Job ID: 350819
Job date: 2015-11-13
End Date:
Company : Discovery Biology Nurix Country : Role : Research Scientist
Job date: 2015-11-13
End Date:
Company : Discovery Biology Nurix Country : Role : Research Scientist
Job Description:
Additional Info:
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Job Description
Company Nurix, Inc. is a science-focused and goal-oriented organization that is committed to bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of new class of drugs that can restore normal cellular homeostasis. Nurix was founded by internationally-recognized experts in the UPS field and received its initial funding from leading life science investors, Third Rock Ventures and The Column Group. The Company recently entered into a multi-year strategic collaboration with Celgene for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix is based in San Francisco, California Position We are seeking a highly skilled and motivated bioinformatics scientist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The successful candidate will have a broad bioinformatics experience base with a good working knowledge of cancer genomics and pathway biology. This individual will work closely with our drug discovery project scientists and informatics group to build Nurix’s internal bioinformatics capabilities and address project needs. Activities will include mining publicly available NGS data to identify new target opportunities and address translational research questions for drug discovery programs, analyzing omics data sets and analyzing shRNA/CRISPR library screen data sets. The candidate must be self-driven, organized, able to work well with project scientists to solve complex bioinformatics problems and able to thrive in an exciting startup environment.Requirements
• Ph.D. in bioinformatics, computational biology or related field with 10+ years of industry experience in bioinformatics (or 5+ yrs for Scientist II) • Knowledge of cancer genomics and pathway biology • Experience in accessing, curating and analyzing large genomic data sets (e.g., NGS data for cancer mutation, copy number and expression) • Ability to analyze and interpret complex omics datasets (e.g., proteomics, RNAseq, metabolomics data) • Experience in processing deep sequencing data generated during the execution of pooled shRNA/CRISPR screens • Proficiency in appropriate programming languages and software (e.g., Perl/Python/Spotfire) and database management • Successful track record collaborating with cross-functional teams and an ability to communicate and present bioinformatics concepts and interpretations to teams and management • Excellent interpersonal skills and ability to work productively in a highly dynamic environment • Strong scientific curiosity and initiative Fit with Nurix Culture and Values • Strong team orientation, highly collaborative; solutions and results-oriented focus • Hands-on approach; resourceful and open to diverse points of view • Self-driven and enthusiastic with the ability to thrive in a dynamic “start-up” environment Application Process Click Apply Now and include a pdf of your CV and include “Bioinformatics, Discovery Biology” in the subject line. Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the USSkills :
Areas :
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