Principal Scientist I Bioinformatics, Sequencing

Listing Info Roche is the world leader in in vitro diagnostics (IVD) and tissue-based cancer diagnostics and a front runner in diabetes management. Roche Sequencing is seeking a talented developer to lead the software team within Bioinformatics to build, optimize and maintain a computational environment to enable the approval of next-generation sequencing (NGS) IVDs. This position requires an adaptable developer to address the many demands of formalizing prototype software, supporting a computational environment and working with multiple stakeholders across disciplines and departments. The position will play a critical role for the development and approval of NGS-based tests. Responsibilities

• Build and manage a team to address the software needs for Bioinformatics within Roche Sequencing.
• Formalize existing or prototype Bioinformatic workflows to achieve a more efficient, reusable and validated code base.
• Be flexible and adaptable with different user requirements, levels of user experience and programming languages.
• Establish and maintain software development standards and best practices for a range of applications for a diverse user base.
• Establish or adapt specifications for data processing, visualization and user experience.
• Work with Bioinformatics, Quality and Regulatory for designing, implementing and supporting validated software.
• Adapt or implement workflows to operate in a high performance computing infrastructure.
• Liaison with IT, bioinformatics and scientists to support the computational environment in a light-weight sequencing facility.

Qualifications

• Extensive experience with software architecture, genomics-based pipelines, data management and supporting a dynamic codebase in a regulated environment.
• Expert knowledge of software systems for version control and project management.
• Proficient with Linux system administration.
• Familiar with quality systems and the design control process.
• Familiar with R (Bioconductor).
• Familiar with LIMS applications and support.
• MS in computer science or a related field but a Ph.D. is preferred.
• Experience building and / or managing a team.
• Must be comfortable providing leadership in a competitive landscape and operating independently with incomplete information.