Current research areas include data management and analytics for biosciences, development of high-performance computing software for chemistry and material... From Lawrence Berkeley National Laboratory - 01 May 2016 05:59:39 GMT - View all Berkeley jobs [More]

Originally posted on 2016-05-01

Postdoctoral studies (scholarship) in computational transcriptomics and epigenomics in acute myeloid leukemia (AML). Description of project and work. This postdoc project is a collaborative project between Andreas Lennartsson’s research team at the department of Biosciences and Nutrition, Karolinska Institutet and Sören Lehmann’s group at the Institution of Medical Sciences at Uppsala University. Andreas Lennartsson’s research group is interested in the epigenetic regulation of normal myelopoiesis and acute myeloid leukemia (AML) (https://kiedit.ki.se/en/people/andlen). The aim is to identify key epigenetic factors that regulate enhancer activity and multi-potency in hematopoietic stem cells and dissect how they contribute to the development of leukemic stem cells. The group of Sören Lehmann is a translational research group focusing on AML spanning from basic science to clinical trials and both clinicians and basic researchers are active in the group. The focus is on epigenetic dysregulation in AML with an important aim to develop new treatment strategies based on epigenetic dysregulation. The Lehmann and Lennarssons’ groups are working very closely together creating an inspiring work environment containing complementary expertise. The epigenetic machinery is often perturbed in AML and contributes to leukomogenesis via different mechanisms. Increased knowledge about the aberrant epigenetic machinery will help us to better understand the mechanisms that give rise to AML. Our common research will potentially provide tools for novel therapies. This collaborative project offers you a unique possibility to analyze AML patient samples using novel state of the art methodologies. You will bridge the clinical and preclinical research at our institutes. Duties Bioinformatics is central in our research and you will work close together with other postdocs and PhD students in both groups. You will be involved in planning experiments, final analysis and visualization of the results. You will have the possibility to participate national and international collaborations. You will analyze data from multiple technology platforms that are obtained using techniques such as Chromatin Immune Precipitation (ChIP)-sequencing, RNA-seq/CAGE, ATAC-seq and Whole Genome Bisulphite sequencing. This position provides opportunity for growth and development as an independent investigator, as there will be possibilities for initiating new research directions.  [More]

Originally posted on 2016-04-29

The Bioinformatics group of Prof. Dr. Rolf Backofen is looking for a PhD student or Postdoctoral researcher In all model organisms a variety of non-coding RNAs have been found but so far their mode of actions and functions are almost unknown. Interactions between these ncRNAs and their targets often rely on direct RNA-RNA interactions, however, they are usually controlled by additional protein factors. In this project we will investigate the effect of an bacterial RNA helicase on RNA-RNA interactions to gain new insights in fundamental processes like regulation of gene expression, cell differentiation, and cellular stress adaption. The tasks of the candidate will include kinetic modeling of RNAs, design of RNA sense-antisense pairs, model optimization based on wet lab results, prediction of binding positions, and CLIPseq analysis.   The position is for initially 2 years with the possibility of extension. The salary will be determined in accordance with TVL-E13 (100 %).   Further information: http://www.bioinf.uni-freiburg.de/.  [More]

Originally posted on 2016-05-02

Competitive: St. Jude Children's Research Hospital: The bioinformatics research scientist will work on integrative analysis of whole-genome, whole exome and transcriptoming sequencing data with epigenetic data including WGBS, ChIP-seq and RNA-seq to understand the role of epigenetic regulation in childhoo Memphis, Tennessee  [More]

Originally posted on 2016-05-02

International Institute of Molecular and Cell Biology: Two PhD student positions in RNA bioinformatics are available in the Bujnicki group in IIMCB, Warsaw, Poland. We are looking for junior scientists with energy and passion, interested in bioinformatics, software development and biological data analysis, Poland  [More]

Originally posted on 2016-04-26

We are seeking energetic and passionate argonauts of all stages (postdocs, graduate students, undergraduates, and research associates) to join our team. We are passionate about understanding the fundamental challenge of cancer evolution. If you are naturally curious about biology, want to invent new technologies, and enjoy working in a creative and dynamic environment, we would love to work with you! [More]

Originally posted on 2016-05-01

We are seeking a Postdoctoral Scientist in Inflammation to join Professor Alison Simmons’ research group. The goal of this project is to characterise pathogenic lesions in Crohn’s disease at a global molecular level to highlight biological pathways that are over or underactive within human intestinal subsets in Crohn’s. The Postdoctoral Fellowship is being funded and performed in close collaboration with Celgene, and will involve short secondments within Celgene labs to for the postholder to develop skills linked to work in industry. In Oxford the Postdoctoral Scientist will work in collaboration with members of the Target Discovery Institute and Wellcome Trust Centre for Human Genetics, Oxford. [More]

Originally posted on 2016-04-21

We are seeking two Postdoctoral Scientists to join Professor Chris Newbold’s Molecular Parasitology research group to work on the understanding of immunity and pathogenesis in malaria. The role will involve work on the control of expression of these multi-gene families, their function and the immune response to them using extensive sequence data that has been compiled. [More]

Originally posted on 2016-04-21

A postdoc position funded by an ERC Consolidator grant is available in theVan Attikum laboratory at the Leiden University Medical Center (LUMC; Leiden, the Netherlands). As a postdoc you will study how chromatin remodeling enzymes counteract DNA strand breaks and replication stress in order to prevent genomic instability in human cells. The research will encompass a cross-disciplinary approach that combines novel and cutting-edge genomics with bioinformatics, genetics, biochemistry and high-resolution microscopy. [More]

Originally posted on 2016-04-21

The division 'Proteomics of Stem Cells and Cancer' is looking for a postdoc to strengthen its research in the area of cancer proteomics. Our division (headed by Prof. Jeroen Krijgsveld) is funded by the Excellence Cluster CellNetworks and is part both of the DKFZ and the Medical Faculty of Heidelberg University. We are housed in a fully newly equipped laboratory including state-of-the-art mass spectrometry (e.g. Orbitrap QE-HF and Fusion), and we collaborate with many groups on campus, in Heidelberg, and internationally. Our main research interest is to develop proteomic tools that help us to understand how the proteome is dynamically regulated in time and space, and how this underlies properties related to malignancy in cancer and to pluripotency in stem cells. Our current research focuses on the role of secretory proteins, protein interactions in chromatin, and proteins that interact with RNA. The postdoc position is available to work in the area of quantitative cancer proteomics, focusing on protein expression profiling and integration with NGS, or its intersection with chromatin biology and signal transduction, depending on the interest and expertise of the candidate. [More]

Originally posted on 2016-04-21