Job ID: 328886591
Job date: 2017-05-01
End Date:
Company : Yumanity Therapeutics Country : Role : Other
Job date: 2017-05-01
End Date:
Company : Yumanity Therapeutics Country : Role : Other
Job Description:
The computational biologist will work as part of the target identification team, which uses large-scale chemical genetic analysis to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team. Responsibilities: -Work collaboratively with computational biologists and lab scientists to analyze and interpret experimental data to identify the molecular targets of compounds identified in phenotypic screens. -Analyze high-throughput chemical genetics data to elucidate cellular pathways and targets related to the mechanism of action for novel compounds. -Variant identification from whole genome sequence data. -Contribute to the development of Yumanity’s proprietary target identification computation pipeline. -Write scripts to implement and extend established bioinformatic tools to analyze internal and public data sets. -Analyze and perform statistical analysis of diverse data sets (from both high- and low-throughput experiments) generated by Yumanity’s scientists from the target identification, yeast, mammalian and chemistry groups. -Develop biological models and specific hypotheses based on computational analysis that will be experimentally tested.
Additional Info:
Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.[Click Here to Access the Original Job Post]
The computational biologist will work as part of the target identification team, which uses large-scale chemical genetic analysis to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team. Responsibilities: -Work collaboratively with computational biologists and lab scientists to analyze and interpret experimental data to identify the molecular targets of compounds identified in phenotypic screens. -Analyze high-throughput chemical genetics data to elucidate cellular pathways and targets related to the mechanism of action for novel compounds. -Variant identification from whole genome sequence data. -Contribute to the development of Yumanity’s proprietary target identification computation pipeline. -Write scripts to implement and extend established bioinformatic tools to analyze internal and public data sets. -Analyze and perform statistical analysis of diverse data sets (from both high- and low-throughput experiments) generated by Yumanity’s scientists from the target identification, yeast, mammalian and chemistry groups. -Develop biological models and specific hypotheses based on computational analysis that will be experimentally tested.
Skills :
Areas :
Additional Info:
Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.[Click Here to Access the Original Job Post]