Job Description:
The post holder will support the development of bioinformatics analytical pipelines in R or Matlab to enable the mining of omics datasets using predictive/prognostic gene expression signatures. In this role you will perform computational data analysis for a wide range of biomarker research projects, analysing large complex data sets from a variety of data types including gene expression and next generation sequencing. The Translational Research Network for Prostate Cancer (TransPot) is a pan-European academic/private/clinical sector research training network focussed on Translational Cancer Research, Cancer Cell Biology and Applied Systems Biology/Systems Medicine. TransPot will integrate the leading research scientists and laboratories in Europe with an interest in these research fields to train 11 early stage researchers (ESRs). We will incorporate the latest multi-disciplinary research technologies to understand lethal prostate cancer (PC). The TransPot consortium will offer an innovative research training programme to our ESRs to ensure that they can effectively operate in today’s multi-disciplinary programs. This will include both in silico research (e.g. target validation and drug discovery; biomarker discovery and validation) and transferable skill sets (e.g. onco-omics analysis). As a result of this unique training programme, our ESRs will develop into the next generation of multi-disciplinary scientist with skills that are in great demand for both today’s academic and non-academic sectors. The project will involve the development of bioinformatics analytical pipelines in R or Matlab to enable the mining of omics datasets using predictive/prognostic gene expression signatures, eg the DDRD and MEK assays. The developed bioinformatics method will use gene expression data to classify the biomarker status of patients across cancer types, incorporating additional omics data through cross-technology integration techniques, in order to uncover significant alterations associated with different molecular subgroups. The final output of the analytical bioinformatics pipeline will be to present integrated findings (across cancer and data types) in an intuitive report format. Working as part of the Translational Research Network for Prostate Cancer you will be a PhD student at Queen’s University Belfast and will be fully aligned with the QUB PhD programme whilst benefiting from the opportunity to gain industrial experience and expertise in biomarker discovery approaches through Almac Diagnostics. The three year fixed term post will work on the following TransPot project under the supervision of Professor Richard Kennedy and Dr Nuala McCabe: Validation of a MEKK and DDRD gene expression signature in preclinical models.
Additional Info:
THIS OPPORTUNITY IS OFFERED ON A FIXED TERM BASIS FOR A PERIOD OF 36 MONTHS Applicants should be aware that the selection of candidates will be made in accordance with the eligibility criteria for the funding of Early Stage Researchers as determined by European Commission’s Marie Curie ITN funding rules. The Almac Group is a family of six business units: Almac Clinical Services, Almac Clinical Technologies, Almac Diagnostics, Almac Discovery, Almac Pharma Services and Almac Sciences. An award winning organisation and employer headquartered in Craigavon we also have additional facilities across the UK, the USA, Singapore and Japan. Everything we do supports our core vision: to be the leader in the generation of superior solutions for the advancement of human health. We do this through our four core values: outstanding quality, superlative customer focus, exceptional innovation and inspirational people. Working at Almac is exciting, sometimes challenging but always rewarding. Over a period of sustained global growth spanning in excess of 45 years, the diligence and dedication of our 3700 strong family have made our company the success that it is today. Together we make an invaluable difference to the health of countless patients all over the world ………and this is just the beginning. Be part of something big. Be part of something special. Be part of Almac.[Click Here to Access the Original Job Post]
The post holder will support the development of bioinformatics analytical pipelines in R or Matlab to enable the mining of omics datasets using predictive/prognostic gene expression signatures. In this role you will perform computational data analysis for a wide range of biomarker research projects, analysing large complex data sets from a variety of data types including gene expression and next generation sequencing. The Translational Research Network for Prostate Cancer (TransPot) is a pan-European academic/private/clinical sector research training network focussed on Translational Cancer Research, Cancer Cell Biology and Applied Systems Biology/Systems Medicine. TransPot will integrate the leading research scientists and laboratories in Europe with an interest in these research fields to train 11 early stage researchers (ESRs). We will incorporate the latest multi-disciplinary research technologies to understand lethal prostate cancer (PC). The TransPot consortium will offer an innovative research training programme to our ESRs to ensure that they can effectively operate in today’s multi-disciplinary programs. This will include both in silico research (e.g. target validation and drug discovery; biomarker discovery and validation) and transferable skill sets (e.g. onco-omics analysis). As a result of this unique training programme, our ESRs will develop into the next generation of multi-disciplinary scientist with skills that are in great demand for both today’s academic and non-academic sectors. The project will involve the development of bioinformatics analytical pipelines in R or Matlab to enable the mining of omics datasets using predictive/prognostic gene expression signatures, eg the DDRD and MEK assays. The developed bioinformatics method will use gene expression data to classify the biomarker status of patients across cancer types, incorporating additional omics data through cross-technology integration techniques, in order to uncover significant alterations associated with different molecular subgroups. The final output of the analytical bioinformatics pipeline will be to present integrated findings (across cancer and data types) in an intuitive report format. Working as part of the Translational Research Network for Prostate Cancer you will be a PhD student at Queen’s University Belfast and will be fully aligned with the QUB PhD programme whilst benefiting from the opportunity to gain industrial experience and expertise in biomarker discovery approaches through Almac Diagnostics. The three year fixed term post will work on the following TransPot project under the supervision of Professor Richard Kennedy and Dr Nuala McCabe: Validation of a MEKK and DDRD gene expression signature in preclinical models.
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Additional Info:
THIS OPPORTUNITY IS OFFERED ON A FIXED TERM BASIS FOR A PERIOD OF 36 MONTHS Applicants should be aware that the selection of candidates will be made in accordance with the eligibility criteria for the funding of Early Stage Researchers as determined by European Commission’s Marie Curie ITN funding rules. The Almac Group is a family of six business units: Almac Clinical Services, Almac Clinical Technologies, Almac Diagnostics, Almac Discovery, Almac Pharma Services and Almac Sciences. An award winning organisation and employer headquartered in Craigavon we also have additional facilities across the UK, the USA, Singapore and Japan. Everything we do supports our core vision: to be the leader in the generation of superior solutions for the advancement of human health. We do this through our four core values: outstanding quality, superlative customer focus, exceptional innovation and inspirational people. Working at Almac is exciting, sometimes challenging but always rewarding. Over a period of sustained global growth spanning in excess of 45 years, the diligence and dedication of our 3700 strong family have made our company the success that it is today. Together we make an invaluable difference to the health of countless patients all over the world ………and this is just the beginning. Be part of something big. Be part of something special. Be part of Almac.[Click Here to Access the Original Job Post]