Job ID: 84484
Job date: 2018-01-09
End Date:
Company : Lawrence Berkeley National Laboratory Country : Role : Postdoc
Job date: 2018-01-09
End Date:
Company : Lawrence Berkeley National Laboratory Country : Role : Postdoc
Job Description:
Berkeley Lab’s Biological Systems and Engineering Division has an opening for a Computational Biologist Postdoctoral Scholar. This position will be part of the Host Engineering group led by Dr. Aindrila Mukhopadhyay, and part of the Biofuel and Bioproducts Division at the Joint BioEnergy Institute. JBEI recently received funding as a Department of Energy (DOE) Bioenergy Research Centers (BRC) and seeks to address key challenges in developing robust and scalable microbial processes to produce biofuels and bioproducts from renewable carbon sources. The Host Engineering group will examine and understand microbial physiology during expression of heterologous or non-natural biosynthetic pathways and in industrially relevant conditions. You will be involved in using systems biology methods, functional genomics and biosensors to examine the phenotypic drift in engineered strains during subculturing and transition across growth media and scales. You will engineer the microbial host strain, pathways and genetic control systems, to maintain high production parameters for longer durations. What You Will Do:
Additional Info:
The posting shall remain open until the position is filled, however for full consideration, please apply by close of business on February 9, 2018. Notes: This is a full time, 2 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree. Full-time, M-F, exempt (monthly paid) from overtime pay. This position is represented by a union for collective bargaining purposes. Salary will be predetermined based on postdoctoral step rates. This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment. Work will be primarily performed at: Joint BioEnergy Institute (JBEI) — Bldg. 978, 5885 Hollis St., 4th floor, Emeryville, CA. Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science. Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."[Click Here to Access the Original Job Post]
Berkeley Lab’s Biological Systems and Engineering Division has an opening for a Computational Biologist Postdoctoral Scholar. This position will be part of the Host Engineering group led by Dr. Aindrila Mukhopadhyay, and part of the Biofuel and Bioproducts Division at the Joint BioEnergy Institute. JBEI recently received funding as a Department of Energy (DOE) Bioenergy Research Centers (BRC) and seeks to address key challenges in developing robust and scalable microbial processes to produce biofuels and bioproducts from renewable carbon sources. The Host Engineering group will examine and understand microbial physiology during expression of heterologous or non-natural biosynthetic pathways and in industrially relevant conditions. You will be involved in using systems biology methods, functional genomics and biosensors to examine the phenotypic drift in engineered strains during subculturing and transition across growth media and scales. You will engineer the microbial host strain, pathways and genetic control systems, to maintain high production parameters for longer durations. What You Will Do:
- Develop a suite of genetic control systems and biosensors than work efficiently in the aromatic metabolizer P. putida, the main microbial host being used at JBEI.
- Develop high throughput assays to evaluate strain physiology during scale up and other industrially relevant growth conditions (growth media containing different carbon sources, fed batch, higher scales).
- Conduct a suite of systems biology and functional genomics experiments to generate a model for P. putida physiology across key industrially relevant growth conditions.
- Increase the strain capacity maintain high productivity for longer periods of time.
- Prepare manuscripts for publication and assist with the development of funding proposals and patents.
- Participate in group meetings and seminars.
- Maintain an accurate and detailed scientific logbook of all experiments performed. Ensure that others could duplicate results.
- Responsible for periodic reports to the director of the project, participation in group meetings.
- Participate in training research assistants and assisting others in the lab who require guidance with computational methods and data analysis.
- Take responsibility of a key piece of equipment or lab area.
- Maintain an electronic lab notebook, maintain appropriate records and manage data.
- Provide detailed six monthly reports that can be used as part of manuscript for peer reviewed journals.
- Recent Ph.D in Computational biology, Microbiology, Biochemistry, Molecular Biology, or a related area.
- Expert knowledge in bioinformatics and computational tools to analyze and model systems biology and high throughput assay data.
- Experience in functional genomics, synthetic biology, gene regulation and stress response in bacteria.
- Knowledge in handling microbes such as P. putida including growth, culturing, transformation, gene manipulation, creation of expression systems and protein purification.
- Ability to conduct original work that meets the milestones of a larger project and scientific program.
- Experience with scientific journal writing submissions and ability to write above average reviews and articles for submission.
- Experience with equipment like bioreactors, liquid handling systems, cell sorters and FACS.
Requeriments :
Skills :
Areas :
Additional Info:
The posting shall remain open until the position is filled, however for full consideration, please apply by close of business on February 9, 2018. Notes: This is a full time, 2 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree. Full-time, M-F, exempt (monthly paid) from overtime pay. This position is represented by a union for collective bargaining purposes. Salary will be predetermined based on postdoctoral step rates. This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment. Work will be primarily performed at: Joint BioEnergy Institute (JBEI) — Bldg. 978, 5885 Hollis St., 4th floor, Emeryville, CA. Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science. Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."[Click Here to Access the Original Job Post]