Job Description:
PROFILE : employs state-of-the art genomics technology to generate a detailed report of medically actionable genetic alterations in a CLIA-certified and real-time process to facilitate rapid clinical application. These cancer genomic profiles are being used to guide patient treatment and/or stratification for clinical trials of novel anticancer agents. Working under very general supervision, the Computational Bioinformatician I will have demonstrated competency is one of more of the following areas of specialization: algorithm development, data analysis,quality assurance/testing, pipeline software/computing development, user interface design & report development, web-based application development, Laboratory Information Management System (LIMS) development, or report development, as described below. JOB SPECIFIC DUTIES AND RESPONSIBILITIES: BIOINFORMATICS ANALYST The Bioinformatics Analyst will help develop, maintain, and refine the team’s bioinformatics capabilities for genome research in cancer. This exciting opportunity will offer the candidate the chance to analyze data from both germline and cancer samples using a variety of NGS endpoints. Additionally, this is an opportunity for the analyst to work with a truly unique dataset: The Profile: project at DFCI/BWH contains genomic and clinical information for over 20,000 patients. The bioinformatics analyst will have the opportunity to work with DFCI and BWH scientists to mine this data for new insights into cancer. Additional duties may include, but are not limited to:
Additional Info:
The Center for Advanced Molecular Diagnostics (CAMD) is the clinical molecular diagnostics laboratory for three Harvard Medical School hospitals: Brigham and Women's Hospital, Dana-Farber Cancer Institute, and for the pediatric cancer patients of Boston Children's Hospital. Our mission is to provide innovative molecular and cytogenetic diagnostic services to assist with the clinical care of patients in our hospitals and affiliated clinics, with a primary focus on cancer care. Primary Location : MA-Boston-Boston - BWH Main Campus Work Locations : Boston - BWH Main Campus 75 Francis St Boston 02115 Job : Biomedical Organization: Brigham & Women's Hospital(BWH) Schedule : Full-time Standard Hours : 40 Shift : Day Job Employee Status : Regular Recruiting Department : BWH Pathology [Click Here to Access the Original Job Post]
PROFILE : employs state-of-the art genomics technology to generate a detailed report of medically actionable genetic alterations in a CLIA-certified and real-time process to facilitate rapid clinical application. These cancer genomic profiles are being used to guide patient treatment and/or stratification for clinical trials of novel anticancer agents. Working under very general supervision, the Computational Bioinformatician I will have demonstrated competency is one of more of the following areas of specialization: algorithm development, data analysis,quality assurance/testing, pipeline software/computing development, user interface design & report development, web-based application development, Laboratory Information Management System (LIMS) development, or report development, as described below. JOB SPECIFIC DUTIES AND RESPONSIBILITIES: BIOINFORMATICS ANALYST The Bioinformatics Analyst will help develop, maintain, and refine the team’s bioinformatics capabilities for genome research in cancer. This exciting opportunity will offer the candidate the chance to analyze data from both germline and cancer samples using a variety of NGS endpoints. Additionally, this is an opportunity for the analyst to work with a truly unique dataset: The Profile: project at DFCI/BWH contains genomic and clinical information for over 20,000 patients. The bioinformatics analyst will have the opportunity to work with DFCI and BWH scientists to mine this data for new insights into cancer. Additional duties may include, but are not limited to:
- Identify opportunities and develop innovative solutions for the analysis, integration, and representation of data from multiple NGS endpoints.
- Evaluation of external and internally developed tools for analyzing NGS data
- Assist in developing methods for variant filtration and annotation
- Provide direct technical and scientific support for CCGD & Profile investigators and staff
Qualifications
JOB SPECIFIC SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:- Bachelor’s degree in bioinformatics, computer science, statistics, and/or the life sciences and 2+ years relevant experience. Advanced degree preferred. Previous experience in molecular biology, cancer genomics, or a related field is required.
- Experience in Java or Python is required
- Working knowledge of OOD principles is preferred.
- Priorexperience in the detection, annotation, and prioritization/filtering of germline or somatic variants from NGS data is required.
- Experience performing statistical analysis on large data sets, including proficiency in R, is preferred.
- Excellent communication and effective problem-solving skills; and ability to interact with multidisciplinary staff in a fast-paced environment. The successful candidate should be able to work independently, prioritize and manage a variety of tasks, and shift priorities rapidly.
- Prior experience developing software in a CLIA regulated environment is preferred
Requeriments :
Skills :
- Cancer Genomics
- LIMS
- molecular biology
- Next Generation Sequencing
- Programing in Python
- Programming in Java
- Programming in R
- Statistics
Areas :
Additional Info:
The Center for Advanced Molecular Diagnostics (CAMD) is the clinical molecular diagnostics laboratory for three Harvard Medical School hospitals: Brigham and Women's Hospital, Dana-Farber Cancer Institute, and for the pediatric cancer patients of Boston Children's Hospital. Our mission is to provide innovative molecular and cytogenetic diagnostic services to assist with the clinical care of patients in our hospitals and affiliated clinics, with a primary focus on cancer care. Primary Location : MA-Boston-Boston - BWH Main Campus Work Locations : Boston - BWH Main Campus 75 Francis St Boston 02115 Job : Biomedical Organization: Brigham & Women's Hospital(BWH) Schedule : Full-time Standard Hours : 40 Shift : Day Job Employee Status : Regular Recruiting Department : BWH Pathology [Click Here to Access the Original Job Post]