Job ID: 661056445
Job date: 2018-04-15
End Date:
Company : The Netherlands Cancer Institute Country : Role : Postdoc
Job date: 2018-04-15
End Date:
Company : The Netherlands Cancer Institute Country : Role : Postdoc
Job Description:
The Faller lab at the Division of Oncogenomics is seeking a talented and enthusiastic individual to study the regulation of RNA translation in normal and cancer context. Project: The Faller Lab is focused on understanding the role that altered RNA translation plays in cancer. This project involves the study of RNA translation using sophisticated high-throughput techniques, including RiboSeq and StructureSeq. We are seeking a candidate who can integrate data regarding the translational efficiency and secondary structure of mRNAs, the abundance of tRNAs, the codon usage and RNA motif analysis, in order to understand the contribution these various aspects to the rate of translation in cancer cells. The successful candidate will be responsible for the building of computational models needed to merge and compare these datasets, and build a greater understanding or the role of altered RNA translation in cancer. Your profile: We are seeking a highly motivated Postdoc with training in bioinformatics or computer science, and solid experience in bioinformatics and statistics tools. Applicants should be experienced in cancer biology and clinical applications and should have experience in analysing high-throughput genomic data (e.g. DNA and RNA sequencing). The candidate needs to be proficient in common bioinformatics scripting and programming languages (e.g. R, Python). The position also requires the ability to communicate effectively with scientists from various backgrounds, and a demonstrable capability for independent thinking. A general background in biology is desirable, and fluency in spoken and written English is required. Your career opportunities and terms of employment State-of-the-art facilities The research groups at the NKI-AVL are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenics, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more. Inspiring international atmosphere Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute. Inviting conditions We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, salary scale 55 according to the Collective Labour Agreement General Hospitals, ranging from €3215,- to €3.917,- based on proven qualifications and experience) and housing facilities in the vicinity of the Institute. The appointment is for a period of at least 3 years.
Additional Info:
The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumour models, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer centre, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research. The Netherlands Cancer Institute (Het Nederlands Kanker Instituut, NKI) is an exciting and rewarding place to work. It is an internationally recognized center of scientific excellence in many key areas relating to cancer. The NKI also stands out as the only official Comprehensive Cancer Center in The Netherlands. The combination of a research institute and a dedicated cancer clinic (the Antoni van Leeuwenhoek hospital) under one roof facilitates the translation of basal research to clinical applications. It also ensures that our researchers are aware of the most urgent questions our oncologists come across in the clinic. The NKI was established in October 1913, making it one of the oldest cancer research centers in the world. Nowadays, our research institute accommodates approximately 650 scientists and scientific support personnel. The Antoni van Leeuwenhoek Hospital has 185 medical specialists, 180 beds, an out-patients clinic that receives around 106,000 visits a year, 12 operating theaters and 11 irradiation units for radiotherapy. The many research divisions within our institute focus on fundamental, translational, and clinical research. At the moment, our main research themes are: • Molecular Oncology: how do tumors arise and develop, and how do cancer cells differ from healthy cells? • Cancer Immunology: how does our body’s immune system work, and how can we exploit it to fight cancer? • Precision Medicine: each tumor has its own genetic makeup and characteristics. Which treatment is best for the specific tumor of individual patients? • Image Guided Interventions: how can we further improve imaging during surgery, radiotherapy, or the whole course of the cancer treatment, to better cure patients? • Survivorship: which factors determine the risk of developing cancer and how can we improve the quality of life of (former) cancer patients? [Click Here to Access the Original Job Post]
The Faller lab at the Division of Oncogenomics is seeking a talented and enthusiastic individual to study the regulation of RNA translation in normal and cancer context. Project: The Faller Lab is focused on understanding the role that altered RNA translation plays in cancer. This project involves the study of RNA translation using sophisticated high-throughput techniques, including RiboSeq and StructureSeq. We are seeking a candidate who can integrate data regarding the translational efficiency and secondary structure of mRNAs, the abundance of tRNAs, the codon usage and RNA motif analysis, in order to understand the contribution these various aspects to the rate of translation in cancer cells. The successful candidate will be responsible for the building of computational models needed to merge and compare these datasets, and build a greater understanding or the role of altered RNA translation in cancer. Your profile: We are seeking a highly motivated Postdoc with training in bioinformatics or computer science, and solid experience in bioinformatics and statistics tools. Applicants should be experienced in cancer biology and clinical applications and should have experience in analysing high-throughput genomic data (e.g. DNA and RNA sequencing). The candidate needs to be proficient in common bioinformatics scripting and programming languages (e.g. R, Python). The position also requires the ability to communicate effectively with scientists from various backgrounds, and a demonstrable capability for independent thinking. A general background in biology is desirable, and fluency in spoken and written English is required. Your career opportunities and terms of employment State-of-the-art facilities The research groups at the NKI-AVL are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenics, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more. Inspiring international atmosphere Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute. Inviting conditions We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, salary scale 55 according to the Collective Labour Agreement General Hospitals, ranging from €3215,- to €3.917,- based on proven qualifications and experience) and housing facilities in the vicinity of the Institute. The appointment is for a period of at least 3 years.
Requeriments :
Skills :
- Bioinformatics
- Biology
- Cancer biology
- DNA sequencing
- Programing in Python
- Programing Skills
- Programming in R
- RNA-seq
- Statistics
Areas :
Additional Info:
The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumour models, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer centre, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research. The Netherlands Cancer Institute (Het Nederlands Kanker Instituut, NKI) is an exciting and rewarding place to work. It is an internationally recognized center of scientific excellence in many key areas relating to cancer. The NKI also stands out as the only official Comprehensive Cancer Center in The Netherlands. The combination of a research institute and a dedicated cancer clinic (the Antoni van Leeuwenhoek hospital) under one roof facilitates the translation of basal research to clinical applications. It also ensures that our researchers are aware of the most urgent questions our oncologists come across in the clinic. The NKI was established in October 1913, making it one of the oldest cancer research centers in the world. Nowadays, our research institute accommodates approximately 650 scientists and scientific support personnel. The Antoni van Leeuwenhoek Hospital has 185 medical specialists, 180 beds, an out-patients clinic that receives around 106,000 visits a year, 12 operating theaters and 11 irradiation units for radiotherapy. The many research divisions within our institute focus on fundamental, translational, and clinical research. At the moment, our main research themes are: • Molecular Oncology: how do tumors arise and develop, and how do cancer cells differ from healthy cells? • Cancer Immunology: how does our body’s immune system work, and how can we exploit it to fight cancer? • Precision Medicine: each tumor has its own genetic makeup and characteristics. Which treatment is best for the specific tumor of individual patients? • Image Guided Interventions: how can we further improve imaging during surgery, radiotherapy, or the whole course of the cancer treatment, to better cure patients? • Survivorship: which factors determine the risk of developing cancer and how can we improve the quality of life of (former) cancer patients? [Click Here to Access the Original Job Post]