Job Description:
Are you an adaptable bioinformatics analyst who can address some of the demands of technology development, algorithm prototyping and supporting production code development? Are you excited about working with a group of scientists and engineers to harness the promises of next-generation sequencing technology to create unprecedented diagnostics in oncology? Do you have a strong desire to craft code that helps clinicians to accurately identify cancer specific aberrations from next-generation sequencing technologies? Responsibilities:
Additional Info:
Roche is the world leader in in-vitro diagnostics (IVD) and tissue-based cancer diagnostics and a front-runner in diabetes management. Roche Sequencing Solutions is seeking a talented Bioinformatics scientist to collaborate with experimentalists on new assay optimization and to build the underlying analysis algorithms to support end-to-end diagnostics solutions. Who we are: At Roche, 91,700 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law. If you have a disability and need an accommodation in connection with the on-line application process, please email us at US.Accommodation@roche.com. EEO is the Law PAY TRANSPARENCY NONDISCRIMINATION PROVISION The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)[Click Here to Access the Original Job Post]
Are you an adaptable bioinformatics analyst who can address some of the demands of technology development, algorithm prototyping and supporting production code development? Are you excited about working with a group of scientists and engineers to harness the promises of next-generation sequencing technology to create unprecedented diagnostics in oncology? Do you have a strong desire to craft code that helps clinicians to accurately identify cancer specific aberrations from next-generation sequencing technologies? Responsibilities:
- Develop and refine variant detection algorithms to analyze ultra-deep NGS data for oncology diagnostic applications through statistical modeling of error distributions and experimental covariates, empirical benchmarking, optimization and comparison of algorithmic approaches.
- Analyze and interpret clinical data including extensive data QC, variant call filtering and predictors of clinical endpoints to demonstrate the clinical utility of oncology products, and validate bioinformatics pipelines with real world samples.
- Work closely with experimentalists to develop analysis tools and automation that will aid in optimization of NGS library preparation protocols. Perform statistical meta-analyses of sources of variation affecting assay performance.
- Work with software teams to optimize and translate research software into production standard, including documentation, testing frameworks and modular design.
- Communicate results of bioinformatics analyses to bioinformatics groups, experimental groups, and cross-site collaborators.
- Ph.D. in biostatistics, bioinformatics, computer science, computational biology, or a related discipline.
- Knowledge of applied statistics and probability in the context of analyzing biological data is required.
- Previous analysis experience with short read NGS data, including standard pipelines (eg bwa, samtools, GATK, Varscan etc.), variant detection algorithms, variant annotation and QC metrics.
- Proficiency in a high level scripting language (e.g. Python, R, Perl) required
- Experience with leading projects in a technical role, including setting goals and timelines is desirable.
- Must be comfortable with aggressive timelines and making critical decisions in a rapidly changing environment.
- Experience with oncology projects is desirable.
Requeriments :
Skills :
Areas :
Additional Info:
Roche is the world leader in in-vitro diagnostics (IVD) and tissue-based cancer diagnostics and a front-runner in diabetes management. Roche Sequencing Solutions is seeking a talented Bioinformatics scientist to collaborate with experimentalists on new assay optimization and to build the underlying analysis algorithms to support end-to-end diagnostics solutions. Who we are: At Roche, 91,700 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law. If you have a disability and need an accommodation in connection with the on-line application process, please email us at US.Accommodation@roche.com. EEO is the Law PAY TRANSPARENCY NONDISCRIMINATION PROVISION The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)[Click Here to Access the Original Job Post]