Job ID: QMUL15068
Job date: 2018-06-01
End Date: 2018-06-22
Company : Queen Mary University of London Country : United Kingdom Role : Other
Job date: 2018-06-01
End Date: 2018-06-22
Company : Queen Mary University of London Country : United Kingdom Role : Other
Job Description:
Applications are sought for a talented Bioinformatician to join a highly-collaborative bioinformatics team to study and characterise functional noncoding mutations in cancer, funded by Academy of Medical Sciences Springboard Award for two years. We will be using follicular lymphoma as our study model, thanks to the strong clinical and research programs in lymphoma at Barts. Our work will include: first, to develop and improve our existing analytical pipelines for next-generation sequencing (NGS) data analysis, especially for ChIP-seq variant calling and RNA-seq allele-specific expression; second, to assemble relevant publicly available data sets to be used for the downstream data analysis and integration; third, to analyse the assembled data sets together with in-house generated data to identify and prioritise functional noncoding mutations and variants that affect gene regulation and have the tumourigenic potential. The significantly mutated regulatory elements and mutations will be further validated in an independent patient cohort, with the top candidates further functionally validated in the lab. This post will be leading this project and responsible for the computational elements of this project. In addition, the post holder is required to communicate and work well with web-lab collaborators to ensure the best outcome of this project. The post will be based in the Centre for Molecular Oncology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Essential requirements for this post include a PhD in Bioinformatics and Computational Biology or a relevant discipline. In exceptional circumstances, a candidate without a PhD but with extensive experience may be considered. Candidates must demonstrate knowledge and experience in large-scale data analysis, especially next-generation sequencing data sets. Experience in data integration and modeling is desirable. Knowledge in cancer genetics and genomics will be much appreciated. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential. The post is full time for 24 months starting from 1st July 2018 or as soon as possible thereafter). Starting salary will be in the range £32,956 to £34,764 per annum (if part-time – pro rata) inclusive of London Allowance. Benefits include 30 days’ annual leave (if part-time – pro rata), defined benefit pension scheme and interest-free season ticket loan.
Additional Info:
Location: London Salary: £32,956 to £34,764 Hours: Full Time Contract Type: Fixed-Term/Contract Placed on: 31st May 2018 Closes: 22nd June 2018 Job Ref: QMUL15068 The Barts Cancer Institute requires applicants to provide all certificates at interview to confirm their qualifications (specified in the Job Description). Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme. Informal enquiries should be addressed to Dr Jun Wang, j.a.wang@qmul.ac.uk Details about Barts Cancer Institute can be found at www.bci.qmul.ac.uk To apply and for full job details including a job description and person specification please visit http://www.hr.qmul.ac.uk/jobs/ and search for reference QMUL15068 Application enquiries can be directed to recruitment@qmul.ac.uk The closing date for all applications is: 22 June 2018 Interviews are expected to take place shortly afterwards.[Click Here to Access the Original Job Post]
Applications are sought for a talented Bioinformatician to join a highly-collaborative bioinformatics team to study and characterise functional noncoding mutations in cancer, funded by Academy of Medical Sciences Springboard Award for two years. We will be using follicular lymphoma as our study model, thanks to the strong clinical and research programs in lymphoma at Barts. Our work will include: first, to develop and improve our existing analytical pipelines for next-generation sequencing (NGS) data analysis, especially for ChIP-seq variant calling and RNA-seq allele-specific expression; second, to assemble relevant publicly available data sets to be used for the downstream data analysis and integration; third, to analyse the assembled data sets together with in-house generated data to identify and prioritise functional noncoding mutations and variants that affect gene regulation and have the tumourigenic potential. The significantly mutated regulatory elements and mutations will be further validated in an independent patient cohort, with the top candidates further functionally validated in the lab. This post will be leading this project and responsible for the computational elements of this project. In addition, the post holder is required to communicate and work well with web-lab collaborators to ensure the best outcome of this project. The post will be based in the Centre for Molecular Oncology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Essential requirements for this post include a PhD in Bioinformatics and Computational Biology or a relevant discipline. In exceptional circumstances, a candidate without a PhD but with extensive experience may be considered. Candidates must demonstrate knowledge and experience in large-scale data analysis, especially next-generation sequencing data sets. Experience in data integration and modeling is desirable. Knowledge in cancer genetics and genomics will be much appreciated. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential. The post is full time for 24 months starting from 1st July 2018 or as soon as possible thereafter). Starting salary will be in the range £32,956 to £34,764 per annum (if part-time – pro rata) inclusive of London Allowance. Benefits include 30 days’ annual leave (if part-time – pro rata), defined benefit pension scheme and interest-free season ticket loan.
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Additional Info:
Location: London Salary: £32,956 to £34,764 Hours: Full Time Contract Type: Fixed-Term/Contract Placed on: 31st May 2018 Closes: 22nd June 2018 Job Ref: QMUL15068 The Barts Cancer Institute requires applicants to provide all certificates at interview to confirm their qualifications (specified in the Job Description). Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme. Informal enquiries should be addressed to Dr Jun Wang, j.a.wang@qmul.ac.uk Details about Barts Cancer Institute can be found at www.bci.qmul.ac.uk To apply and for full job details including a job description and person specification please visit http://www.hr.qmul.ac.uk/jobs/ and search for reference QMUL15068 Application enquiries can be directed to recruitment@qmul.ac.uk The closing date for all applications is: 22 June 2018 Interviews are expected to take place shortly afterwards.[Click Here to Access the Original Job Post]