Job ID: 149875
Job date: 2017-10-06
End Date:
Company : University of Washington Country : Role : Research Scientist
Job date: 2017-10-06
End Date:
Company : University of Washington Country : Role : Research Scientist
Job Description:
The Department of Biochemistry currently has an outstanding opportunity for a RESEARCH SCIENTIST ENGINEER ASSISTANT. This position is to assist our current team to further improve an established bioinformatic pipeline including high-throughput digital image processing, barcode or base calling to generate DNA sequence information (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178052/), and quantifying DNA co-localization to measure protein interactions. He or she will work with professors and staff engineers to learn and improve established algorithms. Responsibilities of this position include but are not limited to:
Additional Info:
The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty. The Department of Biochemistry at the University of Washington has contributed to many phases of research. Initially recognized for incisive studies of the structure and function of proteins, and the mechanisms of enzyme action, the department branched out into a multitude of other areas. These included: developmental biology of flies, fish, frogs, and mice; molecular mechanisms of aging in yeast and mammals; vertebrate visual and immune responses; chromosome dynamics, cell division, DNA replication and repair; energy transduction during photosynthesis; protein secretion and membrane fusion; translational control and regulated protein degradation; protein structure determination by crystallography and NMR spectroscopy; and protein structure prediction and enzyme design. Our diversity of interests guarantees a rich intellectual and educational environment. The Gu laboratory develops novel technologies to fundamentally improve the engineering of protein therapeutics and tools. In particular, we build protein interaction sequencing technologies by coupling ‘protein barcoding’ techniques to in situ barcode (or polony) sequencing, a powerful extension of next-generation DNA sequencing. In situ polony sequencing can directly measure protein interactions in massively parallel at a single-molecule or single-cell level. An example of protein interaction sequencing is a single-molecular-interaction sequencing (SMI-seq) technology we recently developed (Nature, 2014, 515:554–557) for ‘library-by-library’ or ‘all-by-all’ interaction profiling. We apply SMI-seq and others to measure natural or synthetic protein interactions, to explore the druggability of human protein interactomes, and to develop molecule sensors, vaccines and therapeutic T cells. Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Criminal Conviction History, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed. [Click Here to Access the Original Job Post]
The Department of Biochemistry currently has an outstanding opportunity for a RESEARCH SCIENTIST ENGINEER ASSISTANT. This position is to assist our current team to further improve an established bioinformatic pipeline including high-throughput digital image processing, barcode or base calling to generate DNA sequence information (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178052/), and quantifying DNA co-localization to measure protein interactions. He or she will work with professors and staff engineers to learn and improve established algorithms. Responsibilities of this position include but are not limited to:
- Develop the SMI-seq bioinformatic pipeline.
- Process and present SMI-seq data.
- Assist in the development of SMI-seq technologies.
- Bachelor's or master’s degree, preferred majors: computer science, bioinformatics, or related engineering fields
- Strong programming experience with at least one of the following languages: C++, MATLAB, Python
- Ability to work as a member of a multifunctional development team
Requeriments :
Skills :
- Bioinformatics
- DNA sequencing
- Programing in C++
- Programing in Python
- Programing Skills
- Programming in Matlab
Areas :
Additional Info:
The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty. The Department of Biochemistry at the University of Washington has contributed to many phases of research. Initially recognized for incisive studies of the structure and function of proteins, and the mechanisms of enzyme action, the department branched out into a multitude of other areas. These included: developmental biology of flies, fish, frogs, and mice; molecular mechanisms of aging in yeast and mammals; vertebrate visual and immune responses; chromosome dynamics, cell division, DNA replication and repair; energy transduction during photosynthesis; protein secretion and membrane fusion; translational control and regulated protein degradation; protein structure determination by crystallography and NMR spectroscopy; and protein structure prediction and enzyme design. Our diversity of interests guarantees a rich intellectual and educational environment. The Gu laboratory develops novel technologies to fundamentally improve the engineering of protein therapeutics and tools. In particular, we build protein interaction sequencing technologies by coupling ‘protein barcoding’ techniques to in situ barcode (or polony) sequencing, a powerful extension of next-generation DNA sequencing. In situ polony sequencing can directly measure protein interactions in massively parallel at a single-molecule or single-cell level. An example of protein interaction sequencing is a single-molecular-interaction sequencing (SMI-seq) technology we recently developed (Nature, 2014, 515:554–557) for ‘library-by-library’ or ‘all-by-all’ interaction profiling. We apply SMI-seq and others to measure natural or synthetic protein interactions, to explore the druggability of human protein interactomes, and to develop molecule sensors, vaccines and therapeutic T cells. Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Criminal Conviction History, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed. [Click Here to Access the Original Job Post]