Job ID: RD15149
Job date: 2018-03-28
End Date:
Company : University of Cambridge Country : Role : Research Scientist
Job date: 2018-03-28
End Date:
Company : University of Cambridge Country : Role : Research Scientist
Job Description:
We are looking for a highly motivated bioinformatics/computational biology post-doctoral associate to join our collaborative research team. We aim to exploit an understanding of normal neuroblast developmental control to restart differentiation in neuroblastoma cells by targeting a key transcriptional network both genetically and with drugs. The successful candidate will work alongside experimental scientists to formulate and test hypotheses that underpin a new approach to therapy for neuroblastoma, providing bioinformatic interpretation of genome-wide datasets generated by research scientists in the Philpott lab, as well as undertake integration with data from patient cohort datasets. Work includes data processing, statistical analysis, integration and visualization of disparate datasets, development of analysis workflows and training, data management and experimental design. The successful candidate will have the opportunity to work under their own initiative and apply their problem solving skills to troubleshoot challenging issues. There is potential for someone who is primarily bioinformatically-focussed to also take part in experimental work if desired and time permitting. Applicants will have a PhD (or equivalent) and sufficient experience of genome-wide analysis techniques to work independently and within a group.
Additional Info:
Neuroblastoma is a devastating paediatric cancer of the peripheral nervous system that causes 15% of all children's cancer deaths in the UK each year. Neuroblastoma arises from neuroblasts that fail to complete their normal developmental programme but are instead locked in a state of enhanced proliferation and inhibited differentiation. Our group is embedded within the world-class infrastructure on the Cambridge Biomedical Campus, in the the Department of Oncology at the University of Cambridge (https://www.oncology.cam.ac.uk/research/) and will be moving to the newly constructed Wellcome-MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk) in Autumn 2018. We work closely with Dr Jason Carroll in the CRUK Cambridge Institute, Prof. Ben Simons in the Stem Cell Institute and other research groups nationally and internationally to advance research on developing new treatments for neuroblastoma. Please contact Prof. Anna Philpott (ap113@cam.ac.uk) with any informal enquiries. Fixed-term: The funds for this post are available for 3 years in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check. To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/17051. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form. Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Closing date for applications is the 30th April 2018, with interviews yet to be confirmed by the department. Please quote reference RD15149 on your application and in any correspondence about this vacancy. The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.[Click Here to Access the Original Job Post]
We are looking for a highly motivated bioinformatics/computational biology post-doctoral associate to join our collaborative research team. We aim to exploit an understanding of normal neuroblast developmental control to restart differentiation in neuroblastoma cells by targeting a key transcriptional network both genetically and with drugs. The successful candidate will work alongside experimental scientists to formulate and test hypotheses that underpin a new approach to therapy for neuroblastoma, providing bioinformatic interpretation of genome-wide datasets generated by research scientists in the Philpott lab, as well as undertake integration with data from patient cohort datasets. Work includes data processing, statistical analysis, integration and visualization of disparate datasets, development of analysis workflows and training, data management and experimental design. The successful candidate will have the opportunity to work under their own initiative and apply their problem solving skills to troubleshoot challenging issues. There is potential for someone who is primarily bioinformatically-focussed to also take part in experimental work if desired and time permitting. Applicants will have a PhD (or equivalent) and sufficient experience of genome-wide analysis techniques to work independently and within a group.
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Additional Info:
Neuroblastoma is a devastating paediatric cancer of the peripheral nervous system that causes 15% of all children's cancer deaths in the UK each year. Neuroblastoma arises from neuroblasts that fail to complete their normal developmental programme but are instead locked in a state of enhanced proliferation and inhibited differentiation. Our group is embedded within the world-class infrastructure on the Cambridge Biomedical Campus, in the the Department of Oncology at the University of Cambridge (https://www.oncology.cam.ac.uk/research/) and will be moving to the newly constructed Wellcome-MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk) in Autumn 2018. We work closely with Dr Jason Carroll in the CRUK Cambridge Institute, Prof. Ben Simons in the Stem Cell Institute and other research groups nationally and internationally to advance research on developing new treatments for neuroblastoma. Please contact Prof. Anna Philpott (ap113@cam.ac.uk) with any informal enquiries. Fixed-term: The funds for this post are available for 3 years in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check. To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/17051. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form. Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Closing date for applications is the 30th April 2018, with interviews yet to be confirmed by the department. Please quote reference RD15149 on your application and in any correspondence about this vacancy. The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.[Click Here to Access the Original Job Post]