Sr. Principal Scientist Computational Biology, Target and Biomarker Discovery

Job ID: 1617180
Job date: 2017-10-12
End Date:

Company : Pfizer 

Country :

Role : Research Scientist 


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Job Description:
Drive cancer target discovery and patient stratification efforts through analysis of large-scale datasets from functional genomics screens, genomics profiling of clinical and pre-clinical samples using diverse technologies incorporating network and pathway data.

ROLE RESPONSIBILITIES:

  • Apply computational methods to integrate, visualize and interpret data resulting from Proteomic, Genomic, Next Generation Sequencing and efficacy data from pre-clinical and clinical studies.
  • Work closely with teams of biologist and clinicians developing analysis approaches for systematic target and patient population identification, propose new experimental approaches and computational analysis to drive novel target and biomarker discovery. Establish network-based methods for omics-scale data integration and mining, drive the computational data-mining efforts for target discovery and patient selection. Effectively collaborate with Drug Discovery teams of cell biologists, biochemists, pharmacologists and clinicians. Deduce, summarize and communicate results of data mining and analysis and contribute to understanding of drug mechanism of action, target indication, patient selection strategies and identification of translational and response biomarkers.
QUALIFICATIONS

Ph.D. and/or Post Doctorate training in computational biology or bio-informatics with at least 8 years industry or academic experience in a analyzing large-scale molecular data.

Demonstrated expertise in:

-Development and application of network-based methods for integration and analysis of genomics data.

-Data mining and application of systems biology approaches to large OMICS datasets.

-Analysis of the Next Generation Sequencing data including; WES, RNAseq, miRNA, Epigenetics, functional genomics and synthetic lethal screens.

-Solid programming skills in R, Perl Python, SQL etc. in LINUX/UNIX environment.

Strong organizational and interpersonal skills including excellent oral and written communication and ability to work effectively in matrix collaborative teams.


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Additional Info:
EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act:

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Additional Offer Details

Grade: 13

Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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