Job ID:
Job date: 2018-04-25
End Date: 2018-06-24
Company : The Jackson Laboratory Country : United States Role : Student
Job date: 2018-04-25
End Date: 2018-06-24
Company : The Jackson Laboratory Country : United States Role : Student
Job Description:
Exciting opportunity to join our Center for Biometric Analysis team this summer! Our Knockout Mouse Project (KOMP) aims to generate 1000 knockout mouse strains over the next 4 years and characterize them through a broad primary phenotyping screen. The mutant mice and the phenotyping data we produce are openly available to the scientific community (www.mousephenotype.org ). The team is looking to find an enthusiastic and talented Summer Intern to contribute to the quality control of the data generated by KOMP. This summer intern position is designed specifically for individuals enrolled in a 4 year Statistics, Mathematics, Bioinformatics or applicable degree looking to advance their scientific/research training prior to pursuing further educational endeavors. Key Responsibilities:
Additional Info:
About us: The Jackson Laboratory (JAX, www.jax.org) is a nonprofit biomedical research institute with over 2,000 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. A National Cancer Institute-designated Cancer Center, JAX has a mammalian genetics headquarters in Bar Harbor, Maine, a facility in Sacramento, California, and a genomic medicine facility, The Jackson Laboratory for Genomic Medicine (JAX-GM), in Farmington, Connecticut. The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine! Our Values: INTEGRITY - Courage and commitment to do what is right PEOPLE - Inspiring our people to enhance the health of all ONE TEAM - Unified by our promise to transform medicine and science EXCELLENCE - Achieving world-class results INNOVATION - Leading with discovery and creative solutions STEWARDSHIP - Caring for and enhancing the resources entrusted to us What do we have to offer? JAX offers a dynamic and supportive work environment. Our campus offers a fitness center with an award-winning wellness program, an onsite full service cafeteria, and a fully operational primary care facility available to employees and their families. Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health. The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Learn more about career opportunities at JAX: http://www.jax.org/careers.[Click Here to Access the Original Job Post]
Exciting opportunity to join our Center for Biometric Analysis team this summer! Our Knockout Mouse Project (KOMP) aims to generate 1000 knockout mouse strains over the next 4 years and characterize them through a broad primary phenotyping screen. The mutant mice and the phenotyping data we produce are openly available to the scientific community (www.mousephenotype.org ). The team is looking to find an enthusiastic and talented Summer Intern to contribute to the quality control of the data generated by KOMP. This summer intern position is designed specifically for individuals enrolled in a 4 year Statistics, Mathematics, Bioinformatics or applicable degree looking to advance their scientific/research training prior to pursuing further educational endeavors. Key Responsibilities:
- Develop robust reference ranges for each experimental endpoint delineating biologically impossible and improbably values.
- Collaborate with domain experts to validate proposed reference ranges
- Collaborate with Research Assistants to implement the application of these biological reference ranges.
- Collaborate with statistician and project manager to develop statistical methods and visualization tools to identify biological outliers.
- Cumulative baseline review
- Mutant mouse line review
- Perform statistical analysis to find statistically significant, biologically relevant hits
- Systematic review of meta-data to ensure mouse detail information is necessary, sufficient, accurate and current
- Collaborate with statistician and project manager to review and resolve QC issues identified by IMPC Wranglers
- Currently enrolled in Statistics, Mathematics, Bioinformatics, or related major.
- Knowledge about summary statistics, effect size, power analysis.
- Knowledge about statistical hypothesis testing such as Students’ t-test, ANOVA, Linear regression, nonparametric statistics etc. Previous experience with Generalized linear model, Linear mixed model, etc. preferred.
- Fluent in R programming language and built in tools such as ggplot. Experience with R shiny, mark down is preferred.
- The ability to work in a demanding, fast paced, team-oriented environment, while maintaining a high-level of professionalism.
- Ability to develop technical documents and presentations.
- Effectively and productively interact with a range of colleagues including senior Faculty, Project Managers, Biostatisticians and Mouse Phenotypers
Skills :
Areas :
Additional Info:
About us: The Jackson Laboratory (JAX, www.jax.org) is a nonprofit biomedical research institute with over 2,000 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. A National Cancer Institute-designated Cancer Center, JAX has a mammalian genetics headquarters in Bar Harbor, Maine, a facility in Sacramento, California, and a genomic medicine facility, The Jackson Laboratory for Genomic Medicine (JAX-GM), in Farmington, Connecticut. The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine! Our Values: INTEGRITY - Courage and commitment to do what is right PEOPLE - Inspiring our people to enhance the health of all ONE TEAM - Unified by our promise to transform medicine and science EXCELLENCE - Achieving world-class results INNOVATION - Leading with discovery and creative solutions STEWARDSHIP - Caring for and enhancing the resources entrusted to us What do we have to offer? JAX offers a dynamic and supportive work environment. Our campus offers a fitness center with an award-winning wellness program, an onsite full service cafeteria, and a fully operational primary care facility available to employees and their families. Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health. The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Learn more about career opportunities at JAX: http://www.jax.org/careers.[Click Here to Access the Original Job Post]