Job Description:
We are looking for a highly motivated microbiology Postdoctoral Research Associate to join Dr. Marjan van der Woude’s group and work in an international, interdisciplinary team to address the impact of Contact-Dependent Inhibition (CDI) on the development of mixed bacterial communities.
Bacteria often live in stable mixed communities, yet how these are maintained is poorly understood. The effect of CDI is that upon contact one bacterial strain will affect the growth of the other, and elucidating the effect of this on growing populations is the aim of this project (reviewed in Hayes et al 2014, PMC3904093). This can best be addressed in an interdisciplinary manner where the biochemistry and microbiology of CDI and population dynamics, are all considered in concert. This project’s team of five PIs brings together this expertise (Low and Hayes, USCB, USA; Van der Woude (project PI), Dytham and Wood, York, UK). The successful candidate will lead the work on assessing the effects of CDI in single cell interactions through to population level using primarily a quantitative imaging approach. This analysis will be informed by biochemical and genetic analyses carried out at UCSB and complement mathematical and computational investigations to be carried out in York. Due to the prevalence of CDI, project outputs may impact our understanding of bacterial communities in health and disease, and in the environment.
The research will be conducted in the CII at the University of York, UK, which provides state of the art facilities for pathogen related research, and will make extensive use of the resources on offer in the Biosciences Technology Facility.
This post is funded by a BBSRC/NSF bilateral grant for up to a period of three years. The starting salary will be within the range of £30,434 - £32,277 a year. You will already possess a PhD or be close to completion. The anticipated start date for this post is November 2015.
Informal enquiries may be made to Dr. Marjan van der Woude (email: marjan.vanderwoude@york.ac.uk)
We are looking for a self-motivated individual who can work independently but also is a good collaborator and team member; someone who is appreciates the value and challenges of, and is excited by interdisciplinary and collaborative research.
You will have very good skills in experimental design, execution, data documentation, analysis and reporting and apply this to assess CDI effects at single (bacterial) cell and population level. This will involve generating high quality microscopy data and performing robust, quantitative analysis of this data. You will need to perform strain manipulation as needed to carry out the best experiments. You will liaise with the collaborators and PDRA2, clearly communicating your data, and receiving and integrating their insights and data into your own experimental design.
You therefore will need to have very good knowledge of microbiology, and working knowledge of protein biochemistry and statistics as required for data analysis. You will have experience in molecular and genetic approaches, and some imaging experience. Experience with advanced imaging techniques and image analysis programmes, and strong numerical skills will be a benefit. You will have excellent oral and written communication skills. You will already possess a PhD or be close to completion.
To submit your application, please use the "Apply Through Website" button.
ABOUT THE EMPLOYER
will be based in Dr. van der Woude’s lab in the Centre for Immunology and Infection (www.york.ac.uk/cii/) at the University of York, UK. This is an interdepartmental Centre created by the Department of Biology (www.york.ac.uk/depts/biol/) and the Hull York Medical School (www.hyms.ac.uk). Research within CII ranges from fundamental studies on the pathogenesis of infectious and non-infectious disease through to first-in-man clinical research. The CII boasts world-class facilities with state of the art laboratories for handling high-risk pathogens (to ACDP HG3) and for conducting translational research. CII staff work closely with colleagues in the Department of Biology, HYMS and across the University, exemplifying York’s approach to “without walls” interdepartmental and interdisciplinary research. Research in the CII is supported by the internationally known Biosciences Technology Facility, which houses much of the core research equipment used by the CII and the Biology Department, and also by the York Clinical Research Facility. With six specialist laboratories and dedicated Laboratory Heads and technicians, the Technology Facility is an integrated part of how research is undertaken in the Department. The six laboratories comprise: Imaging and Cytometry, Proteomics, Genomics, Protein Production, Molecular Interactions, and Bioinformatics. Full details of the Technology Facility can be found at http://www.york.ac.uk/biology/technology-facility/.
The CII plays an active role in teaching in the Department of Biology and HYMS. Biology Department students take a final year research project over two terms that often takes place within a research group. At postgraduate level, the CII is a hub for the Wellcome Trust 4 year PhD program in Combating Infectious Disease: Computational Approaches in Translational Science (CIDCATS).
The 2014 REF placed The Department of Biology at the University of York in the Top 10 in the UK and 1st for impact outside academia. Further information about the Biology department is available at: http://www.york.ac.uk/biology/.
Please visit http://www.york.ac.uk for information on the University of York, and the beautiful historic city of York, UK.
Additional Info:
[Click Here to Access the Original Job Post]
We are looking for a highly motivated microbiology Postdoctoral Research Associate to join Dr. Marjan van der Woude’s group and work in an international, interdisciplinary team to address the impact of Contact-Dependent Inhibition (CDI) on the development of mixed bacterial communities.
Bacteria often live in stable mixed communities, yet how these are maintained is poorly understood. The effect of CDI is that upon contact one bacterial strain will affect the growth of the other, and elucidating the effect of this on growing populations is the aim of this project (reviewed in Hayes et al 2014, PMC3904093). This can best be addressed in an interdisciplinary manner where the biochemistry and microbiology of CDI and population dynamics, are all considered in concert. This project’s team of five PIs brings together this expertise (Low and Hayes, USCB, USA; Van der Woude (project PI), Dytham and Wood, York, UK). The successful candidate will lead the work on assessing the effects of CDI in single cell interactions through to population level using primarily a quantitative imaging approach. This analysis will be informed by biochemical and genetic analyses carried out at UCSB and complement mathematical and computational investigations to be carried out in York. Due to the prevalence of CDI, project outputs may impact our understanding of bacterial communities in health and disease, and in the environment.
The research will be conducted in the CII at the University of York, UK, which provides state of the art facilities for pathogen related research, and will make extensive use of the resources on offer in the Biosciences Technology Facility.
This post is funded by a BBSRC/NSF bilateral grant for up to a period of three years. The starting salary will be within the range of £30,434 - £32,277 a year. You will already possess a PhD or be close to completion. The anticipated start date for this post is November 2015.
Informal enquiries may be made to Dr. Marjan van der Woude (email: marjan.vanderwoude@york.ac.uk)
DESIRED SKILLS AND EXPERIENCE
We are looking for a self-motivated individual who can work independently but also is a good collaborator and team member; someone who is appreciates the value and challenges of, and is excited by interdisciplinary and collaborative research.
You will have very good skills in experimental design, execution, data documentation, analysis and reporting and apply this to assess CDI effects at single (bacterial) cell and population level. This will involve generating high quality microscopy data and performing robust, quantitative analysis of this data. You will need to perform strain manipulation as needed to carry out the best experiments. You will liaise with the collaborators and PDRA2, clearly communicating your data, and receiving and integrating their insights and data into your own experimental design.
You therefore will need to have very good knowledge of microbiology, and working knowledge of protein biochemistry and statistics as required for data analysis. You will have experience in molecular and genetic approaches, and some imaging experience. Experience with advanced imaging techniques and image analysis programmes, and strong numerical skills will be a benefit. You will have excellent oral and written communication skills. You will already possess a PhD or be close to completion.
To submit your application, please use the "Apply Through Website" button.
ABOUT THE EMPLOYER
will be based in Dr. van der Woude’s lab in the Centre for Immunology and Infection (www.york.ac.uk/cii/) at the University of York, UK. This is an interdepartmental Centre created by the Department of Biology (www.york.ac.uk/depts/biol/) and the Hull York Medical School (www.hyms.ac.uk). Research within CII ranges from fundamental studies on the pathogenesis of infectious and non-infectious disease through to first-in-man clinical research. The CII boasts world-class facilities with state of the art laboratories for handling high-risk pathogens (to ACDP HG3) and for conducting translational research. CII staff work closely with colleagues in the Department of Biology, HYMS and across the University, exemplifying York’s approach to “without walls” interdepartmental and interdisciplinary research. Research in the CII is supported by the internationally known Biosciences Technology Facility, which houses much of the core research equipment used by the CII and the Biology Department, and also by the York Clinical Research Facility. With six specialist laboratories and dedicated Laboratory Heads and technicians, the Technology Facility is an integrated part of how research is undertaken in the Department. The six laboratories comprise: Imaging and Cytometry, Proteomics, Genomics, Protein Production, Molecular Interactions, and Bioinformatics. Full details of the Technology Facility can be found at http://www.york.ac.uk/biology/technology-facility/.
The CII plays an active role in teaching in the Department of Biology and HYMS. Biology Department students take a final year research project over two terms that often takes place within a research group. At postgraduate level, the CII is a hub for the Wellcome Trust 4 year PhD program in Combating Infectious Disease: Computational Approaches in Translational Science (CIDCATS).
The 2014 REF placed The Department of Biology at the University of York in the Top 10 in the UK and 1st for impact outside academia. Further information about the Biology department is available at: http://www.york.ac.uk/biology/.
Please visit http://www.york.ac.uk for information on the University of York, and the beautiful historic city of York, UK.
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Additional Info:
[Click Here to Access the Original Job Post]