Job Description:
External Posting Title
Computational Scientist, NGS QC & Analysis Pipeline Lead
Job Description
Biogen is committed to developing novel, disease modifying therapies for neurodegenerative diseases. Do you want to help Biogen develop ground breaking therapies for ALS, Alzheimer’s Disease and Parkinson’s Disease? The Computational Biology & Genomics (GB&G) department is seeking a passionate computational scientist to be the scientific and intellectual lead to drive the development of advanced QC and Analysis Pipelines for Next-Generation Sequencing (NGS) applications across research and development. CB&G collaborates with discovery, clinical development and manufacturing scientists to apply a variety of NGS techniques to enable novel target, biomarker, and compound mode of action discovery. This position will be the NGS data subject matter expert responsible for defining the key QC analysis and metrics needed for specific NGS applications as well as defining the best analysis pipelines that are aligned with community best practices where applicable. The successful candidate will be deeply interested in comparing performance of algorithms and the effects of different QC metrics and will be sufficiently familiar with experimental design principles to ensure the most effective pipelines are employed resulting in the delivery of high quality data to our scientists. The person will work closely with the NGS core scientists, computational biologists and statistical geneticists to understand the assays deployed, gather requirements for down-stream analysis and translate those into the appropriate QC and processing pipelines. The person will be able to prototype pipelines and work with software architects/engineers in the IT-Scientific Computing group to turn into production software. The successful candidate will be skilled at working in a highly matrixed, collaborative research environment as well as maintain and foster a strong network with the key academic and genome centers to ensure Biogen’s NGS QC & analysis pipelines are aligned to community standards. Biogen is committed to training and mentorship for candidates with the drive and motivation to learn and apply NGS technologies to drug discovery.
*LI-RD2
Location
Cambridge, MA, US
Job Category
Research
Requisition Number
24271BR
Qualifications
Required:
• Strong foundation in computational and statistical principles
• Experience processing and analyzing large datasets
• Ability to understand and compare computational/statistical algorithms
• Excellent written and oral communication skills
• Ability to learn and adapt quickly to new projects/areas that have not worked on previously (i.e. dealing with new NGS assays)
• Experience in a Linux environment and HPC environment (e.g. SGE)
• Experience in statistical programming (e.g. R/Matlab)
• Experience in scripting languages for prototyping pipelines (e.g. shell scpriting, Perl, Python)
Highly Desirable:
• Strong understanding of NGS technology and ability to understand subtleties of different methods and impacts of data generation and QC
• Ability to design simulations or experiments to compare competing algorithms for specific NGS assays & analysis questions
• Experience with a variety of NGS protocols (e.g. WGS, WES, RNA-seq, ChIP-seq, ATAC-seq)
• Experience with community leading NGS analysis tools (e.g. BWA, STAR, Picard, GATK, DESeq/RSEM, etc.)
• Experience developing novel QC algorithms and visualizations
• Demonstrated ability to work successfully in cross-functional teams (IT, bioinformatics and biologists)
Education
M.S. in Bioinformatics, Computational Biology, Computer Science, Genetics, Mathematics/Statistics or related field/experience; Ph.D. preferred.
About Biogen
Biogen (NASDAQ: BIIB) is a biotechnology leader that discovers, develops and delivers innovative therapies to improve the lives of patients with neurodegenerative diseases, hematologic conditions and autoimmune diseases. Patients worldwide benefit every day from our medicines for multiple sclerosis (MS) and hemophilia.
Founded in 1978, Biogen is one of the world’s oldest biotechnology companies. Our development pipeline is focused on areas of high unmet medical need, as we pursue new therapies for patients suffering from diseases with few or no treatment options. These include programs for secondary progressive MS, Alzheimer’s Disease, spinal muscular atrophy, lupus and amyotrophic lateral sclerosis (ALS), amongst others.
With approximately 7,500 people worldwide, Biogen is truly a global organization. We are headquartered in Cambridge, Massachusetts, which is home to our research operations. Our international operations are based in Zug, Switzerland and we have world-class manufacturing facilities in North Carolina and Denmark. We offer therapies globally through direct affiliate presence in 30 countries and a network of distribution partners in over 50 additional countries.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.
Please be advised that all legitimate correspondence from a Biogen employee will come from "@biogen.com" or "@biogenidec.com" email accounts.
Additional Info:
[Click Here to Access the Original Job Post]
External Posting Title
Computational Scientist, NGS QC & Analysis Pipeline Lead
Job Description
Biogen is committed to developing novel, disease modifying therapies for neurodegenerative diseases. Do you want to help Biogen develop ground breaking therapies for ALS, Alzheimer’s Disease and Parkinson’s Disease? The Computational Biology & Genomics (GB&G) department is seeking a passionate computational scientist to be the scientific and intellectual lead to drive the development of advanced QC and Analysis Pipelines for Next-Generation Sequencing (NGS) applications across research and development. CB&G collaborates with discovery, clinical development and manufacturing scientists to apply a variety of NGS techniques to enable novel target, biomarker, and compound mode of action discovery. This position will be the NGS data subject matter expert responsible for defining the key QC analysis and metrics needed for specific NGS applications as well as defining the best analysis pipelines that are aligned with community best practices where applicable. The successful candidate will be deeply interested in comparing performance of algorithms and the effects of different QC metrics and will be sufficiently familiar with experimental design principles to ensure the most effective pipelines are employed resulting in the delivery of high quality data to our scientists. The person will work closely with the NGS core scientists, computational biologists and statistical geneticists to understand the assays deployed, gather requirements for down-stream analysis and translate those into the appropriate QC and processing pipelines. The person will be able to prototype pipelines and work with software architects/engineers in the IT-Scientific Computing group to turn into production software. The successful candidate will be skilled at working in a highly matrixed, collaborative research environment as well as maintain and foster a strong network with the key academic and genome centers to ensure Biogen’s NGS QC & analysis pipelines are aligned to community standards. Biogen is committed to training and mentorship for candidates with the drive and motivation to learn and apply NGS technologies to drug discovery.
*LI-RD2
Location
Cambridge, MA, US
Job Category
Research
Requisition Number
24271BR
Qualifications
Required:
• Strong foundation in computational and statistical principles
• Experience processing and analyzing large datasets
• Ability to understand and compare computational/statistical algorithms
• Excellent written and oral communication skills
• Ability to learn and adapt quickly to new projects/areas that have not worked on previously (i.e. dealing with new NGS assays)
• Experience in a Linux environment and HPC environment (e.g. SGE)
• Experience in statistical programming (e.g. R/Matlab)
• Experience in scripting languages for prototyping pipelines (e.g. shell scpriting, Perl, Python)
Highly Desirable:
• Strong understanding of NGS technology and ability to understand subtleties of different methods and impacts of data generation and QC
• Ability to design simulations or experiments to compare competing algorithms for specific NGS assays & analysis questions
• Experience with a variety of NGS protocols (e.g. WGS, WES, RNA-seq, ChIP-seq, ATAC-seq)
• Experience with community leading NGS analysis tools (e.g. BWA, STAR, Picard, GATK, DESeq/RSEM, etc.)
• Experience developing novel QC algorithms and visualizations
• Demonstrated ability to work successfully in cross-functional teams (IT, bioinformatics and biologists)
Education
M.S. in Bioinformatics, Computational Biology, Computer Science, Genetics, Mathematics/Statistics or related field/experience; Ph.D. preferred.
About Biogen
Biogen (NASDAQ: BIIB) is a biotechnology leader that discovers, develops and delivers innovative therapies to improve the lives of patients with neurodegenerative diseases, hematologic conditions and autoimmune diseases. Patients worldwide benefit every day from our medicines for multiple sclerosis (MS) and hemophilia.
Founded in 1978, Biogen is one of the world’s oldest biotechnology companies. Our development pipeline is focused on areas of high unmet medical need, as we pursue new therapies for patients suffering from diseases with few or no treatment options. These include programs for secondary progressive MS, Alzheimer’s Disease, spinal muscular atrophy, lupus and amyotrophic lateral sclerosis (ALS), amongst others.
With approximately 7,500 people worldwide, Biogen is truly a global organization. We are headquartered in Cambridge, Massachusetts, which is home to our research operations. Our international operations are based in Zug, Switzerland and we have world-class manufacturing facilities in North Carolina and Denmark. We offer therapies globally through direct affiliate presence in 30 countries and a network of distribution partners in over 50 additional countries.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.
Please be advised that all legitimate correspondence from a Biogen employee will come from "@biogen.com" or "@biogenidec.com" email accounts.
Requeriments :
Skills :
- Bioinformatics
- Biology
- Computational Biology
- Genetics
- HPC
- Programing Skills
- Programming in Matlab
- Programming in R
- RNA-seq
- Statistics
Areas :
Additional Info:
[Click Here to Access the Original Job Post]