Job ID: 10900
Job date: 2017-01-04
End Date:
Company : Takeda Pharmaceuticals Country : Role : Research Scientist
Job date: 2017-01-04
End Date:
Company : Takeda Pharmaceuticals Country : Role : Research Scientist
Job Description:
OBJECTIVES: -Design, implement and execute state-of-the-art bioinformatic tools for the collection, curation, analysis, mining and visualization of complex biological data. -Identify pharmacological mechanisms and adverse outcome pathways that are related to the observation of in vivo toxicity, and propose actionable and testable solutions. -Enable the design and selection of high-quality drug candidates through the identification of project-related safety liabilities and application of validated in silico and in vitro tools. ACCOUNTABILITIES: -Integrate into early discovery project teams, assist in the identification of on- and off-target pharmacology risks and identify de-risking strategies. -Develop and apply bioinformatic tools to assist in the curation, analysis and visualization of large-scale, complex toxicological datasets from multiple sources. -Work collaboratively on computational projects across multiple disciplinary areas, including DMPK, medicinal chemistry, drug safety and pharmacology. -Design new computational biology tools and applications that are relevant to the design of drugs with the safest pharmacological profile. -Drive the improvement of early risk assessment strategies through the identification of toxicological pathways that are applicable across all therapeutic areas. -Develop and maintain global platforms that integrate internal and external bioinformatic tools and models. Qualifications: EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: -PhD in computational biology, bioinformatics or equivalent. -Passion to decrease safety related attrition in drug discovery. -Demonstrated experience in data curation, data mining and an ability to interrogate, interpret, and visualize large and diverse, biological and toxicological datasets. -Demonstrated ability to independently develop and implement computational workflows starting from raw data through analysis, hypothesis generation and visualization. -Understanding of all aspects of drug discovery including cell and molecular biology, medicinal chemistry and basic principles of drug pharmacokinetics and metabolism. -Demonstrated experience in leveraging in silico methodologies to drive drug discovery projects. -Familiarity with proteomic and genomic data analysis and systems biology software. -Experience with programming and scripting languages (e.g. Perl, C/C++, Java, R, Python). -Demonstrated experience and ability to work effectively in a matrix, global environment as part of a multidisciplinary team. -Skilled in clearly communicating complex computational approaches and methodology to non-computational scientists -Pre-clinical or clinical drug safety experience is desirable. -Strong, written, oral communication and influencing skills are essential. PHYSICAL DEMANDS: Typical office base. TRAVEL REQUIREMENTS: 10%, both domestic and international possible.
Additional Info:
More than 30,000 Takeda employees working in more than 70 countries are committed to improving quality of life for patients, who remain at the center of everything we do. Takeda Pharmaceutical Company Limited is a global, research and development-driven organization working internally and with external partners to translate science into life-changing medicines. Takeda focuses on the core therapeutic areas of oncology, gastroenterology, central nervous system and providing vaccines that address the most important infectious diseases. Novel products, especially in oncology and gastroenterology, as well as our presence in emerging markets, fuel our growth. Takeda Pharmaceuticals U.S.A., Inc. ranks among the top 15 pharmaceutical companies in the United States. Our larger U.S. offices are in Cambridge, MA, Deerfield, IL, and San Diego, CA. Research & Development employees in our Cambridge location focus on oncology, gastroenterology, immunomodulation, biologics, translational research, and external innovation. In March 2016, we opened our newest space at 300 Massachusetts Avenue, featuring 230,000 square feet of state-of-the-art office and lab space. While Takeda is enjoying tremendous growth as an emerging global leader in the pharmaceutical industry, we remain ever mindful of our commitment to serve people worldwide by striving toward better health through leading innovation in medicine. In short, we are a passionate team doing important work that impacts patients’ lives. If you are driven to create better health and a brighter future, join us![Click Here to Access the Original Job Post]
OBJECTIVES: -Design, implement and execute state-of-the-art bioinformatic tools for the collection, curation, analysis, mining and visualization of complex biological data. -Identify pharmacological mechanisms and adverse outcome pathways that are related to the observation of in vivo toxicity, and propose actionable and testable solutions. -Enable the design and selection of high-quality drug candidates through the identification of project-related safety liabilities and application of validated in silico and in vitro tools. ACCOUNTABILITIES: -Integrate into early discovery project teams, assist in the identification of on- and off-target pharmacology risks and identify de-risking strategies. -Develop and apply bioinformatic tools to assist in the curation, analysis and visualization of large-scale, complex toxicological datasets from multiple sources. -Work collaboratively on computational projects across multiple disciplinary areas, including DMPK, medicinal chemistry, drug safety and pharmacology. -Design new computational biology tools and applications that are relevant to the design of drugs with the safest pharmacological profile. -Drive the improvement of early risk assessment strategies through the identification of toxicological pathways that are applicable across all therapeutic areas. -Develop and maintain global platforms that integrate internal and external bioinformatic tools and models. Qualifications: EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: -PhD in computational biology, bioinformatics or equivalent. -Passion to decrease safety related attrition in drug discovery. -Demonstrated experience in data curation, data mining and an ability to interrogate, interpret, and visualize large and diverse, biological and toxicological datasets. -Demonstrated ability to independently develop and implement computational workflows starting from raw data through analysis, hypothesis generation and visualization. -Understanding of all aspects of drug discovery including cell and molecular biology, medicinal chemistry and basic principles of drug pharmacokinetics and metabolism. -Demonstrated experience in leveraging in silico methodologies to drive drug discovery projects. -Familiarity with proteomic and genomic data analysis and systems biology software. -Experience with programming and scripting languages (e.g. Perl, C/C++, Java, R, Python). -Demonstrated experience and ability to work effectively in a matrix, global environment as part of a multidisciplinary team. -Skilled in clearly communicating complex computational approaches and methodology to non-computational scientists -Pre-clinical or clinical drug safety experience is desirable. -Strong, written, oral communication and influencing skills are essential. PHYSICAL DEMANDS: Typical office base. TRAVEL REQUIREMENTS: 10%, both domestic and international possible.
Requeriments :
Skills :
- Bioinformatics
- Biology
- Cell Biology
- Computational Biology
- molecular biology
- Programing in C
- Programing in C++
- Programing in Python
- Programing Skills
- Programming in Java
- Programming in PERL
- Programming in R
Areas :
Additional Info:
More than 30,000 Takeda employees working in more than 70 countries are committed to improving quality of life for patients, who remain at the center of everything we do. Takeda Pharmaceutical Company Limited is a global, research and development-driven organization working internally and with external partners to translate science into life-changing medicines. Takeda focuses on the core therapeutic areas of oncology, gastroenterology, central nervous system and providing vaccines that address the most important infectious diseases. Novel products, especially in oncology and gastroenterology, as well as our presence in emerging markets, fuel our growth. Takeda Pharmaceuticals U.S.A., Inc. ranks among the top 15 pharmaceutical companies in the United States. Our larger U.S. offices are in Cambridge, MA, Deerfield, IL, and San Diego, CA. Research & Development employees in our Cambridge location focus on oncology, gastroenterology, immunomodulation, biologics, translational research, and external innovation. In March 2016, we opened our newest space at 300 Massachusetts Avenue, featuring 230,000 square feet of state-of-the-art office and lab space. While Takeda is enjoying tremendous growth as an emerging global leader in the pharmaceutical industry, we remain ever mindful of our commitment to serve people worldwide by striving toward better health through leading innovation in medicine. In short, we are a passionate team doing important work that impacts patients’ lives. If you are driven to create better health and a brighter future, join us![Click Here to Access the Original Job Post]