Research Associate (Bioinformatics): Regenerative Cardiovascular Medicine

Job ID: 5984
Job date: 2018-04-03
End Date:

Company : University of Cambridge 

Country :

Role : Postdoc  | Research Scientist 


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Job Description:
We are looking to appoint a postdoctoral Research Associate to join the dynamic team of Dr Sanjay Sinha (https://www.cardiovascular.cam.ac.uk/directory/ssinha ). The position is funded through the BHF Centre of Regenerative Medicine (https://www.cardiovascular.cam.ac.uk/research/oxbridgecrm ), one of three national research hubs specialising in cardiovascular regeneration. Membership of the Centre provides a unique opportunity to collaborate with researchers across the partnership (Universities of Bristol, Cambridge, Leeds, Manchester, and Oxford) and with the Imperial and Edinburgh -led Centres. Annual review meetings and cross-Centre events present opportunities for discussion and showcasing of the research.

The focus of this exciting position will be to analyse data obtained from various single-cell multi-omics methods, including transcriptomics, epigenetics marks and chromatin accessibility, applied to the in vitro generated epicardium, human foetal epicardium samples and mouse or zebrafish pre- and post-infarction hearts. The successful applicant will work closely with Dr Nicolas Le Novère at the Babraham Institute (https://lenoverelab.org/ ) with Professor Paul Riley (https://www.dpag.ox.ac.uk/team/paul-riley ) and Professor Ludovic Vallier (https://www.cardiovascular.cam.ac.uk/directory/lvallier ).

Qualifications:

The successful applicant will have a PhD (or equivalent) with a background in bioinformatics and a publication record. Experience with the analysis of NGS data is essential, as are programming skills, in particular in R and Python. It is important that you have written and communication skills are organised and have the ability to work collaboratively with experimental and computational colleagues.


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Additional Info:
The Sinha group research is based on the hypothesis that the human epicardium contributes to heart regeneration after injury. We have pioneered the generation of epicardium from human embryonic and induced pluripotent stem cells (hESC and hiPSC) (Iyer et al., Development 2015;142:1528-41). We are using this in vitro system to understand the molecular regulation of epicardial function, and to produce cells and identify potential new drugs for regenerative medicine.

The Sinha group is a member of the Wellcome Medical Research Council Cambridge Stem Cell Institute, an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments. The Institute currently comprises 29 research groups based across 6 sites in Cambridge and in 2018, all research groups will move to a new building on the Cambridge Biomedical Campus.

Start date:As soon as possible

How to Apply: Apply online at http://hrsystems.admin.cam.ac.uk/recruit-ui/apply/RC15211

Contact:

Dr Sanjay Sinha

ss661@cam.ac.uk

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