Job Description:
The MRL B+V, DMPK & Disposition is seeking an individual with deep expertise in the area of Drug Development and quantitative sciences with application to development of biotherapeutics (monoclonal antibodies, therapeutic proteins, nanobodies, and multi-specific biologics). The individual will lead the newly formed group in Boston and serves and manages the critical and relevant activities at our Merck Research site in Boston, MA. The position will be a critical member of the function providing strong expertise necessary for development of:
Additional Info:
Principal Scientist DMPK Disposition based in Boston. This is not an entry level position. The MRL Biologics and Vaccines Discovery (MRL, B+V) , DMPK and Disposition function focuses strongly on application of integrative pharmacology and systems pharmacology approaches for preclinical development of various biologics modalities. These modalities address diverse therapeutic areas such as immunology, oncology, immuno-oncology, infectious and cardio-metabolic diseases.[Click Here to Access the Original Job Post]
The MRL B+V, DMPK & Disposition is seeking an individual with deep expertise in the area of Drug Development and quantitative sciences with application to development of biotherapeutics (monoclonal antibodies, therapeutic proteins, nanobodies, and multi-specific biologics). The individual will lead the newly formed group in Boston and serves and manages the critical and relevant activities at our Merck Research site in Boston, MA. The position will be a critical member of the function providing strong expertise necessary for development of:
- Drug and combination therapeutic concepts and dose predictions for the design and conduct of preclinical efficacy and nonclinical safety studies in support of FIH clinical study design and dose projections
- Application of systems pharmacology principles in order to establish and build predictive preclinical frameworks with application in various therapeutic areas
- Mechanistic approaches (and in an integrated fashion) for integration of key properties such as-- target expression, gene profiles, signaling and pathways, construct properties, disease considerations-- for establishing exposure-response relationships in relevant preclinical studies and assisting in projection of doses in early human clinical studies in support of IND submissions.
- To lead, and manage the DMPK group in Boston.
- To represent the function at the project teams, and collaborate directly and closely with other members of the team and Merck Network.
- The successful candidate will apply her / his broad knowledge in drug development to engage current and future stakeholders and customers, in particular in the early Discovery space as related to systems and integrated pharmacology strategies, into project activities and to establish critical connections to the Merck network.
- The successful applicant has a strong scientific interest in drug development in the Discovery and Early Development space combined with a desire to apply her/his excellent communication and interpersonal skill in all aspects of customer and team engagement.
- Strong experience in application of quantitative sciences in drug development.
- Experience modeling/simulation programs
- Strong communication and writing skills with ability to independently function in a highly team-oriented environment.
- Biotechnology or pharmaceutical experience with protein therapeutics is a plus.
- Background and familiarity with the fundamentals of pharmacology, physiology and basic principles of drug actions, and the drug development process.
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Additional Info:
Principal Scientist DMPK Disposition based in Boston. This is not an entry level position. The MRL Biologics and Vaccines Discovery (MRL, B+V) , DMPK and Disposition function focuses strongly on application of integrative pharmacology and systems pharmacology approaches for preclinical development of various biologics modalities. These modalities address diverse therapeutic areas such as immunology, oncology, immuno-oncology, infectious and cardio-metabolic diseases.[Click Here to Access the Original Job Post]