Bioinformatics Programmer II – Molecular and Human Genetics

Job ID: 176393515
Job date: 2016-12-16
End Date:

Company : Baylor College of Medicine 

Country :

Role : Research Scientist 


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Job Description:
A research lab in the Department of Molecular and Human Genetics at Baylor College of Medicine is looking to hire a Bioinformatics Programmer with prior experience in analysis of Next Generation Sequencing Datasets from Exome, Whole Genome and RNA Sequencing experiments. This lab primarily utilizes data from Exome and Whole Genome sequencing experiments to identify SNPs, Indels, Copy Number variants and other genomic aberrations followed by mitochondrial functional profiling in patient cells to identify validated novel mitochondrial disease genes implicated in childhood-onset mitochondrial disorders. For more information on the lab and previous publications: https://www.bcm.edu/people/view/b23150a1-ffed-11e2-be68-080027880ca6

Maintain the existing Exome, Whole Genome and RNA Seq variant analysis pipelines and continually identify novel tools and annotation databases to improve the efficiency, sensitivity and functionality of the results Identify bioinformatics tools or develop, thoroughly test and deploy novel software in the absence of an existing alternative and automate workflows for various routine bioinformatics analysis tasks Provide high quality data analysis, generate publication quality reports and plots for a diverse variety of bioinformatics challenges while working with collaborators from diverse scientific research and clinical backgrounds.

Identify new analysis methods and suggest informatics solutions for various biological problems within the lab Required: Bachelor's degree in Computer Science or Biological Sciences. Master's preferred.

Required: Two years of experience in scientific programming with applications to biomedical research, preferably in the area of genomics and next generation sequencing analysis

Required: Experience with Perl, HTML, CGI, relation databases and SQL. Programming in a UNIX/LINUX environment.

Preferred: Experience with C++ and programming using UNIX/LINUX clusters.

Thorough understanding of bioinformatics concepts such as sequence alignment, duplication removal, sequence retrieval, variant calling, gene and functional annotation, isoform and gene expression is essential to succeed in this role.

Excellent programming skill in at least one scripting language such as Perl (preferred), Python or Ruby is required, programming knowledge in at least one of Java, C, C++, knowledge of SQL is useful 5. Must maintain well documented tested code and thoroughly document analysis results.

Ability to perform data wrangling, statistical analysis and plotting in R is essential

Must be comfortable working in a Unix/Linux operating system and knowledge of command line tools is essential

Strong knowledge of commonly used bioinformatics packages such as the Genome Analysis Tool Kit (GATK), BWA, Bowtie, SAMtools, Picard, IGV, Tophat, Cufflinks, Annovar, BEDtools etc and ability to apply them to regular Bioinformatics problems is necessary

Knowledge of working with a high performance computing (HPC) cluster such as LSF, Sun Grid Engine (SGE) or MOAB is useful

Familiarity with biological data repositories such as the UCSC Genome Browser, NCBI, 1000 genomes, dbNSFP, Exome Aggregation Consortium (ExAC), BioMart etc and their associated APIs to retrieve data is essential

Baylor College of Medicine is a highly collaborative work environment and as such strong communication skills and ability to interact with other researchers from diverse scientific backgrounds is mandatory

Ability to multi task while working independently and exercising good judgment in terms of meeting deadlines is essential

Must be motivated to learn new technologies and contribute towards publications in peer reviewed journals


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Additional Info:
Posting Number: 269529KP

BCM Department: Molecular and Human Genetics

Subsection:

Location: BCM Main Campus, Houston

Salary Range: $46,920 - $62,000

Employment Duration: Full-time

Staff Job Category: Bioinformatics, Hot Job, Information Technology

Application Documents: The following is a list of the Required and Optional documents for this position. Please be sure to have them ready before you submit your application.

Required Documents: Resume/CV

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