Job ID:
Job date: 2018-04-13
End Date:
Company : Recruitomics Consulting Country : Role : Research Scientist
Job date: 2018-04-13
End Date:
Company : Recruitomics Consulting Country : Role : Research Scientist
Job Description:
We are currently seeking a motivated scientist with experience in genomics and bioinformatics for position with our translational research team to contribute to our Next Generation Sequencing (NGS) software pipeline development and strain characterization efforts. The successful candidate will develop and validate software pipelines to automate metagenomic and transcriptomic data analysis and visualization to enable characterization of microbial communities and engineered strain functional profiles. In addition, this role will develop predictive modeling strategies to combine NGS and metabolomics datasets to anticipate strain activity in simulated gastrointestinal tract (GI) and animal models. The ideal candidate should have experience in NGS data processing, multivariate analysis techniques, mathematical modeling, and data visualization, as well as software development and validation. This role represents a unique opportunity to meaningfully advance our understanding of engineered bacterial strain physiology and activity in the host environment. Responsibilities:
Additional Info:
Synlogic is a leading biotechnology/synthetic biology company located in Cambridge, MA that is focused on the development of novel therapeutic microorganisms for the treatment of important human diseases, including inborn errors of metabolism.[Click Here to Access the Original Job Post]
We are currently seeking a motivated scientist with experience in genomics and bioinformatics for position with our translational research team to contribute to our Next Generation Sequencing (NGS) software pipeline development and strain characterization efforts. The successful candidate will develop and validate software pipelines to automate metagenomic and transcriptomic data analysis and visualization to enable characterization of microbial communities and engineered strain functional profiles. In addition, this role will develop predictive modeling strategies to combine NGS and metabolomics datasets to anticipate strain activity in simulated gastrointestinal tract (GI) and animal models. The ideal candidate should have experience in NGS data processing, multivariate analysis techniques, mathematical modeling, and data visualization, as well as software development and validation. This role represents a unique opportunity to meaningfully advance our understanding of engineered bacterial strain physiology and activity in the host environment. Responsibilities:
- Develop and rigorously validate NGS and metabolomics data processing and visualization software pipelines.
- Characterize metagenomic signatures of treatment with therapeutic microorganisms.
- Identify differentially expressed bacterial genes/pathways in simulated GI models.
- Construct and validate predictive models of therapeutic strain activity.
- Prepare Next Generation Sequencing (NGS) libraries, and operate/maintain NGS instruments.
- Implement data storage, documentation, and quality protocols in collaboration with Synlogic’s IT staff.
- Generate data reports, rigorously maintain an electronic laboratory notebook, and accurately present data to project teams.
- MS with 5+ years experience or PhD in Genomics, Bioinformatics, Computer Science, or a relevant field.
- Demonstrated experience with bioinformatics software development and NGS data analysis.
- Deep understanding of statistical methods for interpreting ‘omics datasets.
- Fluency with Linux, Bash, Python, and related statistical and data visualization software packages.
- Experience with cloud computing solutions.
- Experience with transcriptomic, metagenomic, or metabolomic datasets.
- Experience with multivariate analysis techniques.
- Experience with machine learning methods preferred.
- Experience with constructing relational databases preferred.
- Molecular Biology skills for NGS library construction a plus.
- Strong attention to detail and accuracy and an ability to work independently to solve technical problems.
- Highly organized with excellent written and oral communication skills.
- Effective management of time and effort to meet deadlines.
- Ability to work effectively in a highly collaborative, cross-functional environment.
Requeriments :
Skills :
- Bioinformatics
- Cloud Computing
- genomic
- Lunix/Unix
- Machine Learning
- Metagenomics
- Modeling
- molecular biology
- Multivariate Analysis
- Next Generation Sequencing
- Programing in Python
- Software Design
- Statistics
- Transcriptomics
Areas :
Additional Info:
Synlogic is a leading biotechnology/synthetic biology company located in Cambridge, MA that is focused on the development of novel therapeutic microorganisms for the treatment of important human diseases, including inborn errors of metabolism.[Click Here to Access the Original Job Post]