Job Description:
The focus of this position will be to develop high quality, robust and efficient bioinformatics workflows for analyzing amplicon and vector sequencing data for the characterization of CRISPR-engineered mouse and cell line models and gene therapy vectors (e.g., AAV). Specifically, several bioinformatics tools and scripts will be integrated into a single framework which will allow scientists in the Next Generation Sequencing lab and CSB team to quickly turn around amplicon sequencing results to the biologists, including informative data visualizations and QC metrics. This framework will also be integrated seamlessly into existing NGS analysis pipeline infrastructure. Specific duties include: • Design amplicon DNA sequencing bioinformatics workflows in Python and collaborate with Biogen scientists to apply these pipelines to CRISPR mutatgenesis studies. • Produce well written study reports leveraging clear data visualization techniques Location: Cambridge, MA, US Job Category: Research
Additional Info:
About Biogen Corporate Overview Through cutting-edge science and medicine, Biogen discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Biogen is a pioneer in biotechnology and today the Company has the leading portfolio of medicines to treat multiple sclerosis (MS), has introduced the first and only approved treatment for spinal muscular atrophy, and is at the forefront of neurology research for conditions including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Biogen also manufactures and commercializes biosimilars of advanced biologics. Our global organization of nearly 7,000 employees is committed to a single mission: making a meaningful difference in the lives of patients with few or no treatment options. One of the pioneers in biotechnology, Biogen was founded in 1978 and today serves patients in nearly 90 countries. Our global headquarters and R&D operations are located in Cambridge, Massachusetts, with an international headquarters in Zug, Switzerland, world-class manufacturing facilities in Research Triangle Park, North Carolina, USA and Hillerod, Denmark, and affiliate locations around the world. Our Science We aspire to have the greatest impact on patients and science of any biotechnology company in the history of our industry. To us, that means creating novel medicines that benefit individuals and society, and bringing new scientific understanding to diseases for which there are no adequate treatments. For nearly two decades Biogen has led in the research and development of new therapies to treat MS, including the most prescribed oral treatment in the world. Now our research is driving revolutionary new MS treatments with the goal of reversing or even repairing damage caused by the disease. We are now applying our neurological expertise to solve some of most challenging and complex diseases of the brain, including Alzheimer’s disease, Parkinson’s disease, and ALS. As we uncover new insights into human biology, Biogen is employing cutting-edge technologies to discover potential treatments for rare and genetic disorders. Biogen is revolutionizing biologics manufacturing, developing the industry’s most advanced plants and processes. This expertise is used to produce both original innovative therapies and biosimilars that expand patient access to lower-cost medicines. Our Corporate Citizenship The same intellectual discipline and passion that drives our science is reflected in our corporate citizenship, environmental sustainability, and commitment to diversity and inclusion. As a company, we are focused on improving science education and limiting the impact of our company on the environment. In 2015, we became a carbon neutral company and ranked first place on Newsweek’s 2015 Green Rankings, and we are an industry leader on the Dow Jones Sustainability World Index. Biogen was named to Science’s list of Top Employers of 2015 and in 2017 received a perfect score of 100 for the fourth consecutive year on the Human Rights Campaign (HRC) Corporate Equality Index, which also named Biogen as one of its Best Places to Work. All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States. Please be advised that all legitimate correspondence from a Biogen employee will come from "@biogen.com" email accounts.[Click Here to Access the Original Job Post]
The focus of this position will be to develop high quality, robust and efficient bioinformatics workflows for analyzing amplicon and vector sequencing data for the characterization of CRISPR-engineered mouse and cell line models and gene therapy vectors (e.g., AAV). Specifically, several bioinformatics tools and scripts will be integrated into a single framework which will allow scientists in the Next Generation Sequencing lab and CSB team to quickly turn around amplicon sequencing results to the biologists, including informative data visualizations and QC metrics. This framework will also be integrated seamlessly into existing NGS analysis pipeline infrastructure. Specific duties include: • Design amplicon DNA sequencing bioinformatics workflows in Python and collaborate with Biogen scientists to apply these pipelines to CRISPR mutatgenesis studies. • Produce well written study reports leveraging clear data visualization techniques Location: Cambridge, MA, US Job Category: Research
Qualifications
Required: • Solid foundation in computational biology principles • Solid experience in using various scripting languages (e.g., Perl, Python, shell scripting) • Experience processing and analyzing large genomic datasets, especially RNA-Seq • Understanding of statistics concepts including ANOVA, multiple measures, regression and linear models • Experience in statistical analysis programs (e.g., R, Matlab) • Excellent written and oral communication skills Desirable: • Experience with a variety of NGS protocols (e.g. WGS, WES, RNA-seq, ChIP-seq, ATAC-seq) • Experience creating databases e.g., using MySQL, Oracle, or MongoDB • Experience developing novel scientific data visualizations, e.g., using R Shiny • Demonstrated ability to work successfully in cross-functional teams (bioinformatics, biologists, IT) • Ability to learn and adapt quickly to new projects/areas that have not worked on previously (i.e. dealing with new NGS assays) • Experience in a Linux environment and HPC environment (e.g. SGE)Education
Required: B.S. in Bioinformatics, Computational Biology, Computer Science, Genetics, Mathematics/Statistics, Engineering, or a related field or discipline with an emphasis on genomics and bioinformatics.Requeriments :
Skills :
- Bioinformatics
- Computational Biology
- Database design
- DNA sequencing
- genomic
- HPC
- Lunix/Unix
- MongoDB
- MySQL
- Next Generation Sequencing
- Programing in Python
- Programming in Matlab
- Programming in PERL
- Programming in R
- RNA-seq
- Shell scripting
- Statistics
Areas :
Additional Info:
About Biogen Corporate Overview Through cutting-edge science and medicine, Biogen discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Biogen is a pioneer in biotechnology and today the Company has the leading portfolio of medicines to treat multiple sclerosis (MS), has introduced the first and only approved treatment for spinal muscular atrophy, and is at the forefront of neurology research for conditions including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Biogen also manufactures and commercializes biosimilars of advanced biologics. Our global organization of nearly 7,000 employees is committed to a single mission: making a meaningful difference in the lives of patients with few or no treatment options. One of the pioneers in biotechnology, Biogen was founded in 1978 and today serves patients in nearly 90 countries. Our global headquarters and R&D operations are located in Cambridge, Massachusetts, with an international headquarters in Zug, Switzerland, world-class manufacturing facilities in Research Triangle Park, North Carolina, USA and Hillerod, Denmark, and affiliate locations around the world. Our Science We aspire to have the greatest impact on patients and science of any biotechnology company in the history of our industry. To us, that means creating novel medicines that benefit individuals and society, and bringing new scientific understanding to diseases for which there are no adequate treatments. For nearly two decades Biogen has led in the research and development of new therapies to treat MS, including the most prescribed oral treatment in the world. Now our research is driving revolutionary new MS treatments with the goal of reversing or even repairing damage caused by the disease. We are now applying our neurological expertise to solve some of most challenging and complex diseases of the brain, including Alzheimer’s disease, Parkinson’s disease, and ALS. As we uncover new insights into human biology, Biogen is employing cutting-edge technologies to discover potential treatments for rare and genetic disorders. Biogen is revolutionizing biologics manufacturing, developing the industry’s most advanced plants and processes. This expertise is used to produce both original innovative therapies and biosimilars that expand patient access to lower-cost medicines. Our Corporate Citizenship The same intellectual discipline and passion that drives our science is reflected in our corporate citizenship, environmental sustainability, and commitment to diversity and inclusion. As a company, we are focused on improving science education and limiting the impact of our company on the environment. In 2015, we became a carbon neutral company and ranked first place on Newsweek’s 2015 Green Rankings, and we are an industry leader on the Dow Jones Sustainability World Index. Biogen was named to Science’s list of Top Employers of 2015 and in 2017 received a perfect score of 100 for the fourth consecutive year on the Human Rights Campaign (HRC) Corporate Equality Index, which also named Biogen as one of its Best Places to Work. All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States. Please be advised that all legitimate correspondence from a Biogen employee will come from "@biogen.com" email accounts.[Click Here to Access the Original Job Post]