R&D Scientist Bioinformatics – Biopharmaceutics

Job ID: 08737333
Job date: 2017-01-24
End Date:

Company : CMAST 

Country :

Role : Postdoc 


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Job Description:
For the location in Europe (Belgium, Beerse) our client is looking for a Postdoctoral Scientist in Bioinformatics / Biopharmaceutics to play an exciting role in Pharmaceutical Sciences.

As a Postdoctoral Scientist, your overall mission is to design, validate and implement automated high-output in silico and in vitro workflows in the R&D biopharmaceutical platform. You will focus on scientific innovations to strengthen our knowledge of the biopharmaceutical properties of the drug substance and drug product, ensuring optimal in vivo performance.

-Implementation of automated high-output in silico and in vitro workflows in the R&D biopharmaceutical platform to understand the in-vitro in-vivo correlation of absorption parameters and connect pharmaceutical quality attributes with clinical performance.

-Design and coordinate experimental work related to Biopharmaceutics and Physiology Based Pharmacokinetic (PBPK) modeling in support of drug product development.

-Participate in the evaluation of new analytical techniques in the area of biorelevant testing.

-Build and maintain strong relationship with key stakeholders including Discovery Sciences, Clinical Pharmacology, -Drug Product Development and Analytical Development.

-Work in a multidisciplinary team of researchers, internally as well as externally.

-Keep up to date with scientific innovations.

Applicant profile:

-Doctorate (Ph.D.) in Bioinformatics, Cheminformatics, Pharmaceutical Sciences, Biology, Engineering or related science with relevant experience in biopharmaceutics.

-Relevant hands on experience with PBPK modelling (Gastroplus/Simcyp) and in vitro biopharmaceutics (e.g. solubility, biorelevant dissolution, particle characterization, solid state characteristics…).

-Knowledge of and strong interest in API physico-chemistry, drug absorption principles, formulation optimization, pharmacokinetics, and mechanistic design.

-Knowledge of and strong interest in programming languages (R…) or mathematical modeling languages (Matlab).

-Highly motivated, with excellent organizational, interpersonal, communication, and collaborative skills.

-Fluent English & Dutch (both spoken and written) with excellent scientific writing skills.

-Team player, dynamic, stress resistant, innovative and flexible.


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