Job ID: 597967738
Job date: 2018-03-22
End Date:
Company : Personalis Country : Role : Research Scientist
Job date: 2018-03-22
End Date:
Company : Personalis Country : Role : Research Scientist
Job Description:
You will work with a world-class, dynamic team of bioinformatics scientists, software engineers, laboratory scientists, assay developers, product managers, and clinicians applying our cutting-edge cancer and immuno-oncology solutions to plan, manage, analyze, and interpret impactful collaborative R&D projects. You will be part of a team focused on development of the latest methods for analyzing genomics data, building analysis pipelines and algorithms, and validating tools for immuno-oncology, neoantigens, and cancer. Your work will contribute to a new generation of genomics based precision medicine products in immuno-oncology and cancer clinical trials, diagnostics, and therapeutics being used by pharma, biotech, hospitals and clinicians. Responsibilities:
Additional Info:
Personalis, Inc. is a dynamic venture-backed company founded out of Stanford pioneering precision medicine by developing, cutting-edge NGS genomic solutions for immuno-oncology, cancer, and inherited disease. Based in Menlo Park, CA, Personalis' patented ACE platform (Accuracy and Content Enhanced) provides an integrated, innovative, high accuracy technological solution from NGS sequencing to interpretation for precision medicine applications. The ACE Platform forms the technological basis for enabling Personalis' leading products for immuno-oncology, cancer diagnostics, and inherited disease. Personalis is an equal opportunity employer. Personalis offers a competitive compensation package. Personalis is a genome-scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically-focused conclusions from these. Our tests are based on whole human genome, exome sequencing, and gene panel sequencing conducted in our state-of-the art CLIA/CAP certified laboratory. We analyze and report results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms. Personalis is an equal opportunity employer. Personalis offers a competitive compensation package. If interested, please submit a letter of interest, resume and salary requirements to careers@personalis.com Apply for this Position [Click Here to Access the Original Job Post]
You will work with a world-class, dynamic team of bioinformatics scientists, software engineers, laboratory scientists, assay developers, product managers, and clinicians applying our cutting-edge cancer and immuno-oncology solutions to plan, manage, analyze, and interpret impactful collaborative R&D projects. You will be part of a team focused on development of the latest methods for analyzing genomics data, building analysis pipelines and algorithms, and validating tools for immuno-oncology, neoantigens, and cancer. Your work will contribute to a new generation of genomics based precision medicine products in immuno-oncology and cancer clinical trials, diagnostics, and therapeutics being used by pharma, biotech, hospitals and clinicians. Responsibilities:
- Develop components of innovative cancer and immuno-oncology products, focusing on detection of cell free variants
- Develop methods for genomics based characterization of immuno-modulators and biomarkers for immuno-therapy
- Develop methods for monitoring the tumor microenvironment.
- Extrapolate collaborative findings, identifying new product applications, new product opportunities, and biomarkers for cancer treatment that will influence product development
- Work cross-functionally to translate collaborative findings into actively developed cutting-edge products
- Design and develop tools for high accuracy, comprehensive somatic variant detection from DNA and RNA sequencing
- Design and implement validation strategies for both newly developed and existing genomics analysis tools and pipelines
- Publish results and present at conferences in the area of cancer and immuno-oncology
- Advanced degree (PhD) in bioinformatics, genomics, or a related field
- Extensive experience with genomic analysis of NGS based cell free DNA or RNA assays
- Extensive experience in cancer genomics especially in immuno-oncology
- Experience developing bioinformatics pipelines and tools for NGS
- Knowledge of neoantigens, immune checkpoints, tumor microenvironment, and tumor escape mechanisms.
- Experience with biostatistics and study design
- Experience with cancer genomics software: Mutect, Varscan2, etc.
- Experience of cancer variant detection – Small variants, fusions, CNAs, etc.
- Experience with standard genomics software: BWA, GATK, SAMTools, etc
- Familiarity with cancer databases: Cosmic, TCGA, etc.
- Familiarity with different assays, modes of sequencing, and analysis approaches (WGS vs. Exome, RNA-seq)
- Fluency in at least one common programming language (e.g., Python, R)
- Experience with BASH scripting and Unix/Linux command line tools
- Familiarity with version control systems, preferably Git a plus
- Familiarity with grid computing systems such as SGE a plus.
Requeriments :
Skills :
- Biostatistics
- Cancer Genomics
- DNA sequencing
- genomic
- Lunix/Unix
- Next Generation Sequencing
- Programing in Python
- Programing Skills
- Programming in R
- RNA-seq
- Version Control
Areas :
Additional Info:
Personalis, Inc. is a dynamic venture-backed company founded out of Stanford pioneering precision medicine by developing, cutting-edge NGS genomic solutions for immuno-oncology, cancer, and inherited disease. Based in Menlo Park, CA, Personalis' patented ACE platform (Accuracy and Content Enhanced) provides an integrated, innovative, high accuracy technological solution from NGS sequencing to interpretation for precision medicine applications. The ACE Platform forms the technological basis for enabling Personalis' leading products for immuno-oncology, cancer diagnostics, and inherited disease. Personalis is an equal opportunity employer. Personalis offers a competitive compensation package. Personalis is a genome-scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically-focused conclusions from these. Our tests are based on whole human genome, exome sequencing, and gene panel sequencing conducted in our state-of-the art CLIA/CAP certified laboratory. We analyze and report results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms. Personalis is an equal opportunity employer. Personalis offers a competitive compensation package. If interested, please submit a letter of interest, resume and salary requirements to careers@personalis.com Apply for this Position [Click Here to Access the Original Job Post]