Post-doctoral position in viral bioinformatics

Job ID:
Job date: 2014-11-21
End Date:

Company : CNRS & Lyon University 

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Role : Postdoc 


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Job Description:

We are welcoming applications from enthusiastic and independent post-doctoral candidates to participate in our ECOFECT LabEx grant-funded project.
We will develop a new bioinformatic approach to identify the sites of the Dengue virus genome that interact with the mosquito cell machinery.

Background
To control the Dengue virus epidemics, the most promising strategies target the mosquito host to stop viral transmission to humans. However, it is very hard to optimise these strategies and predict whether they could be successful because little is known about how the virus interacts with its mosquito host.

Project
We will implement a new approach that combines viral evolution experiments in mosquito cells with deep sequencing runs (collaboration with Marlène Dreux’s team). The postdoctoral project aims at developing bioinformatic and statistical methods to infer a map of interactions between the mosquito cell machinery and the viral genome. Doing so requires addressing two important problems in viral bioinformatics, i/ the assembly of viral haplotypes from short reads and ii/ fitness prediction for assembled haplotypes.

Environment
The host laboratory (LBBE) is a stimulating and pleasant place to work, where one can meet biologists, physicians, computer scientists, mathematicians and statisticians working on problems that range from ecology to medicine, through genomics and evolution. In addition, the post-doctoral researcher will enjoy close interactions with virologists in the team of Marlène Dreux (CIRI, ENSLyon).
Lyon is the second largest city in France, is famous for its food, is a UNESCO World Heritage site and enjoys a very convenient central location in Europe.

Candidates
The applicants are expected to have a strong background in bioinformatics or phylogenetics or population genetics or computer science or statistics. The ideal candidate should be highly motivated, curious and enthusiastic to work in a collaborative team. Proven ability to identify research objectives and meet agreed deadlines, self-motivation and flexibility are essential. Excellent written and oral skills in English are required….


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