Job Description:
Performs computational research in the Division of Epigenetics and Transcriptional Engineering in the Department of Systems Biology. Works on a variety of computational biology and genomics projects centered on therapeutic target identification. Will work on internal and external datasets, including next generation bulk and single cell sequencing data, high-throughput genetic screen data, and protein/compound interaction data, etc. Will develop algorithms and analysis strategies to generate focused hypotheses for target identification/validation. Involves in data interpretation and report. A critical component of the job will be the close collaboration with a team of investigators and scientists in biomedical research. Position Accountabilities: The following are essential job accountabilities: 1. Research: Establish the computational research program in the Division and the Department, including the design, analysis, review, summary, interpretation and report of the computational research. Collaborate in a team setting to develop platforms for bioinformatics and biostatistics data analyses. Apply or develop new algorithms/data-mining techniques for integrative analysis and visualization of multi-dimensional data-sets for target discovery. Integrate genomic and experimental data using appropriate statistical methods to facilitate therapeutic target discoveries. Contribute to new ideas, actively engage in scientific discussion, provide expertise to inform discussion of new concepts. Contribute to scientific writing including manuscripts and grant applications. Review scientific manuscripts and grant applications. Contribute to quality controls, verification of scientific results, rigor and robustness of scientific data. Mentoring junior members of the Department including post-doctoral fellows and technologists as relevant for computational research activities. Develop and maintain expertise in a suite of computational biology and biostatistics. 2. Maintains professional growth and development through seminars, workshops, and professional affiliations to maintain certification/licensure, and/or keep abreast of latest trends in field of expertise. 3. Attends departmental meetings as required and participates in the department continuing education program. 4. Follows established City of Hope and department policies, procedures, objectives, performance improvement, attendance, safety, environmental, and infection control guidelines, including adherence to the workplace Code of Conduct and Compliance Plan. Practices a high level of integrity and honesty in maintaining confidentiality. 5. Performs other related duties as assigned or requested. Position Qualifications: Minimum Education: Ph.D. degree in Biology, Bioinformatics or equivalent Minimum Experience: Five years of relevant work experience in bioinformatics or computational biology Req. Certification/Licensure: None Experience: Other Solid understanding of bioinformatics databases and software. Good understanding of biological processes, such as oncology, genetics, and pharmacology. Extensive experiences in sequencing-based data analysis, pipeline development and quality control (such as RNA-seq, ChIP-seq, ATAC-seq, RRBS). Proficient in writing programs for data analysis using R, Unix, Python, etc. Experienced in bioinformatics tools including IGV/UCSC Genome Browser, TCGA, Samtools, Bedtools, DAVID, Tophat, BWA, HTseq, RSeQC, GATK, Picard, cellranger, PARTEK, IPA, CLCBIO, etc. Preferred Field of Expertise: Bioinformatics Skills: Other Excellent trouble-shooting ability. Work independently. Foster and promote a positive image and professional appearance. Aptitude: Req./Pref. -Answer telephones -Maintain logs -Research information -Alpha-Numeric filing -Delegate tasks -Compile data -Prepare reports -Coordinate requests -Instruct/train others -Calculate statistical data Software -Microsoft Office Professional, preferred -R, Unix, Python, required -IGV/UCSC Genome Browser, TCGA, Samtools, Bedtools, DAVID, Tophat, BWA, HTseq, RSeQC, GATK, Picard, cellranger, PARTEK, IPA, CLCBIO, preferred Machines/Equip: Req./Pref. -Calculator -Personal computer -High Perfomance Computation -Computer peripheral equipment Working / Environmental Conditions -Atmosphere and environment associated with an office -Tobacco-free campus -Occasionally subjected to irregular hours -Occasional pressure due to timeline requirements Req. Protective Equipment: NONE Physical Demands: -Moderate physical effort (lift/carry up to 25 lbs.) -Occasional prolonged standing/walking -Occasionally lifts supplies/equipment -Manual dexterity and mobility -Occasional reaching, stooping, bending, kneeling, crouching -Depth Perception: ability to judge distance and space relationships -Accommodation: ability to adjust vision to bring objects into focus -Color Vision: ability to distinguish and identify different colors -Works at tasks involving focused concentration Communication: Excellent oral/written communication and organizational skills
Additional Info:
About City of Hope City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment. Location: Beckman Research Inst – Duarte (Duarte, CA) Shift: Days Schedule Type: Full-Time City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability. [Click Here to Access the Original Job Post]
Performs computational research in the Division of Epigenetics and Transcriptional Engineering in the Department of Systems Biology. Works on a variety of computational biology and genomics projects centered on therapeutic target identification. Will work on internal and external datasets, including next generation bulk and single cell sequencing data, high-throughput genetic screen data, and protein/compound interaction data, etc. Will develop algorithms and analysis strategies to generate focused hypotheses for target identification/validation. Involves in data interpretation and report. A critical component of the job will be the close collaboration with a team of investigators and scientists in biomedical research. Position Accountabilities: The following are essential job accountabilities: 1. Research: Establish the computational research program in the Division and the Department, including the design, analysis, review, summary, interpretation and report of the computational research. Collaborate in a team setting to develop platforms for bioinformatics and biostatistics data analyses. Apply or develop new algorithms/data-mining techniques for integrative analysis and visualization of multi-dimensional data-sets for target discovery. Integrate genomic and experimental data using appropriate statistical methods to facilitate therapeutic target discoveries. Contribute to new ideas, actively engage in scientific discussion, provide expertise to inform discussion of new concepts. Contribute to scientific writing including manuscripts and grant applications. Review scientific manuscripts and grant applications. Contribute to quality controls, verification of scientific results, rigor and robustness of scientific data. Mentoring junior members of the Department including post-doctoral fellows and technologists as relevant for computational research activities. Develop and maintain expertise in a suite of computational biology and biostatistics. 2. Maintains professional growth and development through seminars, workshops, and professional affiliations to maintain certification/licensure, and/or keep abreast of latest trends in field of expertise. 3. Attends departmental meetings as required and participates in the department continuing education program. 4. Follows established City of Hope and department policies, procedures, objectives, performance improvement, attendance, safety, environmental, and infection control guidelines, including adherence to the workplace Code of Conduct and Compliance Plan. Practices a high level of integrity and honesty in maintaining confidentiality. 5. Performs other related duties as assigned or requested. Position Qualifications: Minimum Education: Ph.D. degree in Biology, Bioinformatics or equivalent Minimum Experience: Five years of relevant work experience in bioinformatics or computational biology Req. Certification/Licensure: None Experience: Other Solid understanding of bioinformatics databases and software. Good understanding of biological processes, such as oncology, genetics, and pharmacology. Extensive experiences in sequencing-based data analysis, pipeline development and quality control (such as RNA-seq, ChIP-seq, ATAC-seq, RRBS). Proficient in writing programs for data analysis using R, Unix, Python, etc. Experienced in bioinformatics tools including IGV/UCSC Genome Browser, TCGA, Samtools, Bedtools, DAVID, Tophat, BWA, HTseq, RSeQC, GATK, Picard, cellranger, PARTEK, IPA, CLCBIO, etc. Preferred Field of Expertise: Bioinformatics Skills: Other Excellent trouble-shooting ability. Work independently. Foster and promote a positive image and professional appearance. Aptitude: Req./Pref. -Answer telephones -Maintain logs -Research information -Alpha-Numeric filing -Delegate tasks -Compile data -Prepare reports -Coordinate requests -Instruct/train others -Calculate statistical data Software -Microsoft Office Professional, preferred -R, Unix, Python, required -IGV/UCSC Genome Browser, TCGA, Samtools, Bedtools, DAVID, Tophat, BWA, HTseq, RSeQC, GATK, Picard, cellranger, PARTEK, IPA, CLCBIO, preferred Machines/Equip: Req./Pref. -Calculator -Personal computer -High Perfomance Computation -Computer peripheral equipment Working / Environmental Conditions -Atmosphere and environment associated with an office -Tobacco-free campus -Occasionally subjected to irregular hours -Occasional pressure due to timeline requirements Req. Protective Equipment: NONE Physical Demands: -Moderate physical effort (lift/carry up to 25 lbs.) -Occasional prolonged standing/walking -Occasionally lifts supplies/equipment -Manual dexterity and mobility -Occasional reaching, stooping, bending, kneeling, crouching -Depth Perception: ability to judge distance and space relationships -Accommodation: ability to adjust vision to bring objects into focus -Color Vision: ability to distinguish and identify different colors -Works at tasks involving focused concentration Communication: Excellent oral/written communication and organizational skills
Requeriments :
Skills :
- Bioinformatics
- Bioinformatics Databases
- Biology
- Biostatistics
- Computational Biology
- Genetics
- HPC
- Lunix/Unix
- Programing in Python
- Programming in R
- RNA-seq
- Software Design
Areas :
Additional Info:
About City of Hope City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment. Location: Beckman Research Inst – Duarte (Duarte, CA) Shift: Days Schedule Type: Full-Time City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability. [Click Here to Access the Original Job Post]