Job ID: 583811
Job date: 2016-06-21
End Date:

Company : German Cancer Research Center (DKFZ)

Country :

[Click Here to Access the Original Job Post]

Job Description:
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 2,700 employees, we operate an extensive scientific program in the field of cancer research. The Division of Applied Functional Genomics is seeking a

Computational Biologist

Integrative Analysis of Pan-Cancer and Tumor Type-Specific Genome Data (Ref-No. 151/2016) Description: Come work on the frontier of cancer genomics. What do rare recurrent mutations do? How do cancer mutations functionally group by phenotype? How do they genetically interact with each other and with drugs? How can we exploit these for better cancer treatments? The position is part of an exciting new collaboration between the European Molecular Biology Laboratory Heidelberg (EMBL; Wolfgang Huber), the German Cancer Research Center (DKFZ; Michael Boutros, Claudia Scholl, Benedikt Brors), the National Center for Tumor Diseases Heidelberg (NCT; Stefan Fröhling) and Heidelberg University (Ingrid Lohmann) to systematically uncover the biological function of cancer mutations and their impact on cellular networks. Cancer genomics (such as our own efforts at DKFZ and NCT as well as ICGC, TCGA) has provided us with comprehensive catalogs of somatic cancer mutations, which we now aim to exploit for the development of ‘omics’-informed medicine. However, most of the mutations have unclear biological relevance. This challenge is addressed within our new collaborative research program that aims to systematically annotate the function and relevance of altered genes and their networks in cancer, using systematic arrays of large-scaleCRISPR/Cas9 screens in panels of human cell lines engineered to carry uncharacterized cancer mutations. The successful candidate will develop and apply strategies for the integrative analysis of pan-cancer and tumor type-specific genome data (e.g. from whole-exome and whole-genome sequencing, RNA sequencing), enabling the identification and prioritization of biologically relevant cancer mutations, which will be further characterized functionally. These analyses will give us insights into the function of unknown genetic variants, and will highlight new drug targets and repurposing opportunities. The position will be shared between the groups of Benedikt Brors (Applied Bioinformatics, DKFZ), Claudia Scholl (Applied Functional Genomics, DKFZ) and Stefan Fröhling (Molecular and Cellular Oncology, NCT). The position holder will closely collaborate with the entire team of the joint research program. The position is based at DFKZ. Please contact B. Brors, S. Fröhling or C. Scholl for any further information. Your profile: · The position requires outstanding quantitative and analytical skills. Applicants should hold a Ph.D. or equivalent in bioinformatics, computer science, biology, biochemistry, biotechnology or a related field and have a track record in international peer-reviewed journals. · Knowledge in the analysis of next-generation sequencing data is required. · The successful candidate is highly motivated, ambitious, hard-working, able to work independently and has strong communication and team working skills. · Curiosity to work in interdisciplinary projects and continuously expand your horizon is expected. · An excellent written and oral command of English is essential. · The candidate has a good understanding of molecular and cancer biology. · Experience in statistical analysis, Bioconductor/R, bash programming and a scripting language, such as Perl or Python, is of advantage. · Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2-3 references. The position is limited to 2 years. The position can in principle be part-time. For further information please contact Lena Fuchs, phone 06221 42-1633. The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference. To apply for a position please use our online application portal (www.dkfz.de). We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Requeriments :

Skills :

Areas :

Additional Info:

[Click Here to Access the Original Job Post]