Job Role: Postdoc
Cellular differentiation refers to acquisition of specific cell-fates during development. It has become evident that this process involves genomewide reprogramming of epigenetic modifications such as histone marks resulting in transcriptional changes that drives cell-fate. Building on our expertise in epigenomics and gene regulation, we aim to investigate function of certain novel chromatin regulators and transcription factors in mediating epigenome and transcriptome reprogramming during lineage commitment and terminal differentiation. [More]
Modified DNA bases play an important epigenetic role in the regulation of gene expression in development and disease. In mammals there are four different cytidine modifications in genomic DNA known to have an epigenetic function, most prominently 5-hydroxymethylcotosine. There are many more known DNA modifications, whose function remain unknown and await characterization, including of the cellular enzymes that affect these modifications, which will be the aim of the project. Our lab has a broad expertise not only in molecular cell biology and bioinformatics, but in bioanalytical chemistry, where we are using LC/MS/MS detection for modified nucleobases. Beyond mass spectrometry analysis, we will knockout candidate genes in mouse embryonic stem cells (mESCs) by the CRISPR/Cas9 genome editing technique and analyze the physiological relevance of these genes in pluripotency and during mESC in vitro differentiation by e.g. RNA sequencing. Given the biological importance of the new DNA modification, the project promises to be ground breaking, opening unexplored fields in epigenetics. This PhD project will be particularly suited for students with interest in biochemistry and/or bioorganic analytical methods, particularly mass spectrometry. [More]
We are looking for a highly motivated PhD with a strong background in bioinformatics/computational biology. The project concerns the mechanisms underlying the functional diversification of human natural killer cells. Studies of immunological diversity in populations are combined with the integration and analysis of high-dimensional single-cell data generated by RNASeq, flow cytometry and CyTOF. The candidate will work at the interface of immunology, cancer and bioinformatics. Immune informatics is a nascent field with many challenging computational tasks ahead. The candidate, together with colleagues, will particularly focus on computational approaches toward clinically relevant immune profiling of immune-cell repertoires in patients. Depending on qualifications of the applicant, the position may offer the possibility to develop an independent line of research within the overall scope of the groups research program. [More]
IRTA: IRTA is seeking a researcher with knowledge in the field of biotechnology and bioinformatics (mainly on the genomics of infectious agents and populations, and genome evolution). He/she must have experience in research project participation and be English Spain [More]
Based on experience and qualifications;it will satisfy the NIH NRSA guidelines. Excellent Benefits.: University of Michigan: The Department of Computational Medicine and Bioinformatics (DCMB, Medical School) and the Department of Environmental Health Sciences (EHS, School... Ann Arbor, Michigan [More]
Commensurate with Experience: Johns Hopkins University, SKCCC: Seeking Computational Biologist/Bioinformatics for epigenetics projects. RO1 funded lab in epigenetics of pancreatic and colorectal cancer. Baltimore, Maryland (US) [More]
Competitive: St. Jude Children's Research Hospital: The Computational Biology (Comp. Bio) Department at St. Jude Children’s Research Hospital (SJCRH) is seeking a highly motivated Bioinformatics Research Scientist to work on familial cancer studies in conjunction with investigators from Division of Cancer Memphis, Tennessee [More]
Competitive: St. Jude Children's Research Hospital: The Bioinformatics Research Scientist participates in method development, data analysis, statistical analysis, experimental and analytical design and data management for an immunology program working on T cell biology (including TCR repertoire), influenz Memphis, Tennessee [More]
Competitive: St. Jude Children's Research Hospital: We are seeking a Bioinformatics Research Scientist to participate in collaborative projects between the Department of Computational Biology and the laboratory of Dr. Mitchell Weiss in the Department of Hematology. The Weiss Lab focuses on mechanisms of n Memphis, Tennessee [More]
Postdoctoral Fellow (PDF) position is now open in my research group at VCU. My lab uses in-silico approaches to generate predictive models and interpret information encoded in proteins and small RNAs, from individual molecules, through complete proteomes and genomes, to studies that span thousands of organisms. We authored several state-of-the-art...more... [More]