of host-associated microbial communities during health and disease. Key Responsibilities include: Manage and analyse large-scale whole-genome sequencing datasets and their associated projects Perform analysis on datasets generated by next generation sequencing platforms Integrate sequence data with biological experiments/phenotypic data Liaise with collaborators and coordinate projects Train group members Develop software and develop new methods to analyse sequence data [More]
Wellcome Trust Sanger Institute - Biological SciencesSalary: Not specified [More]
PDF Salary range: £30655 to £38428 per annum plus excellent benefits.: Wellcome Trust Sanger Institute: We are looking for a highly motivated Single Cell RNA-seq bioinformatics Postdoctoral Fellows who will develop their career by contributing to our study and joining the Brazma/Marioni/Teichmann groups. Cambridge, Cambridgeshire (GB) [More]