Job Description:
We are looking for superstar computational-biologists/bioinformaticists who have demonstrated experience in a large-scale "production" setting to deploy, maintain and evolve the clinical bioinformatics framework for a high-throughput, ultra-rapid turnaround time, Illumina based whole-genome sequencing setting. You will have the opportunity to be a part of a team that'll build the framework ground up using the latest and greatest of the technologies in infrastructure, data storage and analytics, with a strong focus on automation, systems integration and process engineering. You will be part of a growing informatics team, consisting of bioinformaticists, software engineers, HPC engineers and data scientists. The environment is highly cross-functional, with a rich medical research heritage and multitude of collaborations with the biotech industry, academic institutions and federal programs. The end deliverable from your work each day, will tangibly influence the quality of life of the sickest children being seen at the hospital, making your work experience exciting, challenging, rewarding and meaningful. And to top it all, you'll be located in one the finest cities in the country, with a wonderful year-round weather and a multitude of outdoor activity options. What you'll do: -Adhere to compliance requirements (CAP/CLIA). -Maintain "production grade and professional quality" bioinformatics workflows for next-gen sequencing data -Maintain and evolve validation platform for the informatics components. -Institute QC and QA to ensure quality of data getting out the door. -Deploy bioinformatics pipelines on local linux HPC cluster as well as on public cloud. -Debug issues, communicate and document them. -Integrate bioinformatics workflows with LIMS. -Organize genomic data on local and cloud locations, interact with collaborators worldwide on data logistics -Manage genomic data life-cycle (creation to archival and restore). -Create and maintain documentation surrounding the analysis framework. -Evaluate NGS analysis tools, benchmark them and generate reports. -Interface with software engineers, wet-lab technicians, clinical geneticists and a wide variety of other stake holders, to communicate issues and gather feedback. -Generate and present reports on operations, validation and benchmarking Requirements: -2+ years analyzing next-gen sequencing data (Illumina whole genomes or exomes): BCL to annotated variants within a CAP/CLIA setting. -4+ years developing and maintaining pipelines for 24x7 automated bioinformatics analyses. -4+ years working with and understanding of open source NGS tools like bwa, samtools, vcftools, picard, GATK, Freebayes, ANNOVAR, VEP, etc. -2+ years incorporating dbGaP, 1000 genomes, ExAC, Clinvar, OMIM, etc. -4+ years with unix/linux operating system. -4+ years of software development using any of Ruby, Python, Perl, Bash. Perfered Skills: -2+ years of active use of SVN or git. -2+ years working with HPC scheduling systems such as Moab, TORQUE, LSF or OpenGrid Engine. -2+ years integrating pipeline with the LIMS. -Cloud-based development or analysis. -Working with R. -Performing benchmarking of bioinformatics tools. -Developing and working with Docker and AWS images. -Bioinformatics pipeline development using any workflow manager. -Setting up and computing on a hadoop cluster. -in CNV and SV calling. -Phenotype-genotype integration frameworks. Education: -Bachelor's degree in Computer Science, Information Systems, Bioinformatics or Life Sciences, including fields, i.e., Biology, Molecular Biology, Genetics. -Master's degree preferred.
Additional Info:
About TEKsystems: Join TEKsystems®, a leading IT staffing, IT talent management and IT services firm, and get your career on the fast track. We have more than 100 offices worldwide, and we partner with over 6,000 clients and place over 80,000 consultants per year. At TEKsystems, we seek to understand our consultants' skills, goals and interests, allowing us to present targeted job opportunities on a contract, contract-to-hire or direct placement basis. TEKsystems' leadership in the market stems from our sincere and personal commitment to driving the success of our customers, consultants and each other. The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, genetic information or any other characteristic protected by law. If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please call 888 472-3411 or email accommodation@teksystems.com for other accommodation options.[Click Here to Access the Original Job Post]
We are looking for superstar computational-biologists/bioinformaticists who have demonstrated experience in a large-scale "production" setting to deploy, maintain and evolve the clinical bioinformatics framework for a high-throughput, ultra-rapid turnaround time, Illumina based whole-genome sequencing setting. You will have the opportunity to be a part of a team that'll build the framework ground up using the latest and greatest of the technologies in infrastructure, data storage and analytics, with a strong focus on automation, systems integration and process engineering. You will be part of a growing informatics team, consisting of bioinformaticists, software engineers, HPC engineers and data scientists. The environment is highly cross-functional, with a rich medical research heritage and multitude of collaborations with the biotech industry, academic institutions and federal programs. The end deliverable from your work each day, will tangibly influence the quality of life of the sickest children being seen at the hospital, making your work experience exciting, challenging, rewarding and meaningful. And to top it all, you'll be located in one the finest cities in the country, with a wonderful year-round weather and a multitude of outdoor activity options. What you'll do: -Adhere to compliance requirements (CAP/CLIA). -Maintain "production grade and professional quality" bioinformatics workflows for next-gen sequencing data -Maintain and evolve validation platform for the informatics components. -Institute QC and QA to ensure quality of data getting out the door. -Deploy bioinformatics pipelines on local linux HPC cluster as well as on public cloud. -Debug issues, communicate and document them. -Integrate bioinformatics workflows with LIMS. -Organize genomic data on local and cloud locations, interact with collaborators worldwide on data logistics -Manage genomic data life-cycle (creation to archival and restore). -Create and maintain documentation surrounding the analysis framework. -Evaluate NGS analysis tools, benchmark them and generate reports. -Interface with software engineers, wet-lab technicians, clinical geneticists and a wide variety of other stake holders, to communicate issues and gather feedback. -Generate and present reports on operations, validation and benchmarking Requirements: -2+ years analyzing next-gen sequencing data (Illumina whole genomes or exomes): BCL to annotated variants within a CAP/CLIA setting. -4+ years developing and maintaining pipelines for 24x7 automated bioinformatics analyses. -4+ years working with and understanding of open source NGS tools like bwa, samtools, vcftools, picard, GATK, Freebayes, ANNOVAR, VEP, etc. -2+ years incorporating dbGaP, 1000 genomes, ExAC, Clinvar, OMIM, etc. -4+ years with unix/linux operating system. -4+ years of software development using any of Ruby, Python, Perl, Bash. Perfered Skills: -2+ years of active use of SVN or git. -2+ years working with HPC scheduling systems such as Moab, TORQUE, LSF or OpenGrid Engine. -2+ years integrating pipeline with the LIMS. -Cloud-based development or analysis. -Working with R. -Performing benchmarking of bioinformatics tools. -Developing and working with Docker and AWS images. -Bioinformatics pipeline development using any workflow manager. -Setting up and computing on a hadoop cluster. -in CNV and SV calling. -Phenotype-genotype integration frameworks. Education: -Bachelor's degree in Computer Science, Information Systems, Bioinformatics or Life Sciences, including fields, i.e., Biology, Molecular Biology, Genetics. -Master's degree preferred.
Requeriments :
Skills :
- HPC
- LIMS
- Lunix/Unix
- Next Generation Sequencing
- Programing in Python
- Programming in PERL
- Programming in R
- Software Design
Areas :
Additional Info:
About TEKsystems: Join TEKsystems®, a leading IT staffing, IT talent management and IT services firm, and get your career on the fast track. We have more than 100 offices worldwide, and we partner with over 6,000 clients and place over 80,000 consultants per year. At TEKsystems, we seek to understand our consultants' skills, goals and interests, allowing us to present targeted job opportunities on a contract, contract-to-hire or direct placement basis. TEKsystems' leadership in the market stems from our sincere and personal commitment to driving the success of our customers, consultants and each other. The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, genetic information or any other characteristic protected by law. If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please call 888 472-3411 or email accommodation@teksystems.com for other accommodation options.[Click Here to Access the Original Job Post]